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Scientific paper - Review paper
Metals in Alzheimer’s Disease
Biomedicines, 11 (2023), 4; 1161. https://doi.org/10.3390/biomedicines11041161
Babić Leko, Mirjana; Langer Horvat, Lea; Španić Popovački, Ena; Zubčić, Klara; Hof, Patrick R.; Šimić, Goran

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Babić Leko, M., Langer Horvat, L., Španić Popovački, E., Zubčić, K., Hof, P. R. & Šimić, G. (2023). Metals in Alzheimer’s Disease. Biomedicines, 11. (4). doi: 10.3390/biomedicines11041161

Babić Leko, Mirjana, et al. "Metals in Alzheimer’s Disease." Biomedicines, vol. 11, no. 4, 2023. https://doi.org/10.3390/biomedicines11041161

Babić Leko, Mirjana, Lea Langer Horvat, Ena Španić Popovački, Klara Zubčić, Patrick R. Hof and Goran Šimić. "Metals in Alzheimer’s Disease." Biomedicines 11, no. 4 (2023). https://doi.org/10.3390/biomedicines11041161

Babić Leko, M., et al. (2023) 'Metals in Alzheimer’s Disease', Biomedicines, 11(4). doi: 10.3390/biomedicines11041161

Babić Leko M, Langer Horvat L, Španić Popovački E, Zubčić K, Hof PR, Šimić G. Metals in Alzheimer’s Disease. Biomedicines [Internet]. 2023 April 12 [cited 2024 April 15];11(4). doi: 10.3390/biomedicines11041161

M. Babić Leko, L. Langer Horvat, E. Španić Popovački, K. Zubčić, P. R. Hof and G. Šimić, "Metals in Alzheimer’s Disease", Biomedicines, vol. 11, no. 4, April 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:365205. [Accessed: 15 April 2024]

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Metadata
Title (english)Metals in Alzheimer’s Disease
AuthorMirjana Babić Leko
AuthorLea Langer Horvat
AuthorEna Španić Popovački
AuthorKlara Zubčić
AuthorPatrick R. Hof
AuthorGoran Šimić
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Abstract (english)
The role of metals in the pathogenesis of Alzheimer’s disease (AD) is still debated. Although previous research has linked changes in essential metal homeostasis and exposure to environmental heavy metals to the pathogenesis of AD, more research is needed to determine the relationship between metals and AD. In this review, we included human studies that (1) compared the metal concentrations between AD patients and healthy controls, (2) correlated concentrations of AD cerebrospinal fluid (CSF) biomarkers with metal concentrations, and (3) used Mendelian randomization (MR) to assess the potential metal contributions to AD risk. Although many studies have examined various metals in dementia patients, understanding the dynamics of metals in these patients remains difficult due to considerable inconsistencies among the results of individual studies. The most consistent findings were for Zn and Cu, with most studies observing a decrease in Zn levels and an increase in Cu levels in AD patients. However, several studies found no such relation. Because few studies have compared metal levels with biomarker levels in the CSF of AD patients, more research of this type is required. Given that MR is revolutionizing epidemiologic research, additional MR studies that include participants from diverse ethnic backgrounds to assess the causal relationship between metals and AD risk are critical.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomedicines
Numberingvol. 11, no. 4, 1161
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines11041161
URN:NBNurn:nbn:hr:105:365205
Publication2023-04-12
Document URLhttps://www.mdpi.com/2227-9059/11/4/1161
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-10-20 07:31:18