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Metals in Alzheimer’s Disease
Biomedicines, 11 (2023), 4; 1161. https://doi.org/10.3390/biomedicines11041161
Babić Leko, Mirjana; Langer Horvat, Lea; Španić Popovački, Ena; Zubčić, Klara; Hof, Patrick R.; Šimić, Goran

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Babić Leko, M., Langer Horvat, L., Španić Popovački, E., Zubčić, K., Hof, P. R. i Šimić, G. (2023). Metals in Alzheimer’s Disease. Biomedicines, 11. (4). doi: 10.3390/biomedicines11041161

Babić Leko, Mirjana, et al. "Metals in Alzheimer’s Disease." Biomedicines, vol. 11, br. 4, 2023. https://doi.org/10.3390/biomedicines11041161

Babić Leko, Mirjana, Lea Langer Horvat, Ena Španić Popovački, Klara Zubčić, Patrick R. Hof i Goran Šimić. "Metals in Alzheimer’s Disease." Biomedicines 11, br. 4 (2023). https://doi.org/10.3390/biomedicines11041161

Babić Leko, M., et al. (2023) 'Metals in Alzheimer’s Disease', Biomedicines, 11(4). doi: 10.3390/biomedicines11041161

Babić Leko M, Langer Horvat L, Španić Popovački E, Zubčić K, Hof PR, Šimić G. Metals in Alzheimer’s Disease. Biomedicines [Internet]. 12.04.2023. [pristupljeno 29.11.2024.];11(4). doi: 10.3390/biomedicines11041161

M. Babić Leko, L. Langer Horvat, E. Španić Popovački, K. Zubčić, P. R. Hof i G. Šimić, "Metals in Alzheimer’s Disease", Biomedicines, vol. 11, br. 4, Travanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:365205. [Citirano: 29.11.2024.]

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Podaci o radu
Naslov (engleski)Metals in Alzheimer’s Disease
AutorMirjana Babić Leko
AutorLea Langer Horvat
AutorEna Španić Popovački
AutorKlara Zubčić
AutorPatrick R. Hof
AutorGoran Šimić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Sažetak (engleski)
The role of metals in the pathogenesis of Alzheimer’s disease (AD) is still debated. Although previous research has linked changes in essential metal homeostasis and exposure to environmental heavy metals to the pathogenesis of AD, more research is needed to determine the relationship between metals and AD. In this review, we included human studies that (1) compared the metal concentrations between AD patients and healthy controls, (2) correlated concentrations of AD cerebrospinal fluid (CSF) biomarkers with metal concentrations, and (3) used Mendelian randomization (MR) to assess the potential metal contributions to AD risk. Although many studies have examined various metals in dementia patients, understanding the dynamics of metals in these patients remains difficult due to considerable inconsistencies among the results of individual studies. The most consistent findings were for Zn and Cu, with most studies observing a decrease in Zn levels and an increase in Cu levels in AD patients. However, several studies found no such relation. Because few studies have compared metal levels with biomarker levels in the CSF of AD patients, more research of this type is required. Given that MR is revolutionizing epidemiologic research, additional MR studies that include participants from diverse ethnic backgrounds to assess the causal relationship between metals and AD risk are critical.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedicines
Brojčani podacivol. 11, br. 4, 1161
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines11041161
URN:NBNurn:nbn:hr:105:365205
Datum objave publikacije2023-04-12
URL dokumentahttps://www.mdpi.com/2227-9059/11/4/1161
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-10-20 07:31:18