Plućne eozinofilije

master's thesis

• Title (english): Pulmonary eosinophilia
• Author: Leon Biljan
• Mentor: Marija Gomerčić Palčić (mentor)
• Committee member: Sanja Popović-Grle (predsjednik povjerenstva)
• Committee member: Marko Jakopović (član povjerenstva)
• Committee member: Marija Gomerčić Palčić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2023-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Plućne eozinofilije su raznolika skupina bolesti karakterizirane s infiltracijom eozinofila u sve dijelove pluća. Razne infekcije, lijekovi, maligniteti, autoimuni i idiopatski procesi mogu biti uzrok nastanka ove bolesti no u svijetu je najčešći infestacija parazitima poput askarioze i strongiloidoze. Plućne eozinofilije, ovisno o tome znamo li uzrok ili ne, dijele se na primarne ili idiopatske i sekundarne ili ekstrinzične. Akutna eozinofilna pneumonija, kronična eozinofilna pneumonija, hipereozinofilni sindrom i eozinofilna granulomatoza s poliangiitisom spadaju u primarne plućne eozinofilije, a alergijska bronhopulmonalna aspergiloza te plućne eozinofilije koje se javljaju kao posljedica infestacija parazitima, zračenja, unosa lijekova ili malignih oboljenja spadaju u sekundarne plućne eozinofilije. Iako klinička slika nije identična u svih tipova plućnih eozinofilija, najčešći simptomi su kašalj, zaduha, piskanje i jedna razina respiratorne insuficijencije te sistemski simptomi poput povišene tjelesne temperature, gubitka apetita i/ili gubitka na tjelesnoj teţini i malaksalosti. Dijagnoza se postavlja se temelju kliničke slike, detaljne anamneze i dijagnostike koja uključuje laboratorijsku analizu krvi, radiološke pretrage pluća kao RTG i HRCT te bronhoskopiju s ili bez biopsije pluća, analizu BAL-a te testova plućne funkcije. Većina pacijenata s plućnim eozinofilijama liječe se sistemskim kortikosteroidima te antihelminticima i antifungalnim lijekovima ukoliko su uzročnici paraziti odnosno gljive.

Abstract (english)

Pulmonary eosinophilia is a heterogeneous group of diseases characterized by infiltration of eosinophils in all parts of the lungs. Various infections, drugs, malignancies, autoimmune and idiopathic processes can be the cause, but the most common in the world is parasite infestation such as ascariasis and strongyloidosis. Pulmonary eosinophilia, depending on whether we know the cause or not, can be divided into primary or idiopathic and secondary or extrinsic. Acute eosinophilic pneumonia, chronic eosinophilic pneumonia, hypereosinophilic syndrome and Churg-Strauss syndrome belong to primary pulmonary eosinophilia, while allergic bronchopulmonary aspergillosis and pulmonary eosinophilia that occur as a result of parasite infestation, radiation, drug intake or malignant diseases belong to secondary pulmonary eosinophilia. Although the clinical picture is not identical in all types of pulmonary eosinophilia, the most common symptoms are cough, shortness of breath, wheezing and a level of respiratory failure and systemic symptoms such as fever, loss of appetite and/or weight loss and malaise. The diagnosis is based on the picture, detailed history and diagnostics that include blood tests, radiographic imaging of the lungs such as X-ray along with HRCT and bronchoscopy with or without lung biopsy, BAL analysis and pulmonary function tests. Most patients with pulmonary eosinophilia are treated with systemic corticosteroids as well as antihelmintics and antifungal drugs if the causative agents are parasites or fungi.

• Keywords: plućne eozinofilije; zaduha; kašalj; CT; kortikosteroidi
• Keywords (english): pulmonary eosinophilia; shortness of breath; cough; CT; cocticosteroids
• Language: croatian
• URN:NBN: urn:nbn:hr:105:489087
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-10-23 09:49:44