PET/CT u dijagnostici karcinoma prostate

master's thesis

• Title (english): PET/CT in prostate cancer diagnosis
• Author: Bruno Mioč
• Mentor: Dražen Huić (mentor)
• Committee member: Sanja Kusačić Kuna (predsjednik povjerenstva)
• Committee member: Gordana Ivanac (član povjerenstva)
• Committee member: Dražen Huić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Nuclear Medicine); Zagreb
• Defense date and country: 2023-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Nuclear Medicine

Abstract

Pozitronska emisijska tomografija/kompjutorizirana tomografija (PET/CT) je nuklearno medicinska funkcionalna slikovna tehnika s dokazanom kliničkom vrijednošću, prvenstveno u onkologiji.

Kod karcinoma prostate, kao drugog najčešćeg karcinoma (nakon tumora pluća) i petog vodećeg uzroka smrti kod muškaraca u svijetu, PET/CT se pokazao kao obećavajući modalitet određivanja i primarnog i rekurentnog karcinoma prostate.

U PET/CT-u karcinoma prostate koristi se nekoliko radiofarmaka (radiofarmaceutski pripravci radionuklida) koju su pokazali visoku osjetljivost i specifičnost u detekciji karcinoma. Među njima najčešće korišteni radiofarmaci poput C-11-kolina, F-18-kolina, F-18-NaF-a (F-18 natrij fluorid) i Ga-68-PSMA (Ga-68-prostata specifični membranski antigen) istaknuli su se kao najučinkovitiji u otkrivanju primarnog karcinoma prostate, koštanih metastaza i udaljenih metastaza karcinoma prostate.

U usporedbi s ostalim slikovnim metodama, PET/CT se istaknuo kao bolja metoda snimanja karcinoma prostate, ponajviše zbog svoje raspoloživosti, efikasnosti kao i zbog ekonomske povoljnosti.

Abstract (english)

Positron emission tomography/computed tomography (PET/CT) is a nuclear medicine functional imaging technique with proven clinical value, primarily in oncology.

In prostate cancer, as the second most common cancer (after lung cancer) and the fifth leading cause of death in men worldwide, PET/CT has been shown to be a promising modality for the determination of both primary and recurrent prostate cancer.

In PET/CT of prostate cancer, several radiopharmaceuticals (radiopharmaceutical preparations of radionuclides) are used, which have shown high sensitivity and specificity in cancer detection. Among them, the most commonly used radiopharmaceuticals such as 11C-choline, F-18-choline, F-18-NaF (Sodium fluoride F-18) and Ga-68-PSMA (gallium-68 prostate specific membrane antigen) stood out as the most effective in detecting primary prostate cancer, bone metastases and distant metastases of prostate cancer.

Compared to other imaging methods, PET/CT stood out as a better method of imaging prostate cancer, mostly due to its availability, efficiency, and economic benefits.

• Keywords: pozitronska emisijska tomografija/kompjutorizirana tomografija (PET/CT); karcinom prostate; radiofarmaci; F-18-kolin; Ga-68-PSMA
• Keywords (english): positron emission tomography/computed tomography (PET/CT); prostate cancer; radiopharmaceuticals; F-18-choline; Ga-68-PSMA
• Language: croatian
• URN:NBN: urn:nbn:hr:105:682573
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-10-26 12:34:22