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Scientific paper - Review paper
Hantavirus Pulmonary Syndrome Caused by Puumala Orthohantavirus - A Case Report and Literature Review
Microorganisms, 11 (2023), 12; 2963. https://doi.org/10.3390/microorganisms11122963
Santini, Marija; Ljubić, Jelena; Šoštar, Nikola; Vilibić-Čavlek, Tatjana; Bogdanić, Maja; Zakotnik, Samo; Avšič-Županc, Tatjana; Korva, Miša; Kurolt, Ivan Christian; Radmanić, Leona; Šimičić, Petra; Krznarić, Juraj; Gjurašin, Branimir; Kutleša, Marko; Višković, Klaudija; Balent, Nataša Cetinić; Žunec, Renata; Margeta Marić, Ivana; Ribarović, Ana; Židovec-Lepej, Snježana More authors...

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Santini, M., Ljubić, J., Šoštar, N., Vilibić Čavlek, T., Bogdanić, M., Zakotnik, S. ... Židovec Lepej, S. (2023). Hantavirus Pulmonary Syndrome Caused by Puumala Orthohantavirus - A Case Report and Literature Review. Microorganisms, 11. (12). doi: 10.3390/microorganisms11122963

Santini, Marija, et al. "Hantavirus Pulmonary Syndrome Caused by Puumala Orthohantavirus - A Case Report and Literature Review." Microorganisms, vol. 11, no. 12, 2023. https://doi.org/10.3390/microorganisms11122963

Santini, Marija, Jelena Ljubić, Nikola Šoštar, Tatjana Vilibić Čavlek, Maja Bogdanić, Samo Zakotnik, Tatjana Avšič Županc, et al. "Hantavirus Pulmonary Syndrome Caused by Puumala Orthohantavirus - A Case Report and Literature Review." Microorganisms 11, no. 12 (2023). https://doi.org/10.3390/microorganisms11122963

Santini, M., et al. (2023) 'Hantavirus Pulmonary Syndrome Caused by Puumala Orthohantavirus - A Case Report and Literature Review', Microorganisms, 11(12). doi: 10.3390/microorganisms11122963

Santini M, Ljubić J, Šoštar N, Vilibić Čavlek T, Bogdanić M, Zakotnik S, and sur.. Hantavirus Pulmonary Syndrome Caused by Puumala Orthohantavirus - A Case Report and Literature Review. Microorganisms [Internet]. 2023 December 12 [cited 2024 December 21];11(12). doi: 10.3390/microorganisms11122963

M. Santini, et al., "Hantavirus Pulmonary Syndrome Caused by Puumala Orthohantavirus - A Case Report and Literature Review", Microorganisms, vol. 11, no. 12, December 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:449087. [Accessed: 21 December 2024]

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Metadata
Title (english)Hantavirus Pulmonary Syndrome Caused by Puumala Orthohantavirus - A Case Report and Literature Review
AuthorMarija Santini
AuthorJelena Ljubić
AuthorNikola Šoštar
AuthorTatjana Vilibić-Čavlek
AuthorMaja Bogdanić
AuthorSamo Zakotnik
AuthorTatjana Avšič-Županc
AuthorMiša Korva
AuthorIvan Christian Kurolt
AuthorLeona Radmanić
AuthorPetra Šimičić
AuthorJuraj Krznarić
AuthorBranimir Gjurašin
AuthorMarko Kutleša
AuthorKlaudija Višković
AuthorNataša Cetinić Balent
AuthorRenata Žunec
AuthorIvana Margeta Marić
AuthorAna Ribarović
AuthorSnježana Židovec-Lepej
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Infectious Diseases)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Abstract (english)
In this article, we report on a rare case of acute respiratory distress syndrome (ARDS) caused by the Puumala orthohantavirus (PUUV), which is typically associated with hemorrhagic fever with renal syndrome (HFRS). This is the first documented case of PUUV-associated ARDS in Southeast Europe. The diagnosis was confirmed by serum RT-PCR and serology and corroborated by phylogenetic analysis and chemokine profiling. The patient was a 23-year-old male from Zagreb, Croatia, who had recently traveled throughout Europe. He presented with fever, headache, abdominal pain, and sudden onset of ARDS. Treatment involved high-flow nasal cannula oxygen therapy and glucocorticoids, which resulted in a full recovery. A systematic literature review identified 10 cases of hantavirus pulmonary syndrome (HPS) caused by PUUV in various European countries and Turkey between 2002 and 2023. The median age of patients was 53 years (range 24–73), and six of the patients were male. Most patients were treated in intensive care units, but none received antiviral therapy targeting PUUV. Eight patients survived hospitalization. The presented case highlights the importance of considering HPS in the differential diagnosis of ARDS, even in areas where HFRS is the dominant form of hantavirus infection.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMicroorganisms
Numberingvol. 11, no. 12, 2963
e-ISSN2076-2607
DOIhttps://doi.org/10.3390/microorganisms11122963
URN:NBNurn:nbn:hr:105:449087
Publication2023-12-12
Document URLhttps://www.mdpi.com/2076-2607/11/12/2963
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-03-04 08:41:42