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Scientific paper - Original scientific paper
Adiponectin level and gene variability are obesity and metabolic syndrome markers in a young population
Archives of Medical Research, 43 (2012), 2; 145-153. https://doi.org/10.1016/j.arcmed.2012.02.004
Karmelić, Ivana; Lovrić, Jasna; Božina, Tamara; Ljubić, Hana; Vogrinc, Željka; Božina, Nada; Sertić, Jadranka

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Karmelić, I., Lovrić, J., Božina, T., Ljubić, H., Vogrinc, Ž., Božina, N. & Sertić, J. (2012). Adiponectin level and gene variability are obesity and metabolic syndrome markers in a young population. Archives of Medical Research, 43. (2), 145-153. doi: 10.1016/j.arcmed.2012.02.004

Karmelić, Ivana, et al. "Adiponectin level and gene variability are obesity and metabolic syndrome markers in a young population." Archives of Medical Research, vol. 43, no. 2, 2012, pp. 145-153. https://doi.org/10.1016/j.arcmed.2012.02.004

Karmelić, Ivana, Jasna Lovrić, Tamara Božina, Hana Ljubić, Željka Vogrinc, Nada Božina and Jadranka Sertić. "Adiponectin level and gene variability are obesity and metabolic syndrome markers in a young population." Archives of Medical Research 43, no. 2 (2012): 145-153. https://doi.org/10.1016/j.arcmed.2012.02.004

Karmelić, I., et al. (2012) 'Adiponectin level and gene variability are obesity and metabolic syndrome markers in a young population', Archives of Medical Research, 43(2), pp. 145-153. doi: 10.1016/j.arcmed.2012.02.004

Karmelić I, Lovrić J, Božina T, Ljubić H, Vogrinc Ž, Božina N, and sur.. Adiponectin level and gene variability are obesity and metabolic syndrome markers in a young population. Archives of Medical Research [Internet]. 2012 February [cited 2024 November 13];43(2):145-153. doi: 10.1016/j.arcmed.2012.02.004

I. Karmelić, et al., "Adiponectin level and gene variability are obesity and metabolic syndrome markers in a young population", Archives of Medical Research, vol. 43, no. 2, pp. 145-153, February 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:942360. [Accessed: 13 November 2024]

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Metadata
Title (english)Adiponectin level and gene variability are obesity and metabolic syndrome markers in a young population
AuthorIvana Karmelić
AuthorJasna Lovrić
AuthorTamara Božina
AuthorHana Ljubić
AuthorŽeljka Vogrinc
AuthorNada Božina
AuthorJadranka Sertić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND AND AIMS: Human obesity is accepted as an important risk factor for development of MetS. Adiponectin is linked to central obesity and ADIPOQ variants are promising markers for understanding the genetic base of obesity-related disorders. We performed analyses of adiponectin concentrations and ADIPOQ variants and tested their associations with obesity and MetS in young subjects of Croatian origin. ----- METHODS: Biochemical and anthropometric parameters of MetS were obtained for 149 unrelated subjects. Adiponectin levels were measured by ELISA assay. ADIPOQ -11391G>A and -11377C>G were genotyped by real-time PCR. ----- RESULTS: BMI and WC, TG and GLUC showed inverse correlation, whereas HDL-C showed a positive correlation with adiponectin concentrations. For central obesity, we found association with -11377C>G and with -11391G>A polymorphisms. ADIPOQ -11377GG and -11391GA significantly increased the risk for the development of central obesity (OR 5.57 and OR 3.37, respectively). Significant association was found between -11391A, -11377G allele and haplotype and increased TG. -11377C>G and -11391G>A variant were significantly associated with the incidence of MetS. C>G mutation at position -11377 significantly increased the risk of MetS development (OR = 2.93). Compared with the -11391G homozygotes, carriers of the A allele had a significantly increased risk for the development of MetS (OR = 3.15). The test of overall association showed a statistically significant correlation of MetS with -11377C>G and -11391G>A haplotypes (p = 0.008). ----- CONCLUSIONS: Analysis of adiponectin concentration and ADIPOQ -11391G>A and -11377C>G gene variants may be clinically meaningful for estimation of MetS risk in a young population.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleArchives of Medical Research
Numberingvol. 43, no. 2, pp. 145-153
p-ISSN0188-4409
DOIhttps://doi.org/10.1016/j.arcmed.2012.02.004
URN:NBNurn:nbn:hr:105:942360
Publication2012-02
Document URLhttps://doi.org/10.1016/j.arcmed.2012.02.004
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:30:26