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Adiponectin level and gene variability are obesity and metabolic syndrome markers in a young population
Archives of Medical Research, 43 (2012), 2; 145-153. https://doi.org/10.1016/j.arcmed.2012.02.004
Karmelić, Ivana; Lovrić, Jasna; Božina, Tamara; Ljubić, Hana; Vogrinc, Željka; Božina, Nada; Sertić, Jadranka

Citirajte ovaj rad

Karmelić, I., Lovrić, J., Božina, T., Ljubić, H., Vogrinc, Ž., Božina, N. i Sertić, J. (2012). Adiponectin level and gene variability are obesity and metabolic syndrome markers in a young population. Archives of Medical Research, 43. (2), 145-153. doi: 10.1016/j.arcmed.2012.02.004

Karmelić, Ivana, et al. "Adiponectin level and gene variability are obesity and metabolic syndrome markers in a young population." Archives of Medical Research, vol. 43, br. 2, 2012, str. 145-153. https://doi.org/10.1016/j.arcmed.2012.02.004

Karmelić, Ivana, Jasna Lovrić, Tamara Božina, Hana Ljubić, Željka Vogrinc, Nada Božina i Jadranka Sertić. "Adiponectin level and gene variability are obesity and metabolic syndrome markers in a young population." Archives of Medical Research 43, br. 2 (2012): 145-153. https://doi.org/10.1016/j.arcmed.2012.02.004

Karmelić, I., et al. (2012) 'Adiponectin level and gene variability are obesity and metabolic syndrome markers in a young population', Archives of Medical Research, 43(2), str. 145-153. doi: 10.1016/j.arcmed.2012.02.004

Karmelić I, Lovrić J, Božina T, Ljubić H, Vogrinc Ž, Božina N, i sur.. Adiponectin level and gene variability are obesity and metabolic syndrome markers in a young population. Archives of Medical Research [Internet]. 02.2012. [pristupljeno 09.11.2024.];43(2):145-153. doi: 10.1016/j.arcmed.2012.02.004

I. Karmelić, et al., "Adiponectin level and gene variability are obesity and metabolic syndrome markers in a young population", Archives of Medical Research, vol. 43, br. 2, str. 145-153, Veljača 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:942360. [Citirano: 09.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:942360
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Naslov (engleski)Adiponectin level and gene variability are obesity and metabolic syndrome markers in a young population
AutorIvana Karmelić
AutorJasna Lovrić
AutorTamara Božina
AutorHana Ljubić
AutorŽeljka Vogrinc
AutorNada Božina
AutorJadranka Sertić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND AND AIMS: Human obesity is accepted as an important risk factor for development of MetS. Adiponectin is linked to central obesity and ADIPOQ variants are promising markers for understanding the genetic base of obesity-related disorders. We performed analyses of adiponectin concentrations and ADIPOQ variants and tested their associations with obesity and MetS in young subjects of Croatian origin. ----- METHODS: Biochemical and anthropometric parameters of MetS were obtained for 149 unrelated subjects. Adiponectin levels were measured by ELISA assay. ADIPOQ -11391G>A and -11377C>G were genotyped by real-time PCR. ----- RESULTS: BMI and WC, TG and GLUC showed inverse correlation, whereas HDL-C showed a positive correlation with adiponectin concentrations. For central obesity, we found association with -11377C>G and with -11391G>A polymorphisms. ADIPOQ -11377GG and -11391GA significantly increased the risk for the development of central obesity (OR 5.57 and OR 3.37, respectively). Significant association was found between -11391A, -11377G allele and haplotype and increased TG. -11377C>G and -11391G>A variant were significantly associated with the incidence of MetS. C>G mutation at position -11377 significantly increased the risk of MetS development (OR = 2.93). Compared with the -11391G homozygotes, carriers of the A allele had a significantly increased risk for the development of MetS (OR = 3.15). The test of overall association showed a statistically significant correlation of MetS with -11377C>G and -11391G>A haplotypes (p = 0.008). ----- CONCLUSIONS: Analysis of adiponectin concentration and ADIPOQ -11391G>A and -11377C>G gene variants may be clinically meaningful for estimation of MetS risk in a young population.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaArchives of Medical Research
Brojčani podacivol. 43, br. 2, str. 145-153
p-ISSN0188-4409
DOIhttps://doi.org/10.1016/j.arcmed.2012.02.004
URN:NBNurn:nbn:hr:105:942360
Datum objave publikacije2012-02
URL dokumentahttps://doi.org/10.1016/j.arcmed.2012.02.004
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-27 19:30:26