Neuroendocrine tumors of larynx - two case reports and literature review

Scientific paper - Case study

• Title (croatian): Neuroendokrini tumori larinksa - prikaz slučaja i pregled literature
• Author: Tomislav Carić
• Author: Mario Bilić
• Author: Lana Kovač Bilić
• Author: Drago Prgomet
• Author: Jelena Kovačić
• Author: Iva Topić Grahovac
• Author: Zdenka Hutinec
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

Neuroendocrine tumors (NET) of the larynx are rare and heterogenous group, with much confusion about nature and classification of these neoplasms in the past. Diagnosis is based primarily on light microscopy and confirmed by immunohistochemistry and electron microscopy. A classification in 4 different types; paraganglioma, typical carcinoid, atypical carcinoid and small cell neuroendocrine carcinoma (SCNC) is a current consensus. Thorough diagnostic and a proper classification of neuroendocrine neoplasms are of paramount importance--prognosis and treatment differ significantly. We present two cases: 63-year old patient with SCNC of the larynx and a 53-year old patient with atypical carcinoid of the larynx. OctreoScan is useful tools for diagnostics and follow up of the patients and it is predictive for effectiveness of octreotide therapy.

Abstract (croatian)

Neuroendokrini tumori larinksa rijetka su i heterogena grupa neoplazmi o čijoj prirodi i podjeli je u prošlosti bilo
dosta proturječja. Dijagnoza bolesti postavlja se primarno svjetlosnom mikroskopijom, a potvrđuje imunohistokemijom
i elektronskom mikroskopijom. Suvremeni konsenzus je podjela neuroendokrinih tumora na 4 tipa: paragangliom, tipični karcinoid, atipični karcinoid i karcinom malih stanica. Precizna dijagnostika i klasifikacija neuroendokrinih tumora
od najveće je važnosti – prognoza i način liječenja uvelike se razlikuju. Predstavljamo dva slučaja: 63-godišnjeg bolesnika
sa karcinomom malih stanica i 53-godišnjeg bolesnika sa atipičnim karcinoidom larinksa. Oktreosken je važan za
dijagnostiku i praćenje bolesnika te prediktivan za efikasnost terapije oktreotidom.

• Keywords (english): Humans; Laryngeal Neoplasms / diagnosis; Laryngeal Neoplasms / drug therapy; Laryngeal Neoplasms / pathology; Male; Middle Aged; Neuroendocrine Tumors / diagnosis; Neuroendocrine Tumors / drug therapy; Neuroendocrine Tumors / pathology; Octreotide / therapeutic use
• Language: english
• Publication type: Scientific paper - Case study
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Collegium Antropologicum
• Numbering: vol. 36, no. S. 2, pp. 173-178
• p-ISSN: 0350-6134
• URN:NBN: urn:nbn:hr:105:889140
• Publication: 2012-11
• Document URL: https://hrcak.srce.hr/96498
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-27 19:46:54