prikaz prve stranice dokumenta BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality
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Scientific paper - Original scientific paper
BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality
PLoS ONE, 8 (2013), 9; e74083. https://doi.org/10.1371/journal.pone.0074083
Folli, Franco; Boon, Mariëtte R.; van den Berg, Sjoerd A. A.; Wang, Yanan; van den Bossche, Jan; Karkampouna, Sofia; Bauwens, Matthias; De Saint-Hubert, Marijke; van der Horst, Geertje; Vukičević, Slobodan; de Winther, Menno P. J.; Havekes, Louis M.; Jukema, J. Wouter; Tamsma, Jouke T.; van der Pluijm, Gabri; van Dijk, Ko Willems; Rensen, Patrick C. N. More authors...

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Folli, F., Boon, M. R., van den Berg, S. A. A., Wang, Y., van den Bossche, J., Karkampouna, S. ... Rensen, P. C. N. (2013). BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality. PLoS ONE, 8. (9). doi: 10.1371/journal.pone.0074083

Folli, Franco, et al. "BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality." PLoS ONE, vol. 8, no. 9, 2013. https://doi.org/10.1371/journal.pone.0074083

Folli, Franco, Mariëtte R. Boon, Sjoerd A. A. van den Berg, Yanan Wang, Jan van den Bossche, Sofia Karkampouna, Matthias Bauwens, et al. "BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality." PLoS ONE 8, no. 9 (2013). https://doi.org/10.1371/journal.pone.0074083

Folli, F., et al. (2013) 'BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality', PLoS ONE, 8(9). doi: 10.1371/journal.pone.0074083

Folli F, Boon MR, van den Berg SAA, Wang Y, van den Bossche J, Karkampouna S, and sur.. BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality. PLoS ONE [Internet]. 2013 September 16 [cited 2024 December 20];8(9). doi: 10.1371/journal.pone.0074083

F. Folli, et al., "BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality", PLoS ONE, vol. 8, no. 9, September 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:822074. [Accessed: 20 December 2024]

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Metadata
Title (english)BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality
AuthorFranco Folli
AuthorMariëtte R. Boon
AuthorSjoerd A. A. van den Berg
AuthorYanan Wang
AuthorJan van den Bossche
AuthorSofia Karkampouna
AuthorMatthias Bauwens
AuthorMarijke De Saint-Hubert
AuthorGeertje van der Horst
AuthorSlobodan Vukičević
AuthorMenno P. J. de Winther
AuthorLouis M. Havekes
AuthorJ. Wouter Jukema
AuthorJouke T. Tamsma
AuthorGabri van der Pluijm
AuthorKo Willems van Dijk
AuthorPatrick C. N. Rensen
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
BACKGROUND/AIMS: Brown adipose tissue (BAT) dissipates energy stored in triglycerides as heat via the uncoupling protein UCP-1 and is a promising target to combat hyperlipidemia and obesity. BAT is densely innervated by the sympathetic nervous system, which increases BAT differentiation and activity upon cold exposure. Recently, Bone Morphogenetic Protein 7 (BMP7) was identified as an inducer of BAT differentiation. We aimed to elucidate the role of sympathetic activation in the effect of BMP7 on BAT by treating mice with BMP7 at varying ambient temperature, and assessed the therapeutic potential of BMP7 in combating obesity. ----- METHODS AND RESULTS: High-fat diet fed lean C57Bl6/J mice were treated with BMP7 via subcutaneous osmotic minipumps for 4 weeks at 21 °C or 28 °C, the latter being a thermoneutral temperature in which sympathetic activation of BAT is largely diminished. At 21 °C, BMP7 increased BAT weight, increased the expression of Ucp1, Cd36 and hormone-sensitive lipase in BAT, and increased total energy expenditure. BMP7 treatment markedly increased food intake without affecting physical activity. Despite that, BMP7 diminished white adipose tissue (WAT) mass, accompanied by increased expression of genes related to intracellular lipolysis in WAT. All these effects were blunted at 28 °C. Additionally, BMP7 resulted in extensive 'browning' of WAT, as evidenced by increased expression of BAT markers and the appearance of whole clusters of brown adipocytes via immunohistochemistry, independent of environmental temperature. Treatment of diet-induced obese C57Bl6/J mice with BMP7 led to an improved metabolic phenotype, consisting of a decreased fat mass and liver lipids as well as attenuated dyslipidemia and hyperglycemia. ----- CONCLUSION: Together, these data show that BMP7-mediated recruitment and activation of BAT only occurs at subthermoneutral temperature, and is thus likely dependent on sympathetic activation of BAT, and that BMP7 may be a promising tool to combat obesity and associated disorders.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePLoS ONE
Numberingvol. 8, no. 9, e74083
p-ISSN1932-6203
DOIhttps://doi.org/10.1371/journal.pone.0074083
URN:NBNurn:nbn:hr:105:822074
Publication2013-09-16
Document URLhttps://doi.org/10.1371/journal.pone.0074083
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:58:48