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BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality
PLoS ONE, 8 (2013), 9; e74083. https://doi.org/10.1371/journal.pone.0074083
Folli, Franco; Boon, Mariëtte R.; van den Berg, Sjoerd A. A.; Wang, Yanan; van den Bossche, Jan; Karkampouna, Sofia; Bauwens, Matthias; De Saint-Hubert, Marijke; van der Horst, Geertje; Vukičević, Slobodan; de Winther, Menno P. J.; Havekes, Louis M.; Jukema, J. Wouter; Tamsma, Jouke T.; van der Pluijm, Gabri; van Dijk, Ko Willems; Rensen, Patrick C. N. Više autora...

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Folli, F., Boon, M. R., van den Berg, S. A. A., Wang, Y., van den Bossche, J., Karkampouna, S. ... Rensen, P. C. N. (2013). BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality. PLoS ONE, 8. (9). doi: 10.1371/journal.pone.0074083

Folli, Franco, et al. "BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality." PLoS ONE, vol. 8, br. 9, 2013. https://doi.org/10.1371/journal.pone.0074083

Folli, Franco, Mariëtte R. Boon, Sjoerd A. A. van den Berg, Yanan Wang, Jan van den Bossche, Sofia Karkampouna, Matthias Bauwens, et al. "BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality." PLoS ONE 8, br. 9 (2013). https://doi.org/10.1371/journal.pone.0074083

Folli, F., et al. (2013) 'BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality', PLoS ONE, 8(9). doi: 10.1371/journal.pone.0074083

Folli F, Boon MR, van den Berg SAA, Wang Y, van den Bossche J, Karkampouna S, i sur.. BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality. PLoS ONE [Internet]. 16.09.2013. [pristupljeno 19.12.2024.];8(9). doi: 10.1371/journal.pone.0074083

F. Folli, et al., "BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality", PLoS ONE, vol. 8, br. 9, Rujan 2013. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:822074. [Citirano: 19.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:822074
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Naslov (engleski)BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality
AutorFranco Folli
AutorMariëtte R. Boon
AutorSjoerd A. A. van den Berg
AutorYanan Wang
AutorJan van den Bossche
AutorSofia Karkampouna
AutorMatthias Bauwens
AutorMarijke De Saint-Hubert
AutorGeertje van der Horst
AutorSlobodan Vukičević
AutorMenno P. J. de Winther
AutorLouis M. Havekes
AutorJ. Wouter Jukema
AutorJouke T. Tamsma
AutorGabri van der Pluijm
AutorKo Willems van Dijk
AutorPatrick C. N. Rensen
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
BACKGROUND/AIMS: Brown adipose tissue (BAT) dissipates energy stored in triglycerides as heat via the uncoupling protein UCP-1 and is a promising target to combat hyperlipidemia and obesity. BAT is densely innervated by the sympathetic nervous system, which increases BAT differentiation and activity upon cold exposure. Recently, Bone Morphogenetic Protein 7 (BMP7) was identified as an inducer of BAT differentiation. We aimed to elucidate the role of sympathetic activation in the effect of BMP7 on BAT by treating mice with BMP7 at varying ambient temperature, and assessed the therapeutic potential of BMP7 in combating obesity. ----- METHODS AND RESULTS: High-fat diet fed lean C57Bl6/J mice were treated with BMP7 via subcutaneous osmotic minipumps for 4 weeks at 21 °C or 28 °C, the latter being a thermoneutral temperature in which sympathetic activation of BAT is largely diminished. At 21 °C, BMP7 increased BAT weight, increased the expression of Ucp1, Cd36 and hormone-sensitive lipase in BAT, and increased total energy expenditure. BMP7 treatment markedly increased food intake without affecting physical activity. Despite that, BMP7 diminished white adipose tissue (WAT) mass, accompanied by increased expression of genes related to intracellular lipolysis in WAT. All these effects were blunted at 28 °C. Additionally, BMP7 resulted in extensive 'browning' of WAT, as evidenced by increased expression of BAT markers and the appearance of whole clusters of brown adipocytes via immunohistochemistry, independent of environmental temperature. Treatment of diet-induced obese C57Bl6/J mice with BMP7 led to an improved metabolic phenotype, consisting of a decreased fat mass and liver lipids as well as attenuated dyslipidemia and hyperglycemia. ----- CONCLUSION: Together, these data show that BMP7-mediated recruitment and activation of BAT only occurs at subthermoneutral temperature, and is thus likely dependent on sympathetic activation of BAT, and that BMP7 may be a promising tool to combat obesity and associated disorders.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLoS ONE
Brojčani podacivol. 8, br. 9, e74083
p-ISSN1932-6203
DOIhttps://doi.org/10.1371/journal.pone.0074083
URN:NBNurn:nbn:hr:105:822074
Datum objave publikacije2013-09-16
URL dokumentahttps://doi.org/10.1371/journal.pone.0074083
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-27 19:58:48