prikaz prve stranice dokumenta SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population
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Scientific paper - Original scientific paper
SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population
PLoS ONE, 8 (2013), 9; e74042. https://doi.org/doi: 10.1371/journal.pone.0074042
Kirac, Iva; Matošević, Petar; Augustin, Goran; Šimunović, Iva; Hostić, Vedran; Župančić, Sven; Hayward, Caroline; Antoljak, Nataša; Rudan, Igor; Campbell, Harry; Dunlop, Malcolm G.; Vrdoljak, Danko Velimir; Kovačević, Dujo; Zgaga, Lina

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Kirac, I., Matošević, P., Augustin, G., Šimunović, I., Hostić, V., Župančić, S. ... Zgaga, L. (2013). SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population. PLoS ONE, 8. (9). doi: doi: 10.1371/journal.pone.0074042

Kirac, Iva, et al. "SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population." PLoS ONE, vol. 8, no. 9, 2013. https://doi.org/doi: 10.1371/journal.pone.0074042

Kirac, Iva, Petar Matošević, Goran Augustin, Iva Šimunović, Vedran Hostić, Sven Župančić, Caroline Hayward, et al. "SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population." PLoS ONE 8, no. 9 (2013). https://doi.org/doi: 10.1371/journal.pone.0074042

Kirac, I., et al. (2013) 'SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population', PLoS ONE, 8(9). doi: doi: 10.1371/journal.pone.0074042

Kirac I, Matošević P, Augustin G, Šimunović I, Hostić V, Župančić S, and sur.. SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population. PLoS ONE [Internet]. 2013 September 16 [cited 2024 April 16];8(9). doi: doi: 10.1371/journal.pone.0074042

I. Kirac, et al., "SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population", PLoS ONE, vol. 8, no. 9, September 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:317497. [Accessed: 16 April 2024]

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Metadata
Title (english)SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population
AuthorIva Kirac
AuthorPetar Matošević
AuthorGoran Augustin
AuthorIva Šimunović
AuthorVedran Hostić
AuthorSven Župančić
AuthorCaroline Hayward
AuthorNataša Antoljak
AuthorIgor Rudan
AuthorHarry Campbell
AuthorMalcolm G. Dunlop
AuthorDanko Velimir Vrdoljak
AuthorDujo Kovačević
AuthorLina Zgaga
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND: Twenty common genetic variants have been associated with risk of developing colorectal cancer (CRC) in genome wide association studies to date. Since large differences between populations exist, generalisability of findings to any specific population needs to be confirmed. ----- AIM: The aim of this study was to perform an association study between risk variants: rs10795668, rs16892766, rs3802842 and rs4939827 and CRC risk in Croatian population. ----- METHODS: An association study was performed on 320 colorectal cancer cases and 594 controls recruited in Croatia. We genotyped four variants previously associated with CRC: rs10795668, rs16892766, rs3802842 and rs4939827. ----- RESULTS: SMAD7 variant rs4939827 (18q21.1) was significantly associated with CRC risk in Croatian population. C allele was associated with a decreased risk, odds ratio (OR): 0.70 (95% CI: 0.57-0.85, P=3.5E-04). Compared to TT homozygotes, risk was reduced by 34% in heterozygotes (OR=0.66, 95% CI: 0.47-0.92) and by 52% in CC homozygotes (OR=0.48, 95% CI: 0.33-0.72). ----- CONCLUSION: Our results show association of rs4939827 with colorectal cancer risk in Croatian population. The higher strength of the association in comparison to other studies suggests population-specific environmental or genetic factors may be modifying the association. More studies are needed to further describe role of rs4939827 in CRC. Likely reason for failure of replication for other 3 loci is inadequate study power.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePLoS ONE
Numberingvol. 8, no. 9, e74042
p-ISSN1932-6203
DOIhttps://doi.org/doi: 10.1371/journal.pone.0074042
URN:NBNurn:nbn:hr:105:317497
Publication2013-09-16
Document URLhttps://doi.org/10.1371/journal.pone.0074042
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 20:00:41