prikaz prve stranice dokumenta SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population
  Preuzmi
PDF 146.11 KB
Znanstveni rad - Izvorni znanstveni rad
SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population
PLoS ONE, 8 (2013), 9; e74042. https://doi.org/doi: 10.1371/journal.pone.0074042
Kirac, Iva; Matošević, Petar; Augustin, Goran; Šimunović, Iva; Hostić, Vedran; Župančić, Sven; Hayward, Caroline; Antoljak, Nataša; Rudan, Igor; Campbell, Harry; Dunlop, Malcolm G.; Vrdoljak, Danko Velimir; Kovačević, Dujo; Zgaga, Lina

Citirajte ovaj rad

Kirac, I., Matošević, P., Augustin, G., Šimunović, I., Hostić, V., Župančić, S. ... Zgaga, L. (2013). SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population. PLoS ONE, 8. (9). doi: doi: 10.1371/journal.pone.0074042

Kirac, Iva, et al. "SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population." PLoS ONE, vol. 8, br. 9, 2013. https://doi.org/doi: 10.1371/journal.pone.0074042

Kirac, Iva, Petar Matošević, Goran Augustin, Iva Šimunović, Vedran Hostić, Sven Župančić, Caroline Hayward, et al. "SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population." PLoS ONE 8, br. 9 (2013). https://doi.org/doi: 10.1371/journal.pone.0074042

Kirac, I., et al. (2013) 'SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population', PLoS ONE, 8(9). doi: doi: 10.1371/journal.pone.0074042

Kirac I, Matošević P, Augustin G, Šimunović I, Hostić V, Župančić S, i sur.. SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population. PLoS ONE [Internet]. 16.09.2013. [pristupljeno 10.05.2024.];8(9). doi: doi: 10.1371/journal.pone.0074042

I. Kirac, et al., "SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population", PLoS ONE, vol. 8, br. 9, Rujan 2013. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:317497. [Citirano: 10.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:317497
Prijavite se u repozitorij kako biste mogli spremiti objekt u svoju listu.
Podaci o radu
Naslov (engleski)SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population
AutorIva Kirac
AutorPetar Matošević
AutorGoran Augustin
AutorIva Šimunović
AutorVedran Hostić
AutorSven Župančić
AutorCaroline Hayward
AutorNataša Antoljak
AutorIgor Rudan
AutorHarry Campbell
AutorMalcolm G. Dunlop
AutorDanko Velimir Vrdoljak
AutorDujo Kovačević
AutorLina Zgaga
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND: Twenty common genetic variants have been associated with risk of developing colorectal cancer (CRC) in genome wide association studies to date. Since large differences between populations exist, generalisability of findings to any specific population needs to be confirmed. ----- AIM: The aim of this study was to perform an association study between risk variants: rs10795668, rs16892766, rs3802842 and rs4939827 and CRC risk in Croatian population. ----- METHODS: An association study was performed on 320 colorectal cancer cases and 594 controls recruited in Croatia. We genotyped four variants previously associated with CRC: rs10795668, rs16892766, rs3802842 and rs4939827. ----- RESULTS: SMAD7 variant rs4939827 (18q21.1) was significantly associated with CRC risk in Croatian population. C allele was associated with a decreased risk, odds ratio (OR): 0.70 (95% CI: 0.57-0.85, P=3.5E-04). Compared to TT homozygotes, risk was reduced by 34% in heterozygotes (OR=0.66, 95% CI: 0.47-0.92) and by 52% in CC homozygotes (OR=0.48, 95% CI: 0.33-0.72). ----- CONCLUSION: Our results show association of rs4939827 with colorectal cancer risk in Croatian population. The higher strength of the association in comparison to other studies suggests population-specific environmental or genetic factors may be modifying the association. More studies are needed to further describe role of rs4939827 in CRC. Likely reason for failure of replication for other 3 loci is inadequate study power.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLoS ONE
Brojčani podacivol. 8, br. 9, e74042
p-ISSN1932-6203
DOIhttps://doi.org/doi: 10.1371/journal.pone.0074042
URN:NBNurn:nbn:hr:105:317497
Datum objave publikacije2013-09-16
URL dokumentahttps://doi.org/10.1371/journal.pone.0074042
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-27 20:00:41