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Scientific paper - Review paper
Huntingtonova bolest
Liječnički vjesnik, 134 (2012), 11-12; 346-350. urn:nbn:hr:105:702455
Pogledić, Ivana; Relja, Maja

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Pogledić, I. & Relja, M. (2012). Huntingtonova bolest . Liječnički vjesnik, 134. (11-12), 346-350. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:702455

Pogledić, Ivana and Maja Relja. "Huntingtonova bolest ." Liječnički vjesnik, vol. 134, no. 11-12, 2012, pp. 346-350. https://urn.nsk.hr/urn:nbn:hr:105:702455

Pogledić, Ivana and Maja Relja. "Huntingtonova bolest ." Liječnički vjesnik 134, no. 11-12 (2012): 346-350. https://urn.nsk.hr/urn:nbn:hr:105:702455

Pogledić, I. and Relja, M. (2012) 'Huntingtonova bolest ', Liječnički vjesnik, 134(11-12), pp. 346-350. Available at: https://urn.nsk.hr/urn:nbn:hr:105:702455 (Accessed 14 November 2024)

Pogledić I, Relja M. Huntingtonova bolest . Liječnički vjesnik [Internet]. 2012 November [cited 2024 November 14];134(11-12):346-350. Available at: https://urn.nsk.hr/urn:nbn:hr:105:702455

I. Pogledić and M. Relja, "Huntingtonova bolest ", Liječnički vjesnik, vol. 134, no. 11-12, pp. 346-350, November 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:702455. [Accessed: 14 November 2024]

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Metadata
Title (croatian)Huntingtonova bolest
Title (english)Huntington's disease
AuthorIvana Pogledić
AuthorMaja Relja
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Huntington's disease and/or chorea (HD) is autosomal dominant neurodegenerative disease that never skips generations. The first description was provided by George Huntington in the year 1872. Its prevalence in the world is 8-10 per 100000 inhabitants and in Croatia 4.46 per 100 000 inhabitants. It starts between 30 and 50 years of age and ends after 15-20 years with death. It is a disease of CAG triplet repeats and is characterized by poliglutamine repeats. The number of CAG trinucleotid repeats correlates with the age of the onset of the first symptoms, as well as with the clinical picture. The selective therapy for Huntington's chorea still does not exists and for symptomatic treatment the blockers of dopamine have turned out to be the most useful.
Abstract (croatian)
Huntingtonova bolest i/ili koreja (HD) autosomno je dominantna neurodegenerativna bolest koja nikada ne preskače generacije. Prvi ju je opisao George Huntington 1872. godine. Prevalencija u svijetu je 8–10 na 100 000 stanovnika, dok je u nas objavljeno 4,46 na 100 000 stanovnika. Započinje uglavnom između 30. i 50. godine života i završava smrtno za 15–20 godina. Bolest je to ponavljanja tripleta CAG, a karakterizira ju ekspanzija poliglutaminskog slijeda. Broj trinukleotidnih CAG-ponavljanja negativno korelira s dobi javljanja prvih simptoma, kao i s težinom kliničke slike. Za sada ne postoji selektivna terapija Huntingtonove koreje, a kao simptomatsko liječenje najdjelotvorniji su blokatori dopamina.
Keywords (english)
Languagecroatian
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleLiječnički vjesnik
Numberingvol. 134, no. 11-12, pp. 346-350
p-ISSN0024-3477
URN:NBNurn:nbn:hr:105:702455
Publication2012-11
Document URLhttp://lijecnicki-vjesnik.hlz.hr/lijecnicki-vjesnik/huntingtonova-bolest/
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 20:04:51