prikaz prve stranice dokumenta Systemically available bone morphogenetic protein two and seven affect bone metabolism
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Scientific paper - Original scientific paper
Systemically available bone morphogenetic protein two and seven affect bone metabolism
International Orthopaedics, 38 (2014), 9; 1979-1985. https://doi.org/10.1007/s00264-014-2425-8
Dumić-Čule, Ivo; Brkljačić, Jelena; Rogić, Dunja; Bordukalo Nikšić, Tatjana; Tikvica Luetić, Ana; Drača, Nataša; Kufner, Vera; Trkulja, Vladimir; Grgurević, Lovorka; Vukičević, Slobodan

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Dumić Čule, I., Brkljačić, J., Rogić, D., Bordukalo Nikšić, T., Tikvica Luetić, A., Drača, N. ... Vukičević, S. (2014). Systemically available bone morphogenetic protein two and seven affect bone metabolism. International Orthopaedics, 38. (9), 1979-1985. doi: 10.1007/s00264-014-2425-8

Dumić Čule, Ivo, et al. "Systemically available bone morphogenetic protein two and seven affect bone metabolism." International Orthopaedics, vol. 38, no. 9, 2014, pp. 1979-1985. https://doi.org/10.1007/s00264-014-2425-8

Dumić Čule, Ivo, Jelena Brkljačić, Dunja Rogić, Tatjana Bordukalo Nikšić, Ana Tikvica Luetić, Nataša Drača, Vera Kufner, Vladimir Trkulja, Lovorka Grgurević and Slobodan Vukičević. "Systemically available bone morphogenetic protein two and seven affect bone metabolism." International Orthopaedics 38, no. 9 (2014): 1979-1985. https://doi.org/10.1007/s00264-014-2425-8

Dumić Čule, I., et al. (2014) 'Systemically available bone morphogenetic protein two and seven affect bone metabolism', International Orthopaedics, 38(9), pp. 1979-1985. doi: 10.1007/s00264-014-2425-8

Dumić Čule I, Brkljačić J, Rogić D, Bordukalo Nikšić T, Tikvica Luetić A, Drača N, and sur.. Systemically available bone morphogenetic protein two and seven affect bone metabolism. International Orthopaedics [Internet]. 2014 September [cited 2024 December 20];38(9):1979-1985. doi: 10.1007/s00264-014-2425-8

I. Dumić Čule, et al., "Systemically available bone morphogenetic protein two and seven affect bone metabolism", International Orthopaedics, vol. 38, no. 9, pp. 1979-1985, September 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:665606. [Accessed: 20 December 2024]

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Metadata
Title (english)Systemically available bone morphogenetic protein two and seven affect bone metabolism
AuthorIvo Dumić-Čule
AuthorJelena Brkljačić
AuthorDunja Rogić
AuthorTatjana Bordukalo Nikšić
AuthorAna Tikvica Luetić
AuthorNataša Drača
AuthorVera Kufner
AuthorVladimir Trkulja
AuthorLovorka Grgurević
AuthorSlobodan Vukičević
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
PURPOSE: Bone morphogenetic protein (BMP)-2 and -7 are used in patients with long-bone fractures, nonunions and spinal fusions. It is unknown whether their potential systemic bioavailability following local bone administration might affect skeletal metabolism. To answer this question, we examined effects of systemically administered BMP-2 and -7 on bone in a newly developed rat model with a low level of calciotropic hormones. ----- METHODS: Removal of thyroid and parathyroid glands (TPTx) in rats resulted in a decreased level of calciotropic hormones and subsequent bone loss assessed by micro computed tomography (micro-CT) and measurement of serum bone formation and resorption markers, including osteocalcin, C-telopeptide, osteoprotegerin and receptor activator of nuclear factor kappa-B ligand. Results were complemented with in vitro studies on osteoblast and osteoclast activity by both BMP-2 and -7. The doses used were calculated from published pharmacodynamic studies and bioavailability results from preclinical BMP-2 and -7 studies. ----- RESULTS: TPTx resulted in bone loss, which was restored by systemic administration of 10-70 μg/kg of BMP-2 and 10-250 μg/kg of BMP-7. BMP-2 showed a higher capacity for enhancing trabecular microarchitecture, whereas BMP-7 augmented trabecular thickness. In vitro experiments revealed that BMP-2 and -7 when uncoupled increased the number and activity of both osteoblasts and osteoclasts. ----- CONCLUSIONS: Surprisingly, both BMP-2 and -7 showed an increased bone volume in an in vivo environment of low calciotropic hormones. Locally administered BMP-2 and -7 from bone devices might become partially available in circulation but will not mediate systemic bone loss.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleInternational Orthopaedics
Numberingvol. 38, no. 9, pp. 1979-1985
p-ISSN0341-2695
DOIhttps://doi.org/10.1007/s00264-014-2425-8
URN:NBNurn:nbn:hr:105:665606
Publication2014-09
Document URLhttps://doi.org/10.1007/s00264-014-2425-8
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:11:01