prikaz prve stranice dokumenta Systemically available bone morphogenetic protein two and seven affect bone metabolism
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Systemically available bone morphogenetic protein two and seven affect bone metabolism
International Orthopaedics, 38 (2014), 9; 1979-1985. https://doi.org/10.1007/s00264-014-2425-8
Dumić-Čule, Ivo; Brkljačić, Jelena; Rogić, Dunja; Bordukalo Nikšić, Tatjana; Tikvica Luetić, Ana; Drača, Nataša; Kufner, Vera; Trkulja, Vladimir; Grgurević, Lovorka; Vukičević, Slobodan

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Dumić Čule, I., Brkljačić, J., Rogić, D., Bordukalo Nikšić, T., Tikvica Luetić, A., Drača, N. ... Vukičević, S. (2014). Systemically available bone morphogenetic protein two and seven affect bone metabolism. International Orthopaedics, 38. (9), 1979-1985. doi: 10.1007/s00264-014-2425-8

Dumić Čule, Ivo, et al. "Systemically available bone morphogenetic protein two and seven affect bone metabolism." International Orthopaedics, vol. 38, br. 9, 2014, str. 1979-1985. https://doi.org/10.1007/s00264-014-2425-8

Dumić Čule, Ivo, Jelena Brkljačić, Dunja Rogić, Tatjana Bordukalo Nikšić, Ana Tikvica Luetić, Nataša Drača, Vera Kufner, Vladimir Trkulja, Lovorka Grgurević i Slobodan Vukičević. "Systemically available bone morphogenetic protein two and seven affect bone metabolism." International Orthopaedics 38, br. 9 (2014): 1979-1985. https://doi.org/10.1007/s00264-014-2425-8

Dumić Čule, I., et al. (2014) 'Systemically available bone morphogenetic protein two and seven affect bone metabolism', International Orthopaedics, 38(9), str. 1979-1985. doi: 10.1007/s00264-014-2425-8

Dumić Čule I, Brkljačić J, Rogić D, Bordukalo Nikšić T, Tikvica Luetić A, Drača N, i sur.. Systemically available bone morphogenetic protein two and seven affect bone metabolism. International Orthopaedics [Internet]. 09.2014. [pristupljeno 19.12.2024.];38(9):1979-1985. doi: 10.1007/s00264-014-2425-8

I. Dumić Čule, et al., "Systemically available bone morphogenetic protein two and seven affect bone metabolism", International Orthopaedics, vol. 38, br. 9, str. 1979-1985, Rujan 2014. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:665606. [Citirano: 19.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:665606
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Podaci o radu
Naslov (engleski)Systemically available bone morphogenetic protein two and seven affect bone metabolism
AutorIvo Dumić-Čule
AutorJelena Brkljačić
AutorDunja Rogić
AutorTatjana Bordukalo Nikšić
AutorAna Tikvica Luetić
AutorNataša Drača
AutorVera Kufner
AutorVladimir Trkulja
AutorLovorka Grgurević
AutorSlobodan Vukičević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
PURPOSE: Bone morphogenetic protein (BMP)-2 and -7 are used in patients with long-bone fractures, nonunions and spinal fusions. It is unknown whether their potential systemic bioavailability following local bone administration might affect skeletal metabolism. To answer this question, we examined effects of systemically administered BMP-2 and -7 on bone in a newly developed rat model with a low level of calciotropic hormones. ----- METHODS: Removal of thyroid and parathyroid glands (TPTx) in rats resulted in a decreased level of calciotropic hormones and subsequent bone loss assessed by micro computed tomography (micro-CT) and measurement of serum bone formation and resorption markers, including osteocalcin, C-telopeptide, osteoprotegerin and receptor activator of nuclear factor kappa-B ligand. Results were complemented with in vitro studies on osteoblast and osteoclast activity by both BMP-2 and -7. The doses used were calculated from published pharmacodynamic studies and bioavailability results from preclinical BMP-2 and -7 studies. ----- RESULTS: TPTx resulted in bone loss, which was restored by systemic administration of 10-70 μg/kg of BMP-2 and 10-250 μg/kg of BMP-7. BMP-2 showed a higher capacity for enhancing trabecular microarchitecture, whereas BMP-7 augmented trabecular thickness. In vitro experiments revealed that BMP-2 and -7 when uncoupled increased the number and activity of both osteoblasts and osteoclasts. ----- CONCLUSIONS: Surprisingly, both BMP-2 and -7 showed an increased bone volume in an in vivo environment of low calciotropic hormones. Locally administered BMP-2 and -7 from bone devices might become partially available in circulation but will not mediate systemic bone loss.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaInternational Orthopaedics
Brojčani podacivol. 38, br. 9, str. 1979-1985
p-ISSN0341-2695
DOIhttps://doi.org/10.1007/s00264-014-2425-8
URN:NBNurn:nbn:hr:105:665606
Datum objave publikacije2014-09
URL dokumentahttps://doi.org/10.1007/s00264-014-2425-8
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 08:11:01