prikaz prve stranice dokumenta Krüppel-like transcription factor 8 (Klf8) is expressed and active in the neurons of the mouse brain
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Scientific paper - Original scientific paper
Krüppel-like transcription factor 8 (Klf8) is expressed and active in the neurons of the mouse brain
Gene, 570 (2015), 1; 132-140. https://doi.org/10.1016/j.gene.2015.06.016
Dobrivojević, Marina; Habek, Nikola; Kapuralin, Katarina; Ćurlin, Marija; Gajović, Srećko

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Dobrivojević, M., Habek, N., Kapuralin, K., Ćurlin, M. & Gajović, S. (2015). Krüppel-like transcription factor 8 (Klf8) is expressed and active in the neurons of the mouse brain. Gene, 570. (1), 132-140. doi: 10.1016/j.gene.2015.06.016

Dobrivojević, Marina, et al. "Krüppel-like transcription factor 8 (Klf8) is expressed and active in the neurons of the mouse brain." Gene, vol. 570, no. 1, 2015, pp. 132-140. https://doi.org/10.1016/j.gene.2015.06.016

Dobrivojević, Marina, Nikola Habek, Katarina Kapuralin, Marija Ćurlin and Srećko Gajović. "Krüppel-like transcription factor 8 (Klf8) is expressed and active in the neurons of the mouse brain." Gene 570, no. 1 (2015): 132-140. https://doi.org/10.1016/j.gene.2015.06.016

Dobrivojević, M., et al. (2015) 'Krüppel-like transcription factor 8 (Klf8) is expressed and active in the neurons of the mouse brain', Gene, 570(1), pp. 132-140. doi: 10.1016/j.gene.2015.06.016

Dobrivojević M, Habek N, Kapuralin K, Ćurlin M, Gajović S. Krüppel-like transcription factor 8 (Klf8) is expressed and active in the neurons of the mouse brain. Gene [Internet]. 2015 October 01 [cited 2024 April 11];570(1):132-140. doi: 10.1016/j.gene.2015.06.016

M. Dobrivojević, N. Habek, K. Kapuralin, M. Ćurlin and S. Gajović, "Krüppel-like transcription factor 8 (Klf8) is expressed and active in the neurons of the mouse brain", Gene, vol. 570, no. 1, pp. 132-140, October 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:139926. [Accessed: 11 April 2024]

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Metadata
Title (english)Krüppel-like transcription factor 8 (Klf8) is expressed and active in the neurons of the mouse brain
AuthorMarina Dobrivojević
AuthorNikola Habek
AuthorKatarina Kapuralin
AuthorMarija Ćurlin
AuthorSrećko Gajović
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Krüppel-like transcription factor 8 (KLF8) is a transcription factor suggested to be involved in various cellular events, including malignant cell transformation, still its expression in the adult rodent brain remained unknown. To analyze Klf8 in the mouse brain and to identify cell types expressing it, a specific transgenic Klf8(Gt1Gaj) mouse was used. The resulting Klf8 gene-driven β-galactosidase activity was visualized by X-gal histochemical staining of the brain sections. The obtained results were complemented by in situ RNA hybridization and immunohistochemistry. Klf8 was highly expressed throughout the adult mouse brain gray matter including the cerebral cortex, hippocampus, olfactory bulb, hypothalamus, pallidum, and striatum, but not in the cerebellum. Immunofluorescent double-labeling revealed that KLF8-immunoreactive cells were neurons, and the staining was located in their nucleus. This was the first study showing that Klf8 was highly expressed in various regions of the mouse brain and in particular in the neurons, where it was localized in the cell nuclei.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleGene
Numberingvol. 570, no. 1, pp. 132-140
p-ISSN0378-1119
DOIhttps://doi.org/10.1016/j.gene.2015.06.016
URN:NBNurn:nbn:hr:105:139926
Publication2015-10-01
Document URLhttps://doi.org/10.1016/j.gene.2015.06.016
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:11:11