prikaz prve stranice dokumenta Non-linear actions of physiological agents: Finite disarrangements elicit fitness benefits
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Scientific paper - Review paper
Non-linear actions of physiological agents: Finite disarrangements elicit fitness benefits
Redox Biology, 13 (2017); 235-243. https://doi.org/10.1016/j.redox.2017.05.008
Sedlić, Filip; Kovač, Zdenko

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Sedlić, F. & Kovač, Z. (2017). Non-linear actions of physiological agents: Finite disarrangements elicit fitness benefits. Redox Biology, 13., 235-243. doi: 10.1016/j.redox.2017.05.008

Sedlić, Filip and Zdenko Kovač. "Non-linear actions of physiological agents: Finite disarrangements elicit fitness benefits." Redox Biology, vol. 13, 2017, pp. 235-243. https://doi.org/10.1016/j.redox.2017.05.008

Sedlić, Filip and Zdenko Kovač. "Non-linear actions of physiological agents: Finite disarrangements elicit fitness benefits." Redox Biology 13 (2017): 235-243. https://doi.org/10.1016/j.redox.2017.05.008

Sedlić, F. and Kovač, Z. (2017) 'Non-linear actions of physiological agents: Finite disarrangements elicit fitness benefits', Redox Biology, 13, pp. 235-243. doi: 10.1016/j.redox.2017.05.008

Sedlić F, Kovač Z. Non-linear actions of physiological agents: Finite disarrangements elicit fitness benefits. Redox Biology [Internet]. 2017 October [cited 2024 November 09];13:235-243. doi: 10.1016/j.redox.2017.05.008

F. Sedlić and Z. Kovač, "Non-linear actions of physiological agents: Finite disarrangements elicit fitness benefits", Redox Biology, vol. 13, pp. 235-243, October 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:802636. [Accessed: 09 November 2024]

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Metadata
Title (english)Non-linear actions of physiological agents: Finite disarrangements elicit fitness benefits
AuthorFilip Sedlić
AuthorZdenko Kovač
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Finite disarrangements of important (vital) physiological agents and nutrients can induce plethora of beneficial effects, exceeding mere attenuation of the specific stress. Such response to disrupted homeostasis appears to be universally conserved among species. The underlying mechanism of improved fitness and longevity, when physiological agents act outside their normal range is similar to hormesis, a phenomenon whereby toxins elicit beneficial effects at low doses. Due to similarity with such non-linear response to toxins described with J-shaped curve, we have coined a new term "mirror J-shaped curves" for non-linear response to finite disarrangement of physiological agents. Examples from the clinical trials and basic research are provided, along with the unifying mechanisms that tie classical non-linear response to toxins with the non-linear response to physiological agents (glucose, oxygen, osmolarity, thermal energy, calcium, body mass, calorie intake and exercise). Reactive oxygen species and cytosolic calcium seem to be common triggers of signaling pathways that result in these beneficial effects. Awareness of such phenomena and exploring underlying mechanisms can help physicians in their everyday practice. It can also benefit researchers when designing studies and interpreting growing number of scientific data showing non-linear responses to physiological agents.
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleRedox Biology
Numberingvol. 13, pp. 235-243
p-ISSN2213-2317
DOIhttps://doi.org/10.1016/j.redox.2017.05.008
URN:NBNurn:nbn:hr:105:802636
Publication2017-10
Document URLhttps://doi.org/10.1016/j.redox.2017.05.008
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:12:22