prikaz prve stranice dokumenta Aristolochic acid and the etiology of endemic (Balkan) nephropathy
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Scientific paper - Original scientific paper
Aristolochic acid and the etiology of endemic (Balkan) nephropathy
Proceedings of the National Academy of Sciences, 104 (2007), 29; 12129-12134. https://doi.org/10.1073/pnas.0701248104
Grollman, Arthur P.; Shibutani, Shinya; Moriya, Masaaki; Miller, Fredrick; Wu, Lin; Moll, Ute; Suzuki, Naomi; Fernandes, Andrea; Rosenquist, Thomas; Medverec, Zvonimir; Jakovina, Krunoslav; Brdar, Branko; Slade, Neda; Turesky, Robert J.; Goodenough, Angela K.; Rieger, Robert; Vukelić, Mato; Jelaković, Bojan More authors...

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Grollman, A. P., Shibutani, S., Moriya, M., Miller, F., Wu, L., Moll, U. ... Jelaković, B. (2007). Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Proceedings of the National Academy of Sciences, 104. (29), 12129-12134. doi: 10.1073/pnas.0701248104

Grollman, Arthur P., et al. "Aristolochic acid and the etiology of endemic (Balkan) nephropathy." Proceedings of the National Academy of Sciences, vol. 104, no. 29, 2007, pp. 12129-12134. https://doi.org/10.1073/pnas.0701248104

Grollman, Arthur P., Shinya Shibutani, Masaaki Moriya, Fredrick Miller, Lin Wu, Ute Moll, Naomi Suzuki, et al. "Aristolochic acid and the etiology of endemic (Balkan) nephropathy." Proceedings of the National Academy of Sciences 104, no. 29 (2007): 12129-12134. https://doi.org/10.1073/pnas.0701248104

Grollman, A. P., et al. (2007) 'Aristolochic acid and the etiology of endemic (Balkan) nephropathy', Proceedings of the National Academy of Sciences, 104(29), pp. 12129-12134. doi: 10.1073/pnas.0701248104

Grollman AP, Shibutani S, Moriya M, Miller F, Wu L, Moll U, and sur.. Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Proceedings of the National Academy of Sciences [Internet]. 2007 July 17 [cited 2024 May 04];104(29):12129-12134. doi: 10.1073/pnas.0701248104

A. P. Grollman, et al., "Aristolochic acid and the etiology of endemic (Balkan) nephropathy", Proceedings of the National Academy of Sciences, vol. 104, no. 29, pp. 12129-12134, July 2007. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:678870. [Accessed: 04 May 2024]

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Metadata
Title (english)Aristolochic acid and the etiology of endemic (Balkan) nephropathy
AuthorArthur P. Grollman
AuthorShinya Shibutani
AuthorMasaaki Moriya
AuthorFredrick Miller
AuthorLin Wu
AuthorUte Moll
AuthorNaomi Suzuki
AuthorAndrea Fernandes
AuthorThomas Rosenquist
AuthorZvonimir Medverec
AuthorKrunoslav Jakovina
AuthorBranko Brdar
AuthorNeda Slade
AuthorRobert J. Turesky
AuthorAngela K. Goodenough
AuthorRobert Rieger
AuthorMato Vukelić
AuthorBojan Jelaković
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Endemic (Balkan) nephropathy (EN), a devastating renal disease affecting men and women living in rural areas of Bosnia, Bulgaria, Croatia, Romania, and Serbia, is characterized by its insidious onset, invariable progression to chronic renal failure and a strong association with transitional cell (urothelial) carcinoma of the upper urinary tract. Significant epidemiologic features of EN include its focal occurrence in certain villages and a familial, but not inherited, pattern of disease. Our experiments test the hypothesis that chronic dietary poisoning by aristolochic acid is responsible for EN and its associated urothelial cancer. Using (32)P-postlabeling/PAGE and authentic standards, we identified dA-aristolactam (AL) and dG-AL DNA adducts in the renal cortex of patients with EN but not in patients with other chronic renal diseases. In addition, urothelial cancer tissue was obtained from residents of endemic villages with upper urinary tract malignancies. The AmpliChip p53 microarray was then used to sequence exons 2-11 of the p53 gene where we identified 19 base substitutions. Mutations at A:T pairs accounted for 89% of all p53 mutations, with 78% of these being A:T --> T:A transversions. Our experimental results, namely, that (i) DNA adducts derived from aristolochic acid (AA) are present in renal tissues of patients with documented EN, (ii) these adducts can be detected in transitional cell cancers, and (iii) A:T --> T:A transversions dominate the p53 mutational spectrum in the upper urinary tract malignancies found in this population lead to the conclusion that dietary exposure to AA is a significant risk factor for EN and its attendant transitional cell cancer.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleProceedings of the National Academy of Sciences
Numberingvol. 104, no. 29, pp. 12129-12134
p-ISSN0027-8424
DOIhttps://doi.org/10.1073/pnas.0701248104
URN:NBNurn:nbn:hr:105:678870
Publication2007-07-17
Document URLhttps://doi.org/10.1073/pnas.0701248104
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:23:13