prikaz prve stranice dokumenta Aristolochic acid and the etiology of endemic (Balkan) nephropathy
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Aristolochic acid and the etiology of endemic (Balkan) nephropathy
Proceedings of the National Academy of Sciences, 104 (2007), 29; 12129-12134. https://doi.org/10.1073/pnas.0701248104
Grollman, Arthur P.; Shibutani, Shinya; Moriya, Masaaki; Miller, Fredrick; Wu, Lin; Moll, Ute; Suzuki, Naomi; Fernandes, Andrea; Rosenquist, Thomas; Medverec, Zvonimir; Jakovina, Krunoslav; Brdar, Branko; Slade, Neda; Turesky, Robert J.; Goodenough, Angela K.; Rieger, Robert; Vukelić, Mato; Jelaković, Bojan Više autora...

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Grollman, A. P., Shibutani, S., Moriya, M., Miller, F., Wu, L., Moll, U. ... Jelaković, B. (2007). Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Proceedings of the National Academy of Sciences, 104. (29), 12129-12134. doi: 10.1073/pnas.0701248104

Grollman, Arthur P., et al. "Aristolochic acid and the etiology of endemic (Balkan) nephropathy." Proceedings of the National Academy of Sciences, vol. 104, br. 29, 2007, str. 12129-12134. https://doi.org/10.1073/pnas.0701248104

Grollman, Arthur P., Shinya Shibutani, Masaaki Moriya, Fredrick Miller, Lin Wu, Ute Moll, Naomi Suzuki, et al. "Aristolochic acid and the etiology of endemic (Balkan) nephropathy." Proceedings of the National Academy of Sciences 104, br. 29 (2007): 12129-12134. https://doi.org/10.1073/pnas.0701248104

Grollman, A. P., et al. (2007) 'Aristolochic acid and the etiology of endemic (Balkan) nephropathy', Proceedings of the National Academy of Sciences, 104(29), str. 12129-12134. doi: 10.1073/pnas.0701248104

Grollman AP, Shibutani S, Moriya M, Miller F, Wu L, Moll U, i sur.. Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Proceedings of the National Academy of Sciences [Internet]. 17.07.2007. [pristupljeno 06.10.2024.];104(29):12129-12134. doi: 10.1073/pnas.0701248104

A. P. Grollman, et al., "Aristolochic acid and the etiology of endemic (Balkan) nephropathy", Proceedings of the National Academy of Sciences, vol. 104, br. 29, str. 12129-12134, Srpanj 2007. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:678870. [Citirano: 06.10.2024.]

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Naslov (engleski)Aristolochic acid and the etiology of endemic (Balkan) nephropathy
AutorArthur P. Grollman
AutorShinya Shibutani
AutorMasaaki Moriya
AutorFredrick Miller
AutorLin Wu
AutorUte Moll
AutorNaomi Suzuki
AutorAndrea Fernandes
AutorThomas Rosenquist
AutorZvonimir Medverec
AutorKrunoslav Jakovina
AutorBranko Brdar
AutorNeda Slade
AutorRobert J. Turesky
AutorAngela K. Goodenough
AutorRobert Rieger
AutorMato Vukelić
AutorBojan Jelaković
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Endemic (Balkan) nephropathy (EN), a devastating renal disease affecting men and women living in rural areas of Bosnia, Bulgaria, Croatia, Romania, and Serbia, is characterized by its insidious onset, invariable progression to chronic renal failure and a strong association with transitional cell (urothelial) carcinoma of the upper urinary tract. Significant epidemiologic features of EN include its focal occurrence in certain villages and a familial, but not inherited, pattern of disease. Our experiments test the hypothesis that chronic dietary poisoning by aristolochic acid is responsible for EN and its associated urothelial cancer. Using (32)P-postlabeling/PAGE and authentic standards, we identified dA-aristolactam (AL) and dG-AL DNA adducts in the renal cortex of patients with EN but not in patients with other chronic renal diseases. In addition, urothelial cancer tissue was obtained from residents of endemic villages with upper urinary tract malignancies. The AmpliChip p53 microarray was then used to sequence exons 2-11 of the p53 gene where we identified 19 base substitutions. Mutations at A:T pairs accounted for 89% of all p53 mutations, with 78% of these being A:T --> T:A transversions. Our experimental results, namely, that (i) DNA adducts derived from aristolochic acid (AA) are present in renal tissues of patients with documented EN, (ii) these adducts can be detected in transitional cell cancers, and (iii) A:T --> T:A transversions dominate the p53 mutational spectrum in the upper urinary tract malignancies found in this population lead to the conclusion that dietary exposure to AA is a significant risk factor for EN and its attendant transitional cell cancer.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaProceedings of the National Academy of Sciences
Brojčani podacivol. 104, br. 29, str. 12129-12134
p-ISSN0027-8424
DOIhttps://doi.org/10.1073/pnas.0701248104
URN:NBNurn:nbn:hr:105:678870
Datum objave publikacije2007-07-17
URL dokumentahttps://doi.org/10.1073/pnas.0701248104
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 09:23:13