prikaz prve stranice dokumenta Increased mean platelet volume (MPV) is an independent predictor of inferior survival in patients with primary and secondary myelofibrosis
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Scientific paper - Original scientific paper
Increased mean platelet volume (MPV) is an independent predictor of inferior survival in patients with primary and secondary myelofibrosis
International Journal of Hematology, 107 (2018), 2; 166-172. https://doi.org/10.1007/s12185-017-2348-4
Lucijanić, Marko; Mitrović, Zdravko; Čičić, David; Prka, Željko; Pejša, Vlatko; Livun, Ana; Štoos-Veić, Tajana; Romić, Željko; Živković, Marcela; Lucijanić, Iva; Fabris, Zrinka; Kušec, Rajko

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Lucijanić, M., Mitrović, Z., Čičić, D., Prka, Ž., Pejša, V., Livun, A. ... Kušec, R. (2018). Increased mean platelet volume (MPV) is an independent predictor of inferior survival in patients with primary and secondary myelofibrosis. International Journal of Hematology, 107. (2), 166-172. doi: 10.1007/s12185-017-2348-4

Lucijanić, Marko, et al. "Increased mean platelet volume (MPV) is an independent predictor of inferior survival in patients with primary and secondary myelofibrosis." International Journal of Hematology, vol. 107, no. 2, 2018, pp. 166-172. https://doi.org/10.1007/s12185-017-2348-4

Lucijanić, Marko, Zdravko Mitrović, David Čičić, Željko Prka, Vlatko Pejša, Ana Livun, Tajana Štoos Veić, et al. "Increased mean platelet volume (MPV) is an independent predictor of inferior survival in patients with primary and secondary myelofibrosis." International Journal of Hematology 107, no. 2 (2018): 166-172. https://doi.org/10.1007/s12185-017-2348-4

Lucijanić, M., et al. (2018) 'Increased mean platelet volume (MPV) is an independent predictor of inferior survival in patients with primary and secondary myelofibrosis', International Journal of Hematology, 107(2), pp. 166-172. doi: 10.1007/s12185-017-2348-4

Lucijanić M, Mitrović Z, Čičić D, Prka Ž, Pejša V, Livun A, and sur.. Increased mean platelet volume (MPV) is an independent predictor of inferior survival in patients with primary and secondary myelofibrosis. International Journal of Hematology [Internet]. 2018 February [cited 2024 December 20];107(2):166-172. doi: 10.1007/s12185-017-2348-4

M. Lucijanić, et al., "Increased mean platelet volume (MPV) is an independent predictor of inferior survival in patients with primary and secondary myelofibrosis", International Journal of Hematology, vol. 107, no. 2, pp. 166-172, February 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:626012. [Accessed: 20 December 2024]

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Metadata
Title (english)Increased mean platelet volume (MPV) is an independent predictor of inferior survival in patients with primary and secondary myelofibrosis
AuthorMarko Lucijanić
AuthorZdravko Mitrović
AuthorDavid Čičić
AuthorŽeljko Prka
AuthorVlatko Pejša
AuthorAna Livun
AuthorTajana Štoos-Veić
AuthorŽeljko Romić
AuthorMarcela Živković
AuthorIva Lucijanić
AuthorZrinka Fabris
AuthorRajko Kušec
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Neoplastic megakaryopoiesis is a dominant feature of Philadelphia-chromosome-negative myeloproliferative neoplasms (Ph- MPNs), and elevated mean-platelet-volume (MPV) is a common finding in these diseases. The clinical and prognostic significances of MPV in patients with primary (PMF) and secondary myelofibrosis (SMF) have not been reported. We retrospectively analyzed 87 patients with myelofibrosis (66 with PMF, 21 with SMF) treated at our institution. MPV was recorded in addition to other hematological and clinical parameters. MPV was elevated in both PMF and SMF patients in comparison to controls, whereas there was no statistically significant difference between PMF and SMF. Elevated MPV was associated with lower platelets (P = 0.016), higher white blood cells (P = 0.015), higher percentage of circulatory blasts (P = 0.009), higher lactate dehydrogenase (P = 0.011), larger spleen size (P = 0.014) and higher Dynamic International Prognostic score category (P = 0.027), while there was no statistically significant association with driver mutations or degree of bone marrow fibrosis. Higher MPV was univariately associated with inferior overall survival in the whole cohort (HR = 3.82, P = 0.006), PMF (HR = 4.35, P = 0.007) and SMF patients (HR = 7.22, P = 0.034). These associations remained significant in multivariate analyses adjusted for DIPSS. Higher MPV is associated with more aggressive disease features and exhibits powerful independent prognostic properties in both PMF and SMF settings.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleInternational Journal of Hematology
Numberingvol. 107, no. 2, pp. 166-172
p-ISSN0925-5710
DOIhttps://doi.org/10.1007/s12185-017-2348-4
URN:NBNurn:nbn:hr:105:626012
Publication2018-02
Document URLhttps://doi.org/10.1007/s12185-017-2348-4
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:23:43