prikaz prve stranice dokumenta Increased mean platelet volume (MPV) is an independent predictor of inferior survival in patients with primary and secondary myelofibrosis
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Increased mean platelet volume (MPV) is an independent predictor of inferior survival in patients with primary and secondary myelofibrosis
International Journal of Hematology, 107 (2018), 2; 166-172. https://doi.org/10.1007/s12185-017-2348-4
Lucijanić, Marko; Mitrović, Zdravko; Čičić, David; Prka, Željko; Pejša, Vlatko; Livun, Ana; Štoos-Veić, Tajana; Romić, Željko; Živković, Marcela; Lucijanić, Iva; Fabris, Zrinka; Kušec, Rajko

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Lucijanić, M., Mitrović, Z., Čičić, D., Prka, Ž., Pejša, V., Livun, A. ... Kušec, R. (2018). Increased mean platelet volume (MPV) is an independent predictor of inferior survival in patients with primary and secondary myelofibrosis. International Journal of Hematology, 107. (2), 166-172. doi: 10.1007/s12185-017-2348-4

Lucijanić, Marko, et al. "Increased mean platelet volume (MPV) is an independent predictor of inferior survival in patients with primary and secondary myelofibrosis." International Journal of Hematology, vol. 107, br. 2, 2018, str. 166-172. https://doi.org/10.1007/s12185-017-2348-4

Lucijanić, Marko, Zdravko Mitrović, David Čičić, Željko Prka, Vlatko Pejša, Ana Livun, Tajana Štoos Veić, et al. "Increased mean platelet volume (MPV) is an independent predictor of inferior survival in patients with primary and secondary myelofibrosis." International Journal of Hematology 107, br. 2 (2018): 166-172. https://doi.org/10.1007/s12185-017-2348-4

Lucijanić, M., et al. (2018) 'Increased mean platelet volume (MPV) is an independent predictor of inferior survival in patients with primary and secondary myelofibrosis', International Journal of Hematology, 107(2), str. 166-172. doi: 10.1007/s12185-017-2348-4

Lucijanić M, Mitrović Z, Čičić D, Prka Ž, Pejša V, Livun A, i sur.. Increased mean platelet volume (MPV) is an independent predictor of inferior survival in patients with primary and secondary myelofibrosis. International Journal of Hematology [Internet]. 02.2018. [pristupljeno 30.12.2024.];107(2):166-172. doi: 10.1007/s12185-017-2348-4

M. Lucijanić, et al., "Increased mean platelet volume (MPV) is an independent predictor of inferior survival in patients with primary and secondary myelofibrosis", International Journal of Hematology, vol. 107, br. 2, str. 166-172, Veljača 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:626012. [Citirano: 30.12.2024.]

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Naslov (engleski)Increased mean platelet volume (MPV) is an independent predictor of inferior survival in patients with primary and secondary myelofibrosis
AutorMarko Lucijanić
AutorZdravko Mitrović
AutorDavid Čičić
AutorŽeljko Prka
AutorVlatko Pejša
AutorAna Livun
AutorTajana Štoos-Veić
AutorŽeljko Romić
AutorMarcela Živković
AutorIva Lucijanić
AutorZrinka Fabris
AutorRajko Kušec
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Neoplastic megakaryopoiesis is a dominant feature of Philadelphia-chromosome-negative myeloproliferative neoplasms (Ph- MPNs), and elevated mean-platelet-volume (MPV) is a common finding in these diseases. The clinical and prognostic significances of MPV in patients with primary (PMF) and secondary myelofibrosis (SMF) have not been reported. We retrospectively analyzed 87 patients with myelofibrosis (66 with PMF, 21 with SMF) treated at our institution. MPV was recorded in addition to other hematological and clinical parameters. MPV was elevated in both PMF and SMF patients in comparison to controls, whereas there was no statistically significant difference between PMF and SMF. Elevated MPV was associated with lower platelets (P = 0.016), higher white blood cells (P = 0.015), higher percentage of circulatory blasts (P = 0.009), higher lactate dehydrogenase (P = 0.011), larger spleen size (P = 0.014) and higher Dynamic International Prognostic score category (P = 0.027), while there was no statistically significant association with driver mutations or degree of bone marrow fibrosis. Higher MPV was univariately associated with inferior overall survival in the whole cohort (HR = 3.82, P = 0.006), PMF (HR = 4.35, P = 0.007) and SMF patients (HR = 7.22, P = 0.034). These associations remained significant in multivariate analyses adjusted for DIPSS. Higher MPV is associated with more aggressive disease features and exhibits powerful independent prognostic properties in both PMF and SMF settings.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaInternational Journal of Hematology
Brojčani podacivol. 107, br. 2, str. 166-172
p-ISSN0925-5710
DOIhttps://doi.org/10.1007/s12185-017-2348-4
URN:NBNurn:nbn:hr:105:626012
Datum objave publikacije2018-02
URL dokumentahttps://doi.org/10.1007/s12185-017-2348-4
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 09:23:43