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Scientific paper - Case study
Subcutaneous panniculitis-like T-cell lymphoma in a 19 month-old boy: a case report
Collegium Antropologicum, 34 (2010), 2; 679-682. urn:nbn:hr:105:378257
Rajić, Ljubica; Bilić, Ernest; Femenić, Ranka; Meštrović, Daniel; Ilić, Ivana; Lasan-Trčić, Ružica; Dubravčić, Klara; Husar, Karmela; Kardum-Skelin, Ika; Tešović, Goran; Čulig, Zdravka; Konja, Josip

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Rajić, Lj., Bilić, E., Femenić, R., Meštrović, D., Ilić, I., Lasan Trčić, R. ... Konja, J. (2010). Subcutaneous panniculitis-like T-cell lymphoma in a 19 month-old boy: a case report . Collegium Antropologicum, 34. (2), 679-682. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:378257

Rajić, Ljubica, et al. "Subcutaneous panniculitis-like T-cell lymphoma in a 19 month-old boy: a case report ." Collegium Antropologicum, vol. 34, no. 2, 2010, pp. 679-682. https://urn.nsk.hr/urn:nbn:hr:105:378257

Rajić, Ljubica, Ernest Bilić, Ranka Femenić, Daniel Meštrović, Ivana Ilić, Ružica Lasan Trčić, Klara Dubravčić, et al. "Subcutaneous panniculitis-like T-cell lymphoma in a 19 month-old boy: a case report ." Collegium Antropologicum 34, no. 2 (2010): 679-682. https://urn.nsk.hr/urn:nbn:hr:105:378257

Rajić, Lj., et al. (2010) 'Subcutaneous panniculitis-like T-cell lymphoma in a 19 month-old boy: a case report ', Collegium Antropologicum, 34(2), pp. 679-682. Available at: https://urn.nsk.hr/urn:nbn:hr:105:378257 (Accessed 03 May 2024)

Rajić Lj, Bilić E, Femenić R, Meštrović D, Ilić I, Lasan Trčić R, and sur.. Subcutaneous panniculitis-like T-cell lymphoma in a 19 month-old boy: a case report . Collegium Antropologicum [Internet]. 2010 June [cited 2024 May 03];34(2):679-682. Available at: https://urn.nsk.hr/urn:nbn:hr:105:378257

Lj. Rajić, et al., "Subcutaneous panniculitis-like T-cell lymphoma in a 19 month-old boy: a case report ", Collegium Antropologicum, vol. 34, no. 2, pp. 679-682, June 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:378257. [Accessed: 03 May 2024]

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Metadata
Title (english)Subcutaneous panniculitis-like T-cell lymphoma in a 19 month-old boy: a case report
Title (croatian)Potkožni T-stanični limfom nalik panikulitisu u 19-mjesečnog dječaka: prikaz slučaja
AuthorLjubica Rajić
AuthorErnest Bilić
AuthorRanka Femenić
AuthorDaniel Meštrović
AuthorIvana Ilić
AuthorRužica Lasan-Trčić
AuthorKlara Dubravčić
AuthorKarmela Husar
AuthorIka Kardum-Skelin
AuthorGoran Tešović
AuthorZdravka Čulig
AuthorJosip Konja
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare type of T-cell lymphoma of CD3+CD8+ phenotype characterized by deep-seated skin nodules or plaques mimicking panniculitis, a result of neoplastic lymphocytes infiltrating the subcutaneous fatty tissue. We present a case of a 19-month year old boy with SPTCL diagnosed and successfully treated in our institution. Disease first presented with symptoms of high fever and painful erythematous nodule located below the umbilicus. Later on the infiltrates appeared on the face, legs, arms and the back of the body. As the most decisive in obtaining the diagnosis, skin biopsy showed atypical, small to medium-sized lymphatic cells infiltrating the deeper dermal layers as well as the subcutaneous adipous tissue surrounding the adipocytes. Immunohystochemical analysis showed neoplastic lymphocytes positive for CD2, CD3, CD5, CD7, CD8, Tia-1, granzyme B and perforine, and negative for CD20, CD34, TDT and CD56. No infiltration of blood vessels or epidermis was evident. Specific T-cell lymphomas protocol (EURO-LB 02) was then initiated which resulted with rapid regression of all general and local symptoms. The treatment was completed according to schedule and the child is now, 24 months after the initiation of the treatment, in complete remission.
Abstract (croatian)
Potkožni T-stanični limfom nalik panikulitisu (engl. subcutaneous panniculitis-like T-cell lymphoma, SPTCL) jest rijetki oblik T-staničnog limfoma fenotipa CD3+CD8+ kojeg karakteriziraju duboki kožni čvorići ili plakovi nalik panniculitisu, a koji nastaju kao rezultat infiltracije potkožnog masnog tkiva neoplastičnim limfocitima. U ovom radu prikazujemo slučaj 19-mjesečnog dječaka sa SPTCL koji je dijagnosticiran i uspješno liječen u našoj ustanovi. Bolest se isprva prezentirala visokom vručicom i bolnim eritematoznim čvorićima ispod pupka. Kasnije su se infiltrati pojavili na licu, nogama, rukama i leđima. U postavljanju dijagnoze najodlučniji je bio patohistološki nalaz biopsije kože koji je pokazao infiltraciju atipičnih, malenih do srednje velikih limfatičnih stanica u dubljim slojevima dermisa i potkožnom tkivu oko adipocita. Na imunohistokemijskoj analizi neoplastični limfociti su izražavali biljege CD2, CD3, CD5, CD7, CD8, Tia-1, granzim-B i perforin, a bili su negativni na CD20, CD34, TDT i CD56. Nije nađena infiltracija krvnih žila i epidermisa. U djeteta je započeto liječenje protokolom specifičnim za T-stanične limfome (EURO-LB 02) što je uskoro dovelo do brzog povlačenja svih općih i lokalnih simptoma. Liječenje je završeno prema planu, a dijete je danas, 24 mjeseca od početka terapije u kompletnoj remisiji bolesti.
Keywords (english)
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 34, no. 2, pp. 679-682
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:378257
Publication2010-06
Document URLhttps://hrcak.srce.hr/56527
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:54:18