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Sex Differences in Clinical Characteristics and Outcomes After Myocardial Infarction With Low Ejection Fraction: Insights From PARADISE‐MI
Journal of the American Heart Association, 12 (2023), 17; e028942. https://doi.org/10.1161/JAHA.122.028942
Wang, Xiaowen; Jering, Karola S.; Čikeš, Maja; Tokmakova, Mariya P.; Mehran, Roxana; Han, Yaling; East, Cara; Mody, Freny Vaghaiwalla; Wang, Yi; Lewis, Eldrin F.; Claggett, Brian; McMurray, John J. V.; Granger, Christopher B.; Pfeffer, Marc A.; Solomon, Scott D. Više autora...

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Wang, X., Jering, K. S., Čikeš, M., Tokmakova, M. P., Mehran, R., Han, Y. ... Solomon, S. D. (2023). Sex Differences in Clinical Characteristics and Outcomes After Myocardial Infarction With Low Ejection Fraction: Insights From PARADISE‐MI. Journal of the American Heart Association, 12. (17). doi: 10.1161/JAHA.122.028942

Wang, Xiaowen, et al. "Sex Differences in Clinical Characteristics and Outcomes After Myocardial Infarction With Low Ejection Fraction: Insights From PARADISE‐MI." Journal of the American Heart Association, vol. 12, br. 17, 2023. https://doi.org/10.1161/JAHA.122.028942

Wang, Xiaowen, Karola S. Jering, Maja Čikeš, Mariya P. Tokmakova, Roxana Mehran, Yaling Han, Cara East, et al. "Sex Differences in Clinical Characteristics and Outcomes After Myocardial Infarction With Low Ejection Fraction: Insights From PARADISE‐MI." Journal of the American Heart Association 12, br. 17 (2023). https://doi.org/10.1161/JAHA.122.028942

Wang, X., et al. (2023) 'Sex Differences in Clinical Characteristics and Outcomes After Myocardial Infarction With Low Ejection Fraction: Insights From PARADISE‐MI', Journal of the American Heart Association, 12(17). doi: 10.1161/JAHA.122.028942

Wang X, Jering KS, Čikeš M, Tokmakova MP, Mehran R, Han Y, i sur.. Sex Differences in Clinical Characteristics and Outcomes After Myocardial Infarction With Low Ejection Fraction: Insights From PARADISE‐MI. Journal of the American Heart Association [Internet]. 05.09.2023. [pristupljeno 19.03.2025.];12(17). doi: 10.1161/JAHA.122.028942

X. Wang, et al., "Sex Differences in Clinical Characteristics and Outcomes After Myocardial Infarction With Low Ejection Fraction: Insights From PARADISE‐MI", Journal of the American Heart Association, vol. 12, br. 17, Rujan 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:310370. [Citirano: 19.03.2025.]

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Podaci o radu
Naslov (engleski)Sex Differences in Clinical Characteristics and Outcomes After Myocardial Infarction With Low Ejection Fraction: Insights From PARADISE‐MI
AutorXiaowen Wang
AutorKarola S. Jering
AutorMaja Čikeš
AutorMariya P. Tokmakova
AutorRoxana Mehran
AutorYaling Han
AutorCara East
AutorFreny Vaghaiwalla Mody
AutorYi Wang
AutorEldrin F. Lewis
AutorBrian Claggett
AutorJohn J. V. McMurray
AutorChristopher B. Granger
AutorMarc A. Pfeffer
AutorScott D. Solomon
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Background Studies demonstrated sex differences in outcomes following acute myocardial infarction, with women more likely to develop heart failure (HF). Sacubitril/valsartan has been shown to reduce cardiovascular death and HF hospitalizations in patients with HF with reduced ejection fraction. Methods and Results A total of 5661 patients (1363 women [24%]) with acute myocardial infarction complicated by reduced left ventricular ejection fraction (≤40%), pulmonary congestion, or both and ≥1 of 8 risk-augmenting factors were randomized to receive sacubitril/valsartan or ramipril. The primary outcome was cardiovascular death or incident HF. Baseline characteristics, clinical outcomes, and safety events were compared according to sex, a prespecified subgroup. Female participants were older and had more comorbidities. After multivariable adjustment, women and men were at similar risks for cardiovascular death or all-cause death. Women were more likely to have first HF hospitalization (hazard ratio [HR], 1.34 [95% CI, 1.05-1.70]; P=0.02) and total HF hospitalizations (HR, 1.39 [95% CI, 1.05-1.84]; P=0.02). Sex did not significantly modify the treatment effect of sacubitril/valsartan compared with ramipril on the primary outcome (P for interaction=0.11). Conclusions In contemporary patients who presented with reduced left ventricular ejection fraction, pulmonary congestion, or both, following acute myocardial infarction, women had a higher incidence of HF during follow-up. Sex did not modify the treatment effect of sacubitril/valsartan relative to ramipril.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of the American Heart Association
Brojčani podacivol. 12, br. 17, e028942
e-ISSN2047-9980
DOIhttps://doi.org/10.1161/JAHA.122.028942
URN:NBNurn:nbn:hr:105:310370
Datum objave publikacije2023-09-05
URL dokumentahttps://www.ahajournals.org/doi/10.1161/JAHA.122.028942
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2024-08-26 07:54:14