prikaz prve stranice dokumenta Estimated plasma volume status in COVID-19 patients and its relation to comorbidities and clinical outcomes
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Estimated plasma volume status in COVID-19 patients and its relation to comorbidities and clinical outcomes
Journal of Thrombosis and Thrombolysis, 57 (2023), 1; 50-57. https://doi.org/10.1007/s11239-023-02882-y
Lucijanić, Marko; Krečak, Ivan; Bušić, Iva; Atić, Armin; Stojić, Josip; Sabljić, Anica; Sorić, Ena; Veić, Petra; Marević, Sanja; Đerek, Lovorka; Mitrović, Joško; Lukšić, Ivica

Citirajte ovaj rad

Lucijanić, M., Krečak, I., Bušić, I., Atić, A., Stojić, J., Sabljić, A. ... Lukšić, I. (2023). Estimated plasma volume status in COVID-19 patients and its relation to comorbidities and clinical outcomes. Journal of Thrombosis and Thrombolysis, 57. (1), 50-57. doi: 10.1007/s11239-023-02882-y

Lucijanić, Marko, et al. "Estimated plasma volume status in COVID-19 patients and its relation to comorbidities and clinical outcomes." Journal of Thrombosis and Thrombolysis, vol. 57, br. 1, 2023, str. 50-57. https://doi.org/10.1007/s11239-023-02882-y

Lucijanić, Marko, Ivan Krečak, Iva Bušić, Armin Atić, Josip Stojić, Anica Sabljić, Ena Sorić, et al. "Estimated plasma volume status in COVID-19 patients and its relation to comorbidities and clinical outcomes." Journal of Thrombosis and Thrombolysis 57, br. 1 (2023): 50-57. https://doi.org/10.1007/s11239-023-02882-y

Lucijanić, M., et al. (2023) 'Estimated plasma volume status in COVID-19 patients and its relation to comorbidities and clinical outcomes', Journal of Thrombosis and Thrombolysis, 57(1), str. 50-57. doi: 10.1007/s11239-023-02882-y

Lucijanić M, Krečak I, Bušić I, Atić A, Stojić J, Sabljić A, i sur.. Estimated plasma volume status in COVID-19 patients and its relation to comorbidities and clinical outcomes. Journal of Thrombosis and Thrombolysis [Internet]. 12.08.2023. [pristupljeno 03.12.2024.];57(1):50-57. doi: 10.1007/s11239-023-02882-y

M. Lucijanić, et al., "Estimated plasma volume status in COVID-19 patients and its relation to comorbidities and clinical outcomes", Journal of Thrombosis and Thrombolysis, vol. 57, br. 1, str. 50-57, Kolovoz 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:511531. [Citirano: 03.12.2024.]

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Podaci o radu
Naslov (engleski)Estimated plasma volume status in COVID-19 patients and its relation to comorbidities and clinical outcomes
AutorMarko Lucijanić
AutorIvan Krečak
AutorIva Bušić
AutorArmin Atić
AutorJosip Stojić
AutorAnica Sabljić
AutorEna Sorić
AutorPetra Veić
AutorSanja Marević
AutorLovorka Đerek
AutorJoško Mitrović
AutorIvica Lukšić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MAKSILOFACIJALNU KIRURGIJU SA STOMATOLOGIJOM)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Sažetak (engleski)
Blood plasma is a large reservoir of circulating mediators of inflammation and its expansion has been associated with unfavorable outcomes in patients with inflammatory and cardiovascular diseases. The aim of this study was to determine clinical and prognostic value of estimated plasma volume status (ePVS) in hospitalized patients with COVID-19. We retrospectively investigated 5871 consecutive COVID-19 patient hospitalized in our tertiary-level institution in period 3/2020-6/2021. ePVS was determined using the Strauss-derived Duarte formula and was correlated with clinical characteristics and unwanted outcomes. Median ePVS was 4.77 dl/g with interquartile range 4.11-5.74. Higher ePVS was significantly associated with older age, female sex, higher comorbidity burden, worse functional status, less severe COVID-19 clinical presentation with lower severity and longer duration of symptoms, but more pronounced inflammatory profile with higher C-reactive protein, interleukin-6 and D-dimer levels (P < 0.05 for all analyses). In the multivariate regression analysis U shaped relationship of ePVS with mortality was revealed, present independently of age, sex, COVID-19 severity and comorbidity burden. In addition, higher ePVS was independently associated with higher tendency for mechanical ventilation, intensive care unit treatment, venous thromboembolism, major bleeding and bacteriemia and lower ePVS was independently associated with tendency for arterial thrombotic events. Higher ePVS, indicative of plasma volume expansion and inflammatory cytokine accumulation, may predispose respiratory deterioration and venous thromboembolism, despite less severe initial clinical presentation. Lower ePVS, indicative of hemoconcentration, may predispose arterial thrombotic events. Both may be associated with higher mortality in hospitalized COVID-19 patients.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaJournal of Thrombosis and Thrombolysis
Brojčani podacivol. 57, br. 1, str. 50-57
e-ISSN1573-742X
DOIhttps://doi.org/10.1007/s11239-023-02882-y
URN:NBNurn:nbn:hr:105:511531
Datum objave publikacije2023-08-12
URL dokumentahttps://link.springer.com/10.1007/s11239-023-02882-y
Vrsta resursaTekst
Prava pristupaPristup ograničen embargom
Datum isteka embarga: 2025-02-01
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-09-03 11:33:22