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The Role of Genetic Risk Factors in Pathogenesis of Childhood-Onset Systemic Lupus Erythematosus
Current Issues in Molecular Biology, 45 (2023), 7; 5981-6002. https://doi.org/10.3390/cimb45070378
Šestan, Mario; Kifer, Nastasia; Arsov, Todor; Cook, Matthew; Ellyard, Julia; Vinuesa, Carola G.; Jelušić, Marija

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Šestan, M., Kifer, N., Arsov, T., Cook, M., Ellyard, J., Vinuesa, C. G. i Jelušić, M. (2023). The Role of Genetic Risk Factors in Pathogenesis of Childhood-Onset Systemic Lupus Erythematosus. Current Issues in Molecular Biology, 45. (7), 5981-6002. doi: 10.3390/cimb45070378

Šestan, Mario, et al. "The Role of Genetic Risk Factors in Pathogenesis of Childhood-Onset Systemic Lupus Erythematosus." Current Issues in Molecular Biology, vol. 45, br. 7, 2023, str. 5981-6002. https://doi.org/10.3390/cimb45070378

Šestan, Mario, Nastasia Kifer, Todor Arsov, Matthew Cook, Julia Ellyard, Carola G. Vinuesa i Marija Jelušić. "The Role of Genetic Risk Factors in Pathogenesis of Childhood-Onset Systemic Lupus Erythematosus." Current Issues in Molecular Biology 45, br. 7 (2023): 5981-6002. https://doi.org/10.3390/cimb45070378

Šestan, M., et al. (2023) 'The Role of Genetic Risk Factors in Pathogenesis of Childhood-Onset Systemic Lupus Erythematosus', Current Issues in Molecular Biology, 45(7), str. 5981-6002. doi: 10.3390/cimb45070378

Šestan M, Kifer N, Arsov T, Cook M, Ellyard J, Vinuesa CG, i sur.. The Role of Genetic Risk Factors in Pathogenesis of Childhood-Onset Systemic Lupus Erythematosus. Current Issues in Molecular Biology [Internet]. 17.07.2023. [pristupljeno 08.10.2024.];45(7):5981-6002. doi: 10.3390/cimb45070378

M. Šestan, et al., "The Role of Genetic Risk Factors in Pathogenesis of Childhood-Onset Systemic Lupus Erythematosus", Current Issues in Molecular Biology, vol. 45, br. 7, str. 5981-6002, Srpanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:997251. [Citirano: 08.10.2024.]

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Naslov (engleski)The Role of Genetic Risk Factors in Pathogenesis of Childhood-Onset Systemic Lupus Erythematosus
AutorMario Šestan
AutorNastasia Kifer
AutorTodor Arsov
AutorMatthew Cook
AutorJulia Ellyard
AutorCarola G. Vinuesa
AutorMarija Jelušić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PEDIJATRIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Pedijatrija
Sažetak (engleski)
The pathogenesis of childhood-onset systemic lupus erythematosus (cSLE) is complex and not fully understood. It involves three key factors: genetic risk factors, epigenetic mechanisms, and environmental triggers. Genetic factors play a significant role in the development of the disease, particularly in younger individuals. While cSLE has traditionally been considered a polygenic disease, it is now recognized that in rare cases, a single gene mutation can lead to the disease. Although these cases are uncommon, they provide valuable insights into the disease mechanism, enhance our understanding of pathogenesis and immune tolerance, and facilitate the development of targeted treatment strategies. This review aims to provide a comprehensive overview of both monogenic and polygenic SLE, emphasizing the implications of specific genes in disease pathogenesis. By conducting a thorough analysis of the genetic factors involved in SLE, we can improve our understanding of the underlying mechanisms of the disease. Furthermore, this knowledge may contribute to the identification of effective biomarkers and the selection of appropriate therapies for individuals with SLE.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCurrent Issues in Molecular Biology
Brojčani podacivol. 45, br. 7, str. 5981-6002
e-ISSN1467-3045
DOIhttps://doi.org/10.3390/cimb45070378
URN:NBNurn:nbn:hr:105:997251
Datum objave publikacije2023-07-17
URL dokumentahttps://www.mdpi.com/1467-3045/45/7/378
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-09-19 10:41:27