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Metabolic activity of CYP2C19 and CYP2D6 on antidepressant response from 13 clinical studies using genotype imputation: a meta-analysis
Translational Psychiatry, 14 (2024), 1; 296. https://doi.org/10.1038/s41398-024-02981-1
(GSRD Consortium, the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium) Li, Danyang; Pain, Oliver; Fabbri, Chiara; Wong, Win Lee Edwin; Lo, Chris Wai Hang; Ripke, Stephan; Cattaneo, Annamaria; Souery, Daniel; Dernovsek, Mojca Z.; Henigsberg, Neven; Hauser, Joanna; Lewis, Glyn; Mors, Ole; Perroud, Nader; Rietschel, Marcella; Uher, Rudolf; Maier, Wolfgang; Baune, Bernhard T.; Biernacka, Joanna M.; Bondolfi, Guido; Domschke, Katharina; Kato, Masaki; Liu, Yu-Li; Serretti, Alessandro; Tsai, Shih-Jen; Weinshilboum, Richard; McIntosh, Andrew M.; Lewis, Cathryn M. Više autora...

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Li, D., Pain, O., Fabbri, C., Wong, W. L. E., Lo, C. W. H., Ripke, S. ... Lewis, C. M. (2024). Metabolic activity of CYP2C19 and CYP2D6 on antidepressant response from 13 clinical studies using genotype imputation: a meta-analysis. Translational Psychiatry, 14. (1). doi: 10.1038/s41398-024-02981-1

Li, Danyang, et al. "Metabolic activity of CYP2C19 and CYP2D6 on antidepressant response from 13 clinical studies using genotype imputation: a meta-analysis." Translational Psychiatry, vol. 14, br. 1, 2024. https://doi.org/10.1038/s41398-024-02981-1

Li, Danyang, Oliver Pain, Chiara Fabbri, Win Lee Edwin Wong, Chris Wai Hang Lo, Stephan Ripke, Annamaria Cattaneo, et al. "Metabolic activity of CYP2C19 and CYP2D6 on antidepressant response from 13 clinical studies using genotype imputation: a meta-analysis." Translational Psychiatry 14, br. 1 (2024). https://doi.org/10.1038/s41398-024-02981-1

Li, D., et al. (2024) 'Metabolic activity of CYP2C19 and CYP2D6 on antidepressant response from 13 clinical studies using genotype imputation: a meta-analysis', Translational Psychiatry, 14(1). doi: 10.1038/s41398-024-02981-1

Li D, Pain O, Fabbri C, Wong WLE, Lo CWH, Ripke S, i sur.. Metabolic activity of CYP2C19 and CYP2D6 on antidepressant response from 13 clinical studies using genotype imputation: a meta-analysis. Translational Psychiatry [Internet]. 19.07.2024. [pristupljeno 04.10.2024.];14(1). doi: 10.1038/s41398-024-02981-1

D. Li, et al., "Metabolic activity of CYP2C19 and CYP2D6 on antidepressant response from 13 clinical studies using genotype imputation: a meta-analysis", Translational Psychiatry, vol. 14, br. 1, Srpanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:412499. [Citirano: 04.10.2024.]

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Podaci o radu
Naslov (engleski)Metabolic activity of CYP2C19 and CYP2D6 on antidepressant response from 13 clinical studies using genotype imputation: a meta-analysis
AutorDanyang Li
AutorOliver Pain
AutorChiara Fabbri
AutorWin Lee Edwin Wong
AutorChris Wai Hang Lo
AutorStephan Ripke
AutorAnnamaria Cattaneo
AutorDaniel Souery
AutorMojca Z. Dernovsek
AutorNeven Henigsberg
AutorJoanna Hauser
AutorGlyn Lewis
AutorOle Mors
AutorNader Perroud
AutorMarcella Rietschel
AutorRudolf Uher
AutorWolfgang Maier
AutorBernhard T. Baune
AutorJoanna M. Biernacka
AutorGuido Bondolfi
AutorKatharina Domschke
AutorMasaki Kato
AutorYu-Li Liu
AutorAlessandro Serretti
AutorShih-Jen Tsai
AutorRichard Weinshilboum
AutorAndrew M. McIntosh
AutorCathryn M. Lewis
KolaboracijaGSRD Consortium, the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PSIHIJATRIJU I PSIHOLOŠKU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Sažetak (engleski)
Cytochrome P450 enzymes including CYP2C19 and CYP2D6 are important for antidepressant metabolism and polymorphisms of these genes have been determined to predict metabolite levels. Nonetheless, more evidence is needed to understand the impact of genetic variations on antidepressant response. In this study, individual clinical and genetic data from 13 studies of European and East Asian ancestry populations were collected. The antidepressant response was clinically assessed as remission and percentage improvement. Imputed genotype was used to translate genetic polymorphisms to metabolic phenotypes (poor, intermediate, normal, and rapid+ultrarapid) of CYP2C19 and CYP2D6. CYP2D6 structural variants cannot be imputed from genotype data, limiting the determination of metabolic phenotypes, and precluding testing for association with response. The association of CYP2C19 metabolic phenotypes with treatment response was examined using normal metabolizers as the reference. Among 5843 depression patients, a higher remission rate was found in CYP2C19 poor metabolizers compared to normal metabolizers at nominal significance but did not survive after multiple testing correction (OR = 1.46, 95% CI [1.03, 2.06], p = 0.033, heterogeneity I2 = 0%, subgroup difference p = 0.72). No metabolic phenotype was associated with percentage improvement from baseline. After stratifying by antidepressants primarily metabolized by CYP2C19, no association was found between metabolic phenotypes and antidepressant response. Metabolic phenotypes showed differences in frequency, but not effect, between European- and East Asian-ancestry studies. In conclusion, metabolic phenotypes imputed from genetic variants using genotype were not associated with antidepressant response. CYP2C19 poor metabolizers could potentially contribute to antidepressant efficacy with more evidence needed. Sequencing and targeted pharmacogenetic testing, alongside information on side effects, antidepressant dosage, depression measures, and diverse ancestry studies, would more fully capture the influence of metabolic phenotypes.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaTranslational Psychiatry
Brojčani podacivol. 14, br. 1, 296
e-ISSN2158-3188
DOIhttps://doi.org/10.1038/s41398-024-02981-1
URN:NBNurn:nbn:hr:105:412499
Datum objave publikacije2024-07-19
URL dokumentahttps://www.nature.com/articles/s41398-024-02981-1
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-09-26 09:04:35