prikaz prve stranice dokumenta Serum Levels of Adiponectin Are Strongly Associated with Lipoprotein Subclasses in Healthy Volunteers but Not in Patients with Metabolic Syndrome
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Serum Levels of Adiponectin Are Strongly Associated with Lipoprotein Subclasses in Healthy Volunteers but Not in Patients with Metabolic Syndrome
International Journal of Molecular Sciences, 25 (2024), 9; 5050. https://doi.org/10.3390/ijms25095050
Klobučar, Iva; Habisch, Hansjörg; Klobučar, Lucija; Trbušić, Matias; Pregartner, Gudrun; Berghold, Andrea; Kostner, Gerhard M.; Scharnagl, Hubert; Madl, Tobias; Frank, Saša; Degoricija, Vesna

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Klobučar, I., Habisch, H., Klobučar, L., Trbušić, M., Pregartner, G., Berghold, A. ... Degoricija, V. (2024). Serum Levels of Adiponectin Are Strongly Associated with Lipoprotein Subclasses in Healthy Volunteers but Not in Patients with Metabolic Syndrome. International Journal of Molecular Sciences, 25. (9). doi: 10.3390/ijms25095050

Klobučar, Iva, et al. "Serum Levels of Adiponectin Are Strongly Associated with Lipoprotein Subclasses in Healthy Volunteers but Not in Patients with Metabolic Syndrome." International Journal of Molecular Sciences, vol. 25, br. 9, 2024. https://doi.org/10.3390/ijms25095050

Klobučar, Iva, Hansjörg Habisch, Lucija Klobučar, Matias Trbušić, Gudrun Pregartner, Andrea Berghold, Gerhard M. Kostner, et al. "Serum Levels of Adiponectin Are Strongly Associated with Lipoprotein Subclasses in Healthy Volunteers but Not in Patients with Metabolic Syndrome." International Journal of Molecular Sciences 25, br. 9 (2024). https://doi.org/10.3390/ijms25095050

Klobučar, I., et al. (2024) 'Serum Levels of Adiponectin Are Strongly Associated with Lipoprotein Subclasses in Healthy Volunteers but Not in Patients with Metabolic Syndrome', International Journal of Molecular Sciences, 25(9). doi: 10.3390/ijms25095050

Klobučar I, Habisch H, Klobučar L, Trbušić M, Pregartner G, Berghold A, i sur.. Serum Levels of Adiponectin Are Strongly Associated with Lipoprotein Subclasses in Healthy Volunteers but Not in Patients with Metabolic Syndrome. International Journal of Molecular Sciences [Internet]. 06.05.2024. [pristupljeno 21.02.2025.];25(9). doi: 10.3390/ijms25095050

I. Klobučar, et al., "Serum Levels of Adiponectin Are Strongly Associated with Lipoprotein Subclasses in Healthy Volunteers but Not in Patients with Metabolic Syndrome", International Journal of Molecular Sciences, vol. 25, br. 9, Svibanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:205726. [Citirano: 21.02.2025.]

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Naslov (engleski)Serum Levels of Adiponectin Are Strongly Associated with Lipoprotein Subclasses in Healthy Volunteers but Not in Patients with Metabolic Syndrome
AutorIva Klobučar
AutorHansjörg Habisch
AutorLucija Klobučar
AutorMatias Trbušić
AutorGudrun Pregartner
AutorAndrea Berghold
AutorGerhard M. Kostner
AutorHubert Scharnagl
AutorTobias Madl
AutorSaša Frank
AutorVesna Degoricija
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Metabolic syndrome (MS) is a widespread disease in developed countries, accompanied, among others, by decreased adiponectin serum levels and perturbed lipoprotein metabolism. The associations between the serum levels of adiponectin and lipoproteins have been extensively studied in the past under healthy conditions, yet it remains unexplored whether the observed associations also exist in patients with MS. Therefore, in the present study, we analyzed the serum levels of lipoprotein subclasses using nuclear magnetic resonance spectroscopy and examined their associations with the serum levels of adiponectin in patients with MS in comparison with healthy volunteers (HVs). In the HVs, the serum levels of adiponectin were significantly negatively correlated with the serum levels of large buoyant-, very-low-density lipoprotein, and intermediate-density lipoprotein, as well as small dense low-density lipoprotein (LDL) and significantly positively correlated with large buoyant high-density lipoprotein (HDL). In patients with MS, however, adiponectin was only significantly correlated with the serum levels of phospholipids in total HDL and large buoyant LDL. As revealed through logistic regression and orthogonal partial least-squares discriminant analyses, high adiponectin serum levels were associated with low levels of small dense LDL and high levels of large buoyant HDL in the HVs as well as high levels of large buoyant LDL and total HDL in patients with MS. We conclude that the presence of MS weakens or abolishes the strong associations between adiponectin and the lipoprotein parameters observed in HVs and disturbs the complex interplay between adiponectin and lipoprotein metabolism.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 25, br. 9, 5050
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms25095050
URN:NBNurn:nbn:hr:105:205726
Datum objave publikacije2024-05-06
URL dokumentahttps://www.mdpi.com/1422-0067/25/9/5050
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-02-19 14:51:33