prikaz prve stranice dokumenta Insight into the Interplay of Gd-IgA1, HMGB1, RAGE and PCDH1 in IgA Vasculitis (IgAV)
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Insight into the Interplay of Gd-IgA1, HMGB1, RAGE and PCDH1 in IgA Vasculitis (IgAV)
International Journal of Molecular Sciences, 25 (2024), 8; 4383. https://doi.org/10.3390/ijms25084383
Held, Martina; Kozmar, Ana; Šestan, Mario; Turudić, Daniel; Kifer, Nastasia; Sršen, Saša; Gagro, Alenka; Frković, Marijan; Jelušić, Marija

Citirajte ovaj rad

Held, M., Kozmar, A., Šestan, M., Turudić, D., Kifer, N., Sršen, S. ... Jelušić, M. (2024). Insight into the Interplay of Gd-IgA1, HMGB1, RAGE and PCDH1 in IgA Vasculitis (IgAV). International Journal of Molecular Sciences, 25. (8). doi: 10.3390/ijms25084383

Held, Martina, et al. "Insight into the Interplay of Gd-IgA1, HMGB1, RAGE and PCDH1 in IgA Vasculitis (IgAV)." International Journal of Molecular Sciences, vol. 25, br. 8, 2024. https://doi.org/10.3390/ijms25084383

Held, Martina, Ana Kozmar, Mario Šestan, Daniel Turudić, Nastasia Kifer, Saša Sršen, Alenka Gagro, Marijan Frković i Marija Jelušić. "Insight into the Interplay of Gd-IgA1, HMGB1, RAGE and PCDH1 in IgA Vasculitis (IgAV)." International Journal of Molecular Sciences 25, br. 8 (2024). https://doi.org/10.3390/ijms25084383

Held, M., et al. (2024) 'Insight into the Interplay of Gd-IgA1, HMGB1, RAGE and PCDH1 in IgA Vasculitis (IgAV)', International Journal of Molecular Sciences, 25(8). doi: 10.3390/ijms25084383

Held M, Kozmar A, Šestan M, Turudić D, Kifer N, Sršen S, i sur.. Insight into the Interplay of Gd-IgA1, HMGB1, RAGE and PCDH1 in IgA Vasculitis (IgAV). International Journal of Molecular Sciences [Internet]. 16.04.2024. [pristupljeno 13.03.2025.];25(8). doi: 10.3390/ijms25084383

M. Held, et al., "Insight into the Interplay of Gd-IgA1, HMGB1, RAGE and PCDH1 in IgA Vasculitis (IgAV)", International Journal of Molecular Sciences, vol. 25, br. 8, Travanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:217666. [Citirano: 13.03.2025.]

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Podaci o radu
Naslov (engleski)Insight into the Interplay of Gd-IgA1, HMGB1, RAGE and PCDH1 in IgA Vasculitis (IgAV)
AutorMartina Held
AutorAna Kozmar
AutorMario Šestan
AutorDaniel Turudić
AutorNastasia Kifer
AutorSaša Sršen
AutorAlenka Gagro
AutorMarijan Frković
AutorMarija Jelušić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PEDIJATRIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Pedijatrija
Sažetak (engleski)
The pathogenesis of IgAV, the most common systemic vasculitis in childhood, appears to be complex and requires further elucidation. We aimed to investigate the potential role of galactose-deficient immunoglobulin A1 (Gd-IgA1), high-mobility group box 1 (HMGB1), receptor for advanced glycation end products (RAGE) and protocadherin 1 (PCDH1) in the pathogenesis of IgAV. Our prospective study enrolled 86 patients with IgAV and 70 controls. HMGB1, RAGE, Gd-IgA1 and PCDH1 in serum and urine were determined by the enzyme-linked immunosorbent assay (ELISA) method at the onset of the disease and after a six-month interval in patients and once in the control group. Serum concentrations of HMGB1, RAGE and PCDH1 and urinary concentrations of HMGB1, RAGE, Gd-IgA1 and PCDH1 were significantly higher in patients with IgAV than in the control group (p < 0.001). Concentrations of HMGB1 (5573 pg/mL vs. 3477 pg/mL vs. 1088 pg/mL, p < 0.001) and RAGE (309 pg/mL vs. 302.4 pg/mL vs. 201.3 pg/mL, p = 0.012) in the serum of patients remained significantly elevated when the disease onset was compared with the six-month follow-up interval, and thus could be a potential marker of disease activity. Urinary concentration of HMGB1 measured in the follow-up period was higher in patients with nephritis compared to IgAV without nephritis (270.9 (146.7–542.7) ng/mmol vs. 133.2 (85.9–318.6) ng/mmol, p = 0.049) and significantly positively correlated with the urine albumine to creatinine ratio (τ = 0.184, p < 0.05), the number of erythrocytes in urine samples (τ = 0.193, p < 0.05) and with the outcome of nephritis (τ = 0.287, p < 0.05); therefore, HMGB1 could be a potential tool for monitoring patients with IgAV who develop nephritis. Taken together, our results imply a possible interplay of Gd-IgA1, HMGB1, RAGE and PCDH1 in the development of IgAV. The identification of sensitive biomarkers in IgAV may provide disease prevention and future therapeutics.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 25, br. 8, 4383
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms25084383
URN:NBNurn:nbn:hr:105:217666
Datum objave publikacije2024-04-16
URL dokumentahttps://www.mdpi.com/1422-0067/25/8/4383
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-03-03 08:54:02