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PDF 253.26 KB
diplomski rad
11
18
ALLOGENEIC TRANSPLANTATION FROM HLA-HAPLOIDENTICAL DONORS IN KBC ZAGREB
Brian Jacob Melamed (2016)
Sveučilište u Zagrebu
Medicinski fakultet
Za citiranje koristite ovu mrežnu adresu:
https://urn.nsk.hr/urn:nbn:hr:105:668860
Podaci o radu
Naslov
ALLOGENEIC TRANSPLANTATION FROM HLA-HAPLOIDENTICAL DONORS IN KBC ZAGREB
Autor
Brian Jacob Melamed
Voditelj/Mentor
Nadira Duraković
(mentor)
Sažetak rada
Background: The use of haploidentical stem cell transplantation (HSCT) has recently arisen as an effective treatment for refractory hematological malignancies, and several approaches have been shown to offer similar outcomes to HLA-matched allogeneic HSCT with the benefit of a larger and more accessible donor pool, particularly in smaller countries and ethnic minorities. High-dose post-transplant cyclophosphamide (PTCy) is a simple and well-studied approach being newly utilized at UHC Zagreb. Objective: We evaluated several key outcomes of patients receiving haploidentical HSCT at UHC Zagreb in order to determine whether they were acceptable in comparison to other centers performing haploidentical HSCT as well as studies of HLA-matched HSCT. Methods: In a retrospective study, ten patients with various refractory myelogenous and lymphoid malignancies underwent PTCy haploidentical HSCT at UHC Zagreb from 2012-2015. Both myeloablative and RIC conditioning regimens were employed. Data was collected towards the primary endpoints of engraftment, relapse and GVHD rates. Results: Median times to neutrophil and thrombocyte recovery were 12 and 21 days post-transplant, respectively. Relapse rates were 50%, with a mean relapse time of 5.6 months. Rejection rate was 10%. NRM was 20% with a median time of 15.3 months. Acute and chronic GVHD rates were 10% and 30% respectively, with a mean diagnosis time of 11.2 months for chronic GVHD. Conclusion: HLA-haploidentical HSCT at UHC Zagreb using PTCy is associated with acceptable rates of engraftment, relapse, and GVHD.
Ključne riječi
stem cell transplantation
haploidentical
graft-versus-host
post-transplantation cyclophosphamide
Povjerenstvo za obranu
Radovan Vrhovac
(predsjednik povjerenstva)
Jasenka Markeljević
(član povjerenstva)
Nadira Duraković
(član povjerenstva)
Ustanova koja je dodijelila akademski/stručni stupanj
Sveučilište u Zagrebu
Medicinski fakultet
Mjesto
Zagreb
Država obrane
Hrvatska
Znanstveno područje, polje, grana
BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Vrsta studija
sveučilišni
Stupanj
integrirani preddiplomski i diplomski
Naziv studijskog programa
Medicina (na engleskom jeziku)
Akademski / stručni naziv
doktor/doktorica medicine
Kratica akademskog / stručnog naziva
dr. med.
Vrsta rada
diplomski rad
Jezik
engleski
Datum obrane
2016-09-28
Vrsta resursa
tekst
Prava pristupa
Rad u otvorenom pristupu
Uvjeti korištenja rada
URN:NBN
https://urn.nsk.hr/urn:nbn:hr:105:668860
Pohranio
Ana Babić