prikaz prve stranice dokumenta Autism Spectrum Disorders: Multiple Routes to, and Multiple Consequences of, Abnormal Synaptic Function and Connectivity
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Autism Spectrum Disorders: Multiple Routes to, and Multiple Consequences of, Abnormal Synaptic Function and Connectivity
The Neuroscientist, 27 (2021), 1; 10-29. https://doi.org/10.1177/1073858420921378
Carroll, Liam; Braeutigam, Sven; Dawes, John M.; Krsnik, Željka; Kostović, Ivica; Coutinho, Ester; Dewing, Jennifer M.; Horton, Christopher A.; Gomez-Nicola, Diego; Menassa, David A.

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Carroll, L., Braeutigam, S., Dawes, J. M., Krsnik, Ž., Kostović, I., Coutinho, E. ... Menassa, D. A. (2021). Autism Spectrum Disorders: Multiple Routes to, and Multiple Consequences of, Abnormal Synaptic Function and Connectivity. The Neuroscientist, 27. (1), 10-29. doi: 10.1177/1073858420921378

Carroll, Liam, et al. "Autism Spectrum Disorders: Multiple Routes to, and Multiple Consequences of, Abnormal Synaptic Function and Connectivity." The Neuroscientist, vol. 27, br. 1, 2021, str. 10-29. https://doi.org/10.1177/1073858420921378

Carroll, Liam, Sven Braeutigam, John M. Dawes, Željka Krsnik, Ivica Kostović, Ester Coutinho, Jennifer M. Dewing, Christopher A. Horton, Diego Gomez Nicola i David A. Menassa. "Autism Spectrum Disorders: Multiple Routes to, and Multiple Consequences of, Abnormal Synaptic Function and Connectivity." The Neuroscientist 27, br. 1 (2021): 10-29. https://doi.org/10.1177/1073858420921378

Carroll, L., et al. (2021) 'Autism Spectrum Disorders: Multiple Routes to, and Multiple Consequences of, Abnormal Synaptic Function and Connectivity', The Neuroscientist, 27(1), str. 10-29. doi: 10.1177/1073858420921378

Carroll L, Braeutigam S, Dawes JM, Krsnik Ž, Kostović I, Coutinho E, i sur.. Autism Spectrum Disorders: Multiple Routes to, and Multiple Consequences of, Abnormal Synaptic Function and Connectivity. The Neuroscientist [Internet]. 02.2021. [pristupljeno 19.12.2024.];27(1):10-29. doi: 10.1177/1073858420921378

L. Carroll, et al., "Autism Spectrum Disorders: Multiple Routes to, and Multiple Consequences of, Abnormal Synaptic Function and Connectivity", The Neuroscientist, vol. 27, br. 1, str. 10-29, Veljača 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:570841. [Citirano: 19.12.2024.]

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Podaci o radu
Naslov (engleski)Autism Spectrum Disorders: Multiple Routes to, and Multiple Consequences of, Abnormal Synaptic Function and Connectivity
AutorLiam Carroll
AutorSven Braeutigam
AutorJohn M. Dawes
AutorŽeljka Krsnik
AutorIvica Kostović
AutorEster Coutinho
AutorJennifer M. Dewing
AutorChristopher A. Horton
AutorDiego Gomez-Nicola
AutorDavid A. Menassa
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Sažetak (engleski)
Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental disorders of genetic and environmental etiologies. Some ASD cases are syndromic: associated with clinically defined patterns of somatic abnormalities and a neurobehavioral phenotype (e.g., Fragile X syndrome). Many cases, however, are idiopathic or non-syndromic. Such disorders present themselves during the early postnatal period when language, speech, and personality start to develop. ASDs manifest by deficits in social communication and interaction, restricted and repetitive patterns of behavior across multiple contexts, sensory abnormalities across multiple modalities and comorbidities, such as epilepsy among many others. ASDs are disorders of connectivity, as synaptic dysfunction is common to both syndromic and idiopathic forms. While multiple theories have been proposed, particularly in idiopathic ASDs, none address why certain brain areas (e.g., frontotemporal) appear more vulnerable than others or identify factors that may affect phenotypic specificity. In this hypothesis article, we identify possible routes leading to, and the consequences of, altered connectivity and review the evidence of central and peripheral synaptic dysfunction in ASDs. We postulate that phenotypic specificity could arise from aberrant experience-dependent plasticity mechanisms in frontal brain areas and peripheral sensory networks and propose why the vulnerability of these areas could be part of a model to unify preexisting pathophysiological theories.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaThe Neuroscientist
Brojčani podacivol. 27, br. 1, str. 10-29
p-ISSN1073-8584
e-ISSN1089-4098
DOIhttps://doi.org/10.1177/1073858420921378
URN:NBNurn:nbn:hr:105:570841
Datum objave publikacije2021-02
URL dokumentahttp://journals.sagepub.com/doi/10.1177/1073858420921378
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2021-03-29 10:31:42