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Antiviral Cytokine Response in Neuroinvasive and Non-Neuroinvasive West Nile Virus Infection
Viruses, 13 (2021), 2; 342. https://doi.org/10.3390/v13020342
Židovec-Lepej, Snježana; Vilibić-Čavlek, Tatjana; Barbić, Ljubo; Ilić, Maja; Savić, Vladimir; Tabain, Irena; Ferenc, Thomas; Grgić, Ivana; Gorenec, Lana; Bogdanić, Maja; Stevanović, Vladimir; Sabadi, Dario; Perić, Ljiljana; Potočnik-Hunjadi, Tanja; Dvorski, Elizabeta; Butigan, Tamara; Capak, Krunoslav; Listes, Eddy; Savini, Giovanni Više autora...

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Židovec Lepej, S., Vilibić Čavlek, T., Barbić, Lj., Ilić, M., Savić, V., Tabain, I. ... Savini, G. (2021). Antiviral Cytokine Response in Neuroinvasive and Non-Neuroinvasive West Nile Virus Infection. Viruses, 13. (2). doi: 10.3390/v13020342

Židovec Lepej, Snježana, et al. "Antiviral Cytokine Response in Neuroinvasive and Non-Neuroinvasive West Nile Virus Infection." Viruses, vol. 13, br. 2, 2021. https://doi.org/10.3390/v13020342

Židovec Lepej, Snježana, Tatjana Vilibić Čavlek, Ljubo Barbić, Maja Ilić, Vladimir Savić, Irena Tabain, Thomas Ferenc, et al. "Antiviral Cytokine Response in Neuroinvasive and Non-Neuroinvasive West Nile Virus Infection." Viruses 13, br. 2 (2021). https://doi.org/10.3390/v13020342

Židovec Lepej, S., et al. (2021) 'Antiviral Cytokine Response in Neuroinvasive and Non-Neuroinvasive West Nile Virus Infection', Viruses, 13(2). doi: 10.3390/v13020342

Židovec Lepej S, Vilibić Čavlek T, Barbić Lj, Ilić M, Savić V, Tabain I, i sur.. Antiviral Cytokine Response in Neuroinvasive and Non-Neuroinvasive West Nile Virus Infection. Viruses [Internet]. 02.2021. [pristupljeno 08.10.2024.];13(2). doi: 10.3390/v13020342

S. Židovec Lepej, et al., "Antiviral Cytokine Response in Neuroinvasive and Non-Neuroinvasive West Nile Virus Infection", Viruses, vol. 13, br. 2, Veljača 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:048421. [Citirano: 08.10.2024.]

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Naslov (engleski)Antiviral Cytokine Response in Neuroinvasive and Non-Neuroinvasive West Nile Virus Infection
AutorSnježana Židovec-Lepej
AutorTatjana Vilibić-Čavlek
AutorLjubo Barbić
AutorMaja Ilić
AutorVladimir Savić
AutorIrena Tabain
AutorThomas Ferenc
AutorIvana Grgić
AutorLana Gorenec
AutorMaja Bogdanić
AutorVladimir Stevanović
AutorDario Sabadi
AutorLjiljana Perić
AutorTanja Potočnik-Hunjadi
AutorElizabeta Dvorski
AutorTamara Butigan
AutorKrunoslav Capak
AutorEddy Listes
AutorGiovanni Savini
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU MIKROBIOLOGIJU I PARAZITOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Medicinska mikrobiologija
Sažetak (engleski)
Data on the immune response to West Nile virus (WNV) are limited. We analyzed the antiviral cytokine response in serum and cerebrospinal fluid (CSF) samples of patients with WNV fever and WNV neuroinvasive disease using a multiplex bead-based assay for the simultaneous quantification of 13 human cytokines. The panel included cytokines associated with innate and early pro-inflammatory immune responses (TNF-α/IL-6), Th1 (IL-2/IFN-γ), Th2 (IL-4/IL-5/IL-9/IL-13), Th17 immune response (IL-17A/IL-17F/IL-21/IL-22) and the key anti-inflammatory cytokine IL-10. Elevated levels of IFN-γ were detected in 71.7% of CSF and 22.7% of serum samples (p = 0.003). Expression of IL-2/IL-4/TNF-α and Th1 17 cytokines (IL-17A/IL-17F/IL-21) was detected in the serum but not in the CSF (except one positive CSF sample for IL-17F/IL-4). While IL-6 levels were markedly higher in the CSF compared to serum (CSF median 2036.71, IQR 213.82–6190.50; serum median 24.48, IQR 11.93–49.81; p < 0.001), no difference in the IL-13/IL-9/IL-10/IFN-γ/IL-22 levels in serum/CSF was found. In conclusion, increased concentrations of the key cytokines associated with innate and early acute phase responses (IL-6) and Th1 type immune responses (IFN-γ) were found in the CNS of patients with WNV infection. In contrast, expression of the key T-cell growth factor IL-2, Th17 cytokines, a Th2 cytokine IL-4 and the proinflammatory cytokine TNF-α appear to be concentrated mainly in the periphery.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaViruses
Brojčani podacivol. 13, br. 2, 342
e-ISSN1999-4915
DOIhttps://doi.org/10.3390/v13020342
URN:NBNurn:nbn:hr:105:048421
Datum objave publikacije2021-02
URL dokumentahttps://www.mdpi.com/1999-4915/13/2/342
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2021-06-24 08:57:09