prikaz prve stranice dokumenta Expression Pattern of α-Tubulin, Inversin and Its Target Dishevelled-1 and Morphology of Primary Cilia in Normal Human Kidney Development and Diseases
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Expression Pattern of α-Tubulin, Inversin and Its Target Dishevelled-1 and Morphology of Primary Cilia in Normal Human Kidney Development and Diseases
International Journal of Molecular Sciences, 22 (2021), 7; 3500. https://doi.org/10.3390/ijms22073500
Šolić, Ivana; Racetin, Anita; Filipović, Natalija; Mardešić, Snježana; Bočina, Ivana; Galešić-Ljubanović, Danica; Glavina Durdov, Meri; Saraga-Babić, Mirna; Vukojević, Katarina

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Šolić, I., Racetin, A., Filipović, N., Mardešić, S., Bočina, I., Galešić Ljubanović, D. ... Vukojević, K. (2021). Expression Pattern of α-Tubulin, Inversin and Its Target Dishevelled-1 and Morphology of Primary Cilia in Normal Human Kidney Development and Diseases. International Journal of Molecular Sciences, 22. (7). doi: 10.3390/ijms22073500

Šolić, Ivana, et al. "Expression Pattern of α-Tubulin, Inversin and Its Target Dishevelled-1 and Morphology of Primary Cilia in Normal Human Kidney Development and Diseases." International Journal of Molecular Sciences, vol. 22, br. 7, 2021. https://doi.org/10.3390/ijms22073500

Šolić, Ivana, Anita Racetin, Natalija Filipović, Snježana Mardešić, Ivana Bočina, Danica Galešić Ljubanović, Meri Glavina Durdov, Mirna Saraga Babić i Katarina Vukojević. "Expression Pattern of α-Tubulin, Inversin and Its Target Dishevelled-1 and Morphology of Primary Cilia in Normal Human Kidney Development and Diseases." International Journal of Molecular Sciences 22, br. 7 (2021). https://doi.org/10.3390/ijms22073500

Šolić, I., et al. (2021) 'Expression Pattern of α-Tubulin, Inversin and Its Target Dishevelled-1 and Morphology of Primary Cilia in Normal Human Kidney Development and Diseases', International Journal of Molecular Sciences, 22(7). doi: 10.3390/ijms22073500

Šolić I, Racetin A, Filipović N, Mardešić S, Bočina I, Galešić Ljubanović D, i sur.. Expression Pattern of α-Tubulin, Inversin and Its Target Dishevelled-1 and Morphology of Primary Cilia in Normal Human Kidney Development and Diseases. International Journal of Molecular Sciences [Internet]. 28.03.2021. [pristupljeno 08.10.2024.];22(7). doi: 10.3390/ijms22073500

I. Šolić, et al., "Expression Pattern of α-Tubulin, Inversin and Its Target Dishevelled-1 and Morphology of Primary Cilia in Normal Human Kidney Development and Diseases", International Journal of Molecular Sciences, vol. 22, br. 7, Ožujak 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:753973. [Citirano: 08.10.2024.]

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Naslov (engleski)Expression Pattern of α-Tubulin, Inversin and Its Target Dishevelled-1 and Morphology of Primary Cilia in Normal Human Kidney Development and Diseases
AutorIvana Šolić
AutorAnita Racetin
AutorNatalija Filipović
AutorSnježana Mardešić
AutorIvana Bočina
AutorDanica Galešić-Ljubanović
AutorMeri Glavina Durdov
AutorMirna Saraga-Babić
AutorKatarina Vukojević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PATOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Sažetak (engleski)
The spatiotemporal expression of α-tubulin, inversin and dishevelled-1 (DVL-1) proteins associated with the Wnt-signaling pathway, and primary cilia morphology were analyzed in developing kidneys (14th–38th developmental weeks), healthy postnatal (1.5- and 7-years old) and pathologically changed human kidneys, including multicystic dysplastic kidneys (MCDK), focal segmental glomerulosclerosis (FSGS) and nephrotic syndrome of the Finnish type (CNF). The analysis was performed by double immunofluorescence, electron microscopy, semiquantitative and statistical methods. Cytoplasmic co-expression of α-tubulin, inversin and DVL-1 was observed in the proximal convoluted tubules (pct), distal convoluted tubules (dct) and glomeruli (g) of analyzed tissues. During kidney development, the overall expression of α-tubulin, inversin and DVL-1 decreased, while in the postnatal period slightly increased. The highest expressions of α-tubulin and inversin characterized dct and g, while high DVL-1 characterized pct. α-tubulin, inversin and DVL-1 expression pattern in MCDK, FSGS and CNF kidneys significantly differed from the healthy control. Compared to healthy kidneys, pathologically changed kidneys had dysmorphic primary cilia. Different expression dynamics of α-tubulin, inversin and DVL-1 during kidney development could indicate that switch between the canonical and noncanonical Wnt-signaling is essential for normal kidney morphogenesis. In contrast, their disturbed expression in pathological kidneys might be associated with abnormal primary cilia, leading to chronic kidney diseases.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 22, br. 7, 3500
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms22073500
URN:NBNurn:nbn:hr:105:753973
Datum objave publikacije2021-03-28
URL dokumentahttps://www.mdpi.com/1422-0067/22/7/3500
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2021-11-02 11:48:17