Parvovirus B19 in Croatia: A Large-Scale Seroprevalence Study

Znanstveni rad - Izvorni znanstveni rad

• Autor: Tatjana Vilibić-Čavlek
• Autor: Irena Tabain
• Autor: Branko Kolarić
• Autor: Klara Mihulja
• Autor: Lana Blažević
• Autor: Maja Bogdanić
• Autor: Dan Navolan
• Autor: Nataša Beader
• Autor: Anna Mrzljak
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA INTERNU MEDICINU)
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA MEDICINSKU MIKROBIOLOGIJU I PARAZITOLOGIJU)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Interna medicina
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Medicinska mikrobiologija

Sažetak (engleski)

Background and Objectives: Seroepidemiological studies indicate that parvovirus B19 circulates in all areas of the world, although with some differences. The aim of this study is to analyze the seroprevalence of parvovirus B19 in the Croatian population. Materials and Methods: From 2010 to 2021, 1538 serum samples from different populations were tested for the presence of parvovirus B19 IgM/IgG antibodies. Serological tests were performed using a commercial enzyme-linked immunosorbent assay. Results: IgG antibodies were detected in 986/64.1% of participants with differences (p < 0.001) among the following population groups: 42.4% of children and adolescents, 67.1% of the adult general population, 66.7% of hemodialysis patients, and 65.6% of liver transplant recipients. Seroprevalence increased with age, from 30.0% in the 6 months–9 years age group to 69.0% in the 40–49 years age group, and remained stable thereafter (68.8–73.3%). There was no difference in the seropositivity among males (66.1%) and females (63.1%), as well as the place of residence (suburban/rural 63.9%, urban 64.1%). IgM antibodies (current/recent infection) were found in 61/4.0% of participants with the highest seropositivity in the youngest age group (11.1%). In pregnant women, seroprevalence was higher in women with an unfavorable obstetric history compared with a normal pregnancy (IgG 71.0% vs. 62.6%; IgM 6.5% vs. 2.4%), but these differences were not significant. Logistic regression showed that the adult population had almost three times higher risk of IgG seropositivity compared to children/adolescents (general population OR = 2.777, 95% CI = 2.023–3.812; hemodialysis patients OR = 2.586, 95% CI = 1.531–4.367; and transplant patients OR = 2.717, 95% CI = 1.604–4.603). A one-year increase in age increased the risk of IgG seroprevalence (OR = 1.017; 95% CI = 1.011–1.022). Conclusions: Older age was the main risk factor for IgG seropositivity. Hemodialysis and organ transplantation seem unrelated to the increased parvovirus B19 seroprevalence. The role of parvovirus B19 in the etiology of TORCH infections needs to be studied further.

• Ključne riječi (engleski): Adolescent; Adult; Aged; Antibodies, Viral; Child; Child, Preschool; Croatia / epidemiology; Female; Humans; Immunoglobulin M; Infant; Male; Middle Aged; Parvoviridae Infections* / epidemiology; Parvovirus B19, Human*; Pregnancy; Seroepidemiologic Studies
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Medicina
• Brojčani podaci: vol. 57, br. 11, 1279
• p-ISSN: 1010-660X
• e-ISSN: 1648-9144
• DOI: https://doi.org/10.3390/medicina57111279
• URN:NBN: urn:nbn:hr:105:711297
• Datum objave publikacije: 2021-11-21
• Projekt: Šifra: IP-2020-02-7407; Naziv (hrvatski): Emergentni i zapostavljeni hepatotropni virusi nakon transplantacije solidnih organa i krvotvornih matičnih stanica; Naziv (engleski): Emerging and neglected hepatotropic viruses after solid organ and hematopoetic stem cell transplantation; Kratica: HepViroTransplant; Voditelj: Anna Mrzljak; Pravna nadležnost: Hrvatska; Financijer: HRZZ; Linija financiranja: IP
• URL dokumenta: https://www.mdpi.com/1648-9144/57/11/1279
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2022-03-01 09:09:08