prikaz prve stranice dokumenta Persistence and Severity of Cutaneous Manifestations in IgA Vasculitis Is Associated with Development of IgA Vasculitis Nephritis in Children
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Persistence and Severity of Cutaneous Manifestations in IgA Vasculitis Is Associated with Development of IgA Vasculitis Nephritis in Children
Dermatology, 238 (2022), 2; 340-346. https://doi.org/10.1159/000516765
Šestan, Mario; Srsen, Sasa; Kifer, Nastasia; Sapina, Matej; Batnozic Varga, Mateja; Ovuka, Aleksandar; Held, Martina; Kozmar, Ana; Frković, Marijan; Laskarin, Gordana; Gagro, Alenka; Jelušić, Marija

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Šestan, M., Srsen, S., Kifer, N., Sapina, M., Batnozic Varga, M., Ovuka, A. ... Jelušić, M. (2022). Persistence and Severity of Cutaneous Manifestations in IgA Vasculitis Is Associated with Development of IgA Vasculitis Nephritis in Children. Dermatology, 238. (2), 340-346. doi: 10.1159/000516765

Šestan, Mario, et al. "Persistence and Severity of Cutaneous Manifestations in IgA Vasculitis Is Associated with Development of IgA Vasculitis Nephritis in Children." Dermatology, vol. 238, br. 2, 2022, str. 340-346. https://doi.org/10.1159/000516765

Šestan, Mario, Sasa Srsen, Nastasia Kifer, Matej Sapina, Mateja Batnozic Varga, Aleksandar Ovuka, Martina Held, et al. "Persistence and Severity of Cutaneous Manifestations in IgA Vasculitis Is Associated with Development of IgA Vasculitis Nephritis in Children." Dermatology 238, br. 2 (2022): 340-346. https://doi.org/10.1159/000516765

Šestan, M., et al. (2022) 'Persistence and Severity of Cutaneous Manifestations in IgA Vasculitis Is Associated with Development of IgA Vasculitis Nephritis in Children', Dermatology, 238(2), str. 340-346. doi: 10.1159/000516765

Šestan M, Srsen S, Kifer N, Sapina M, Batnozic Varga M, Ovuka A, i sur.. Persistence and Severity of Cutaneous Manifestations in IgA Vasculitis Is Associated with Development of IgA Vasculitis Nephritis in Children. Dermatology [Internet]. 2022. [pristupljeno 01.12.2024.];238(2):340-346. doi: 10.1159/000516765

M. Šestan, et al., "Persistence and Severity of Cutaneous Manifestations in IgA Vasculitis Is Associated with Development of IgA Vasculitis Nephritis in Children", Dermatology, vol. 238, br. 2, str. 340-346, 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:464330. [Citirano: 01.12.2024.]

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Podaci o radu
Naslov (engleski)Persistence and Severity of Cutaneous Manifestations in IgA Vasculitis Is Associated with Development of IgA Vasculitis Nephritis in Children
AutorMario Šestan
AutorSasa Srsen
AutorNastasia Kifer
AutorMatej Sapina
AutorMateja Batnozic Varga
AutorAleksandar Ovuka
AutorMartina Held
AutorAna Kozmar
AutorMarijan Frković
AutorGordana Laskarin
AutorAlenka Gagro
AutorMarija Jelušić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PEDIJATRIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Pedijatrija
Sažetak (engleski)
Background/Objective: The purpose of this study was to evaluate the prevalence and severity of skin involvement in children with IgA vasculitis (IgAV) and its relationship with clinical and biochemical parameters and the risk of developing IgA vasculitis nephritis (IgAVN), the only cause of long-term morbidity and the main prognostic factor in IgAV patients. ----- Methods: This national multicenter retrospective study included 611 patients under the age of 18 years with IgAV referred to five Croatian tertiary hospitals between 2009 and 2019. Patient data were collected from a database with systematic analysis of IgAV patients in the Croatian population. ----- Results: Among the 611 children, 205 (33.55%) had purpura on the lower extremities, in 207 (33.88%) the rash extended on the trunk, in 149 (24.39%) it extended to the upper extremities, in 32 (5.24%) the rash was generalized, while 15 (2.47%) had the most severe skin symptoms: bullae, ulcerations, and necroses. IgAVN developed in 130 (21.28%) and persistent IgAVN (present for >3 months) in 48 (7.86%) children. Multivariate logistic regression found that presence of ulcerations and necroses (OR 3.20 [95% CI 1.03–9.91]), persistent purpura (OR 2.89 [95% CI 1.71–4.88]), and higher age (OR 1.16 [95% CI 1.09–1.23]) were significant predictors of IgAVN, whereas persistent purpura (OR 20.11 [95% CI 1.09–372.52]), male sex (OR 3.32 [95% CI 1.13–9.80]), and higher age (OR 1.15 [95% CI 1.00–1.30]) were predictors of persistent IgAVN. Among the laboratory parameters, higher serum urea (OR 1.43 [95% CI 1.03–2.00]) and reduction in activated partial thromboplastin time (OR 0.83 [95% CI 0.74–0.93]) were shown to have a significant impact on increasing the risk of persistent IgAVN. ----- Conclusion: With increasing severity and duration of cutaneous manifestations in IgAV, the risk of developing IgAVN increases, making the prognosis worse, with a greater likelihood to need more aggressive treatment.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeNije recenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaDermatology
Brojčani podacivol. 238, br. 2, str. 340-346
p-ISSN1018-8665
e-ISSN1421-9832
DOIhttps://doi.org/10.1159/000516765
URN:NBNurn:nbn:hr:105:464330
Datum objave publikacije2022
URL dokumentahttps://www.karger.com/Article/FullText/516765
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Datum isteka embarga: 2023-04-01
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-06-27 07:59:02