prikaz prve stranice dokumenta The Effect of Acute Oral Galactose Administration on the Redox System of the Rat Small Intestine
  Preuzmi
PDF 4.49 MB
Znanstveni rad - Izvorni znanstveni rad
The Effect of Acute Oral Galactose Administration on the Redox System of the Rat Small Intestine
Antioxidants, 11 (2021), 1; 37. https://doi.org/10.3390/antiox11010037
Homolak, Jan; Babić Perhoč, Ana; Knezović, Ana; Osmanović Barilar, Jelena; Virag, Davor; Joja, Mihovil; Šalković-Petrišić, Melita

Citirajte ovaj rad

Homolak, J., Babić Perhoč, A., Knezović, A., Osmanović Barilar, J., Virag, D., Joja, M. i Šalković Petrišić, M. (2021). The Effect of Acute Oral Galactose Administration on the Redox System of the Rat Small Intestine. Antioxidants, 11. (1). doi: 10.3390/antiox11010037

Homolak, Jan, et al. "The Effect of Acute Oral Galactose Administration on the Redox System of the Rat Small Intestine." Antioxidants, vol. 11, br. 1, 2021. https://doi.org/10.3390/antiox11010037

Homolak, Jan, Ana Babić Perhoč, Ana Knezović, Jelena Osmanović Barilar, Davor Virag, Mihovil Joja i Melita Šalković Petrišić. "The Effect of Acute Oral Galactose Administration on the Redox System of the Rat Small Intestine." Antioxidants 11, br. 1 (2021). https://doi.org/10.3390/antiox11010037

Homolak, J., et al. (2021) 'The Effect of Acute Oral Galactose Administration on the Redox System of the Rat Small Intestine', Antioxidants, 11(1). doi: 10.3390/antiox11010037

Homolak J, Babić Perhoč A, Knezović A, Osmanović Barilar J, Virag D, Joja M, i sur.. The Effect of Acute Oral Galactose Administration on the Redox System of the Rat Small Intestine. Antioxidants [Internet]. 24.12.2021. [pristupljeno 13.10.2024.];11(1). doi: 10.3390/antiox11010037

J. Homolak, et al., "The Effect of Acute Oral Galactose Administration on the Redox System of the Rat Small Intestine", Antioxidants, vol. 11, br. 1, Prosinac 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:513183. [Citirano: 13.10.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:513183
Prijavite se u repozitorij kako biste mogli spremiti objekt u svoju listu.
Podaci o radu
Naslov (engleski)The Effect of Acute Oral Galactose Administration on the Redox System of the Rat Small Intestine
AutorJan Homolak
AutorAna Babić Perhoč
AutorAna Knezović
AutorJelena Osmanović Barilar
AutorDavor Virag
AutorMihovil Joja
AutorMelita Šalković-Petrišić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Sažetak (engleski)
Galactose is a ubiquitous monosaccharide with important yet incompletely understood nutritive and physiological roles. Chronic parenteral d-galactose administration is used for modeling aging-related pathophysiological processes in rodents due to its ability to induce oxidative stress (OS). Conversely, chronic oral d-galactose administration prevents and alleviates cognitive decline in a rat model of sporadic Alzheimer’s disease, indicating that galactose may exert beneficial health effects by acting in the gut. The present aim was to explore the acute time-response of intestinal redox homeostasis following oral administration of d-galactose. Male Wistar rats were euthanized at baseline (n = 6), 30 (n = 6), 60 (n = 6), and 120 (n = 6) minutes following orogastric administration of d-galactose (200 mg/kg). The overall reductive capacity, lipid peroxidation, the concentration of low-molecular-weight thiols (LMWT) and protein sulfhydryls (SH), the activity of Mn and Cu/Zn superoxide dismutases (SOD), reduced and oxidized fractions of nicotinamide adenine dinucleotide phosphates (NADPH/NADP), and the hydrogen peroxide dissociation rate were analyzed in duodenum and ileum. Acute oral administration of d-galactose increased the activity of SODs and decreased intestinal lipid peroxidation and nucleophilic substrates (LMWT, SH, NADPH), indicating activation of peroxidative damage defense pathways. The redox system of the small intestine can acutely tolerate even high luminal concentrations of galactose (0.55 M), and oral galactose treatment is associated with a reduction rather than the increment of the intestinal OS. The ability of oral d-galactose to modulate intestinal OS should be further explored in the context of intestinal barrier maintenance, and beneficial cognitive effects associated with long-term administration of low doses of d-galactose.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaAntioxidants
Brojčani podacivol. 11, br. 1, 37
e-ISSN2076-3921
DOIhttps://doi.org/10.3390/antiox11010037
URN:NBNurn:nbn:hr:105:513183
Datum objave publikacije2021-12-24
ProjektŠifra: IP-2018-01-8938
Naziv (hrvatski): Mehanizmi nutrijentom posredovanih učinaka endogenog glukagonu sličnog peptida-1 na kognitivne i metaboličke poremećaje u eksperimentalnim modelima neurodegenerativnih bolesti
Kratica: NutrientGLP-1
Voditelj: Melita Šalković-Petrišić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
ProjektŠifra: KK.01.1.1.01.0007
Naziv (hrvatski): Eksperimentalna i klinička istraživanja hipoksijsko-ishemijskog oštećenja mozga u perinatalnoj i odrasloj dobi
Kratica: ZCI - NEURO
Voditelj: Miloš Judaš
Pravna nadležnost: eu
Financijer: EK
URL dokumentahttps://www.mdpi.com/2076-3921/11/1/37
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Dijeli pod istim uvjetima 4.0 međunarodna (CC BY-SA 4.0)
Datum i vrijeme pohrane2022-07-01 07:02:29