prikaz prve stranice dokumenta Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease
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Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease
International Journal of Molecular Sciences, 23 (2022), 1; 548. https://doi.org/10.3390/ijms23010548
Osmanović Barilar, Jelena; Knezović, Ana; Homolak, Jan; Babić Perhoč, Ana; Šalković-Petrišić, Melita

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Osmanović Barilar, J., Knezović, A., Homolak, J., Babić Perhoč, A. i Šalković Petrišić, M. (2022). Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease. International Journal of Molecular Sciences, 23. (1). doi: 10.3390/ijms23010548

Osmanović Barilar, Jelena, et al. "Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease." International Journal of Molecular Sciences, vol. 23, br. 1, 2022. https://doi.org/10.3390/ijms23010548

Osmanović Barilar, Jelena, Ana Knezović, Jan Homolak, Ana Babić Perhoč i Melita Šalković Petrišić. "Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease." International Journal of Molecular Sciences 23, br. 1 (2022). https://doi.org/10.3390/ijms23010548

Osmanović Barilar, J., et al. (2022) 'Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease', International Journal of Molecular Sciences, 23(1). doi: 10.3390/ijms23010548

Osmanović Barilar J, Knezović A, Homolak J, Babić Perhoč A, Šalković Petrišić M. Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease. International Journal of Molecular Sciences [Internet]. 04.01.2022. [pristupljeno 29.11.2024.];23(1). doi: 10.3390/ijms23010548

J. Osmanović Barilar, A. Knezović, J. Homolak, A. Babić Perhoč i M. Šalković Petrišić, "Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease", International Journal of Molecular Sciences, vol. 23, br. 1, Siječanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:792760. [Citirano: 29.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:792760
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Podaci o radu
Naslov (engleski)Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease
AutorJelena Osmanović Barilar
AutorAna Knezović
AutorJan Homolak
AutorAna Babić Perhoč
AutorMelita Šalković-Petrišić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Sažetak (engleski)
The incretin system is an emerging new field that might provide valuable contributions to the research of both the pathophysiology and therapeutic strategies in the treatment of diabetes, obesity, and neurodegenerative disorders. This study aimed to explore the roles of central glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) on cell metabolism and energy in the brain, as well as on the levels of these incretins, insulin, and glucose via inhibition of the central incretin receptors following intracerebroventricular administration of the respective antagonists in healthy rats and a streptozotocin-induced rat model of sporadic Alzheimer’s disease (sAD). Chemical ablation of the central GIP receptor (GIPR) or GLP-1 receptor (GLP-1R) in healthy and diseased animals indicated a region-dependent role of incretins in brain cell energy and metabolism and central incretin-dependent modulation of peripheral hormone secretion, markedly after GIPR inhibition, as well as a dysregulation of the GLP-1 system in experimental sAD.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 23, br. 1, 548
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms23010548
URN:NBNurn:nbn:hr:105:792760
Datum objave publikacije2022-01-04
URL dokumentahttps://www.mdpi.com/1422-0067/23/1/548
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-07-06 10:59:06