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Identifying the Common Genetic Basis of Antidepressant Response
Biological Psychiatry Global Open Science, 2 (2022), 2; 115-126. https://doi.org/10.1016/j.bpsgos.2021.07.008
(GSRD Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium) Pain, Oliver; Hodgson, Karen; Trubetskoy, Vassily; Ripke, Stephan; Marshe, Victoria S.; Adams, Mark J.; Byrne, Enda M.; Campos, Adrian I.; Carrillo-Roa, Tania; Cattaneo, Annamaria; Als, Thomas D.; Souery, Daniel; Dernovsek, Mojca Z.; Fabbri, Chiara; Hayward, Caroline; Henigsberg, Neven; Hauser, Joanna; Kennedy, James L.; Lenze, Eric J.; Lewis, Glyn; Müller, Daniel J.; Martin, Nicholas G.; Mulsant, Benoit H.; Mors, Ole; Perroud, Nader; Porteous, David J.; Rentería, Miguel E.; Reynolds III, Charles F.; Rietschel, Marcella; Uher, Rudolf; Wigmore, Eleanor M.; Maier, Wolfgang; Wray, Naomi R.; Aitchison, Katherine J.; Arolt, Volker; Baune, Bernhard T.; Biernacka, Joanna M.; Bondolfi, Guido; Domschke, Katharina; Kato, Masaki; Li, Qingqin S.; Liu, Yu-Li; Serretti, Alessandro; Tsai, Shih-Jen; Turecki, Gustavo; Weinshilboum, Richard; McIntosh, Andrew M.; Lewis, Cathryn M. Više autora...

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Pain, O., Hodgson, K., Trubetskoy, V., Ripke, S., Marshe, V. S., Adams, M. J. ... Lewis, C. M. (2022). Identifying the Common Genetic Basis of Antidepressant Response. Biological Psychiatry Global Open Science, 2. (2), 115-126. doi: 10.1016/j.bpsgos.2021.07.008

Pain, Oliver, et al. "Identifying the Common Genetic Basis of Antidepressant Response." Biological Psychiatry Global Open Science, vol. 2, br. 2, 2022, str. 115-126. https://doi.org/10.1016/j.bpsgos.2021.07.008

Pain, Oliver, Karen Hodgson, Vassily Trubetskoy, Stephan Ripke, Victoria S. Marshe, Mark J. Adams, Enda M. Byrne, et al. "Identifying the Common Genetic Basis of Antidepressant Response." Biological Psychiatry Global Open Science 2, br. 2 (2022): 115-126. https://doi.org/10.1016/j.bpsgos.2021.07.008

Pain, O., et al. (2022) 'Identifying the Common Genetic Basis of Antidepressant Response', Biological Psychiatry Global Open Science, 2(2), str. 115-126. doi: 10.1016/j.bpsgos.2021.07.008

Pain O, Hodgson K, Trubetskoy V, Ripke S, Marshe VS, Adams MJ, i sur.. Identifying the Common Genetic Basis of Antidepressant Response. Biological Psychiatry Global Open Science [Internet]. 04.2022. [pristupljeno 05.10.2024.];2(2):115-126. doi: 10.1016/j.bpsgos.2021.07.008

O. Pain, et al., "Identifying the Common Genetic Basis of Antidepressant Response", Biological Psychiatry Global Open Science, vol. 2, br. 2, str. 115-126, Travanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:085279. [Citirano: 05.10.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:085279
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Naslov (engleski)Identifying the Common Genetic Basis of Antidepressant Response
AutorOliver Pain
AutorKaren Hodgson
AutorVassily Trubetskoy
AutorStephan Ripke
AutorVictoria S. Marshe
AutorMark J. Adams
AutorEnda M. Byrne
AutorAdrian I. Campos
AutorTania Carrillo-Roa
AutorAnnamaria Cattaneo
AutorThomas D. Als
AutorDaniel Souery
AutorMojca Z. Dernovsek
AutorChiara Fabbri
AutorCaroline Hayward
AutorNeven Henigsberg
AutorJoanna Hauser
AutorJames L. Kennedy
AutorEric J. Lenze
AutorGlyn Lewis
AutorDaniel J. Müller
AutorNicholas G. Martin
AutorBenoit H. Mulsant
AutorOle Mors
AutorNader Perroud
AutorDavid J. Porteous
AutorMiguel E. Rentería
AutorCharles F. Reynolds III
AutorMarcella Rietschel
AutorRudolf Uher
AutorEleanor M. Wigmore
AutorWolfgang Maier
AutorNaomi R. Wray
AutorKatherine J. Aitchison
AutorVolker Arolt
AutorBernhard T. Baune
AutorJoanna M. Biernacka
AutorGuido Bondolfi
AutorKatharina Domschke
AutorMasaki Kato
AutorQingqin S. Li
AutorYu-Li Liu
AutorAlessandro Serretti
AutorShih-Jen Tsai
AutorGustavo Turecki
AutorRichard Weinshilboum
AutorAndrew M. McIntosh
AutorCathryn M. Lewis
KolaboracijaGSRD Consortium
KolaboracijaMajor Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PSIHIJATRIJU I PSIHOLOŠKU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Sažetak (engleski)
Background: Antidepressants are a first-line treatment for depression. However, only a third of individuals experience remission after the first treatment. Common genetic variation, in part, likely regulates antidepressant response, yet the success of previous genome-wide association studies has been limited by sample size. This study performs the largest genetic analysis of prospectively assessed antidepressant response in major depressive disorder to gain insight into the underlying biology and enable out-of-sample prediction. ----- Methods: Genome-wide analysis of remission (n remit = 1852, n nonremit = 3299) and percentage improvement (n = 5218) was performed. Single nucleotide polymorphism-based heritability was estimated using genome-wide complex trait analysis. Genetic covariance with eight mental health phenotypes was estimated using polygenic scores/AVENGEME. Out-of-sample prediction of antidepressant response polygenic scores was assessed. Gene-level association analysis was performed using MAGMA and transcriptome-wide association study. Tissue, pathway, and drug binding enrichment were estimated using MAGMA. ----- Results: Neither genome-wide association study identified genome-wide significant associations. Single nucleotide polymorphism-based heritability was significantly different from zero for remission (h 2 = 0.132, SE = 0.056) but not for percentage improvement (h 2 = -0.018, SE = 0.032). Better antidepressant response was negatively associated with genetic risk for schizophrenia and positively associated with genetic propensity for educational attainment. Leave-one-out validation of antidepressant response polygenic scores demonstrated significant evidence of out-of-sample prediction, though results varied in external cohorts. Gene-based analyses identified ETV4 and DHX8 as significantly associated with antidepressant response. Conclusions: This study demonstrates that antidepressant response is influenced by common genetic variation, has a genetic overlap schizophrenia and educational attainment, and provides a useful resource for future research. Larger sample sizes are required to attain the potential of genetics for understanding and predicting antidepressant response.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiological Psychiatry Global Open Science
Brojčani podacivol. 2, br. 2, str. 115-126
p-ISSN2667-1743
DOIhttps://doi.org/10.1016/j.bpsgos.2021.07.008
URN:NBNurn:nbn:hr:105:085279
Datum objave publikacije2022-04
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S2667174321000859
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-12-06 10:32:50