prikaz prve stranice dokumenta Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD
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Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD
Biomolecules, 12 (2022), 5; 736. https://doi.org/10.3390/biom12050736
Repovečki, Senka; Nedić Erjavec, Gordana; Uzun, Suzana; Tudor, Lucija; Nikolac Perković, Matea; Konjevod, Marcela; Kozumplik, Oliver; Švob Štrac, Dubravka; Kovačić Petrović, Zrnka; Mimica, Ninoslav; Pivac, Nela

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Repovečki, S., Nedić Erjavec, G., Uzun, S., Tudor, L., Nikolac Perković, M., Konjevod, M. ... Pivac, N. (2022). Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD. Biomolecules, 12. (5). doi: 10.3390/biom12050736

Repovečki, Senka, et al. "Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD." Biomolecules, vol. 12, br. 5, 2022. https://doi.org/10.3390/biom12050736

Repovečki, Senka, Gordana Nedić Erjavec, Suzana Uzun, Lucija Tudor, Matea Nikolac Perković, Marcela Konjevod, Oliver Kozumplik, et al. "Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD." Biomolecules 12, br. 5 (2022). https://doi.org/10.3390/biom12050736

Repovečki, S., et al. (2022) 'Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD', Biomolecules, 12(5). doi: 10.3390/biom12050736

Repovečki S, Nedić Erjavec G, Uzun S, Tudor L, Nikolac Perković M, Konjevod M, i sur.. Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD. Biomolecules [Internet]. 23.05.2022. [pristupljeno 29.11.2024.];12(5). doi: 10.3390/biom12050736

S. Repovečki, et al., "Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD", Biomolecules, vol. 12, br. 5, Svibanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:663190. [Citirano: 29.11.2024.]

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Podaci o radu
Naslov (engleski)Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD
AutorSenka Repovečki
AutorGordana Nedić Erjavec
AutorSuzana Uzun
AutorLucija Tudor
AutorMatea Nikolac Perković
AutorMarcela Konjevod
AutorOliver Kozumplik
AutorDubravka Švob Štrac
AutorZrnka Kovačić Petrović
AutorNinoslav Mimica
AutorNela Pivac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PSIHIJATRIJU I PSIHOLOŠKU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Sažetak (engleski)
Post-traumatic stress disorder (PTSD) is a trauma-related disorder. Platelet monoamine oxidase (MAO-B) is a peripheral biomarker associated with various symptoms in different psychopathologies, but its role in PTSD or different symptoms in PTSD is not clear. This study elucidated the association between platelet MAO-B activity and clinical symptoms occurring in PTSD. Platelet MAO-B activity was determined in 1053 male Caucasian subjects: 559 war veterans with PTSD (DSM-5 criteria), 62 combat exposed veterans who did not develop PTSD, and 432 non-combat exposed healthy controls. Clinical symptoms in PTSD were determined using CAPS and PANSS. Platelet MAO-B activity, controlled for the effect of smoking, was significantly increased in PTSD with severe versus mild and moderate traumatic symptoms, and was significantly decreased in PTSD subjects with severe versus mild positive, psychotic, and depressive symptoms. This finding was further confirmed with reduced platelet MAO-B activity in PTSD veterans with severe versus mild individual items of the PANSS-depressed, PANSS-psychotic, and PANSS-positive subscales. Altered platelet MAO-B activity, controlled for the possible confounders, was associated with the development and severity of different symptoms occurring in PTSD. These findings confirmed the role of platelet MAO-B activity as a peripheral marker of various psychopathological symptoms.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomolecules
Brojčani podacivol. 12, br. 5, 736
e-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom12050736
URN:NBNurn:nbn:hr:105:663190
Datum objave publikacije2022-05-23
ProjektŠifra: IP-2014-09-4289
Naziv (hrvatski): Genomski i glikanski biomarkeri PTSP-a
Naziv (engleski): Genomic and glycomic biomarkers for PTSD
Kratica: GlycoGenePTSD
Voditelj: Nela Pivac
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
URL dokumentahttps://www.mdpi.com/2218-273X/12/5/736
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-12-12 08:05:10