prikaz prve stranice dokumenta Gangliosidome of a Human Hippocampus in Temporal Lobe Epilepsy Resolved by High-Resolution Tandem Mass Spectrometry
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Gangliosidome of a Human Hippocampus in Temporal Lobe Epilepsy Resolved by High-Resolution Tandem Mass Spectrometry
Molecules, 27 (2022), 13; 4056. https://doi.org/10.3390/molecules27134056
Ica, Raluca; Mlinac-Jerković, Kristina; Ilić, Katarina; Sajko, Tomislav; Munteanu, Cristian V. A.; Zamfir, Alina D.; Kalanj-Bognar, Svjetlana

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Ica, R., Mlinac Jerković, K., Ilić, K., Sajko, T., Munteanu, C. V. A., Zamfir, A. D. i Kalanj Bognar, S. (2022). Gangliosidome of a Human Hippocampus in Temporal Lobe Epilepsy Resolved by High-Resolution Tandem Mass Spectrometry. Molecules, 27. (13). doi: 10.3390/molecules27134056

Ica, Raluca, et al. "Gangliosidome of a Human Hippocampus in Temporal Lobe Epilepsy Resolved by High-Resolution Tandem Mass Spectrometry." Molecules, vol. 27, br. 13, 2022. https://doi.org/10.3390/molecules27134056

Ica, Raluca, Kristina Mlinac Jerković, Katarina Ilić, Tomislav Sajko, Cristian V. A. Munteanu, Alina D. Zamfir i Svjetlana Kalanj Bognar. "Gangliosidome of a Human Hippocampus in Temporal Lobe Epilepsy Resolved by High-Resolution Tandem Mass Spectrometry." Molecules 27, br. 13 (2022). https://doi.org/10.3390/molecules27134056

Ica, R., et al. (2022) 'Gangliosidome of a Human Hippocampus in Temporal Lobe Epilepsy Resolved by High-Resolution Tandem Mass Spectrometry', Molecules, 27(13). doi: 10.3390/molecules27134056

Ica R, Mlinac Jerković K, Ilić K, Sajko T, Munteanu CVA, Zamfir AD, i sur.. Gangliosidome of a Human Hippocampus in Temporal Lobe Epilepsy Resolved by High-Resolution Tandem Mass Spectrometry. Molecules [Internet]. 23.06.2022. [pristupljeno 01.12.2024.];27(13). doi: 10.3390/molecules27134056

R. Ica, et al., "Gangliosidome of a Human Hippocampus in Temporal Lobe Epilepsy Resolved by High-Resolution Tandem Mass Spectrometry", Molecules, vol. 27, br. 13, Lipanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:696067. [Citirano: 01.12.2024.]

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Naslov (engleski)Gangliosidome of a Human Hippocampus in Temporal Lobe Epilepsy Resolved by High-Resolution Tandem Mass Spectrometry
AutorRaluca Ica
AutorKristina Mlinac-Jerković
AutorKatarina Ilić
AutorTomislav Sajko
AutorCristian V. A. Munteanu
AutorAlina D. Zamfir
AutorSvjetlana Kalanj-Bognar
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU KEMIJU, BIOKEMIJU I KLINIČKU KEMIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
In this study, we developed a high-resolution tandem mass spectrometry (HR MS) approach to assess presumed changes in gangliosidome of a human hippocampus affected by temporal lobe epilepsy (TLE) in comparison with a normal hippocampus. Gangliosides, membrane glycolipids, are particularly diverse and abundant in the human brain, and participate in ion transport and modulation of neuronal excitability. Changes in structural ganglioside pattern potentially linked to TLE molecular pathogenesis have not been explored in detail. Aiming to characterize TLE-specific gangliosidome, we analyzed the native gangliosides purified from a human hippocampal tissue sample affected by TLE and a control hippocampus using HR MS. Marked differences of ganglioside expression were shown in TLE vs. control, particularly with respect to the sialylation degree of components, discovered as a characteristic feature of TLE. Another major finding is the occurrence of tetrasialofucogangliosides in TLE and species modified by either O-acetylation or CH3COO−. Structural analysis by higher-energy collisional dissociation (HCD) MS/MS gave rise to fragmentation patterns implying that the GQ1b (d18:1/18:0) isomer is specifically associated with TLE. Further investigation in a larger sample is needed in order to confirm the discovery of ganglioside structures specifically expressed in human TLE and to provide information on the probable role of gangliosides in the molecular events underlying seizures.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMolecules
Brojčani podacivol. 27, br. 13, 4056
e-ISSN1420-3049
DOIhttps://doi.org/10.3390/molecules27134056
URN:NBNurn:nbn:hr:105:696067
Datum objave publikacije2022-06-23
URL dokumentahttps://www.mdpi.com/1420-3049/27/13/4056
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-04-19 10:37:09