TGF Beta as a Prognostic Biomarker of COVID-19 Severity in Patients with NAFLD: A Prospective Case – Control Study

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• Autor: Frano Šušak
• Autor: Nina Vrsaljko
• Autor: Adriana Vince
• Autor: Neven Papić
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA INFEKTOLOGIJU)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Infektologija

Sažetak (engleski)

Non-alcoholic fatty liver disease (NAFLD), the leading cause of chronic liver disease in Western countries, has been identified as a possible risk factor for COVID-19 severity. However, the immunological mechanisms by which NAFLD exacerbates COVID-19 remain unknown. Transforming growth factor-beta 1 (TGF-β1) has an important immunomodulatory and pro-fibrotic role, which has already been described in NAFLD. However, the role of TGF-β1 in COVID-19 remains unclear, and could also be the pathophysiology link between these two conditions. The aim of this case–control study was to analyze the expression of TGF-β1 in COVID-19 patients depending on the presence of NAFLD and COVID-19 severity. Serum TGF-β1 concentrations were measured in 60 hospitalized COVID-19 patients (30 with NAFLD). NAFLD was associated with higher serum TGF-β1 concentrations that increased with disease severity. Admission TGF-β1 concentrations showed good discriminative accuracy in predicting the development of critical disease and COVID-19 complications (need for advanced respiratory support, ICU admission, time to recovery, development of nosocomial infections and mortality). In conclusion, TGF-β1 could be an efficient biomarker for predicting COVID-19 severity and adverse outcomes in patients with NAFLD.

• Ključne riječi (engleski): COVID-19; NAFLD; SARS-CoV-2; TGF-β1; cytokines; inflammation; non-alcoholic fatty liver disease
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Microorganisms
• Brojčani podaci: vol. 11, br. 6, 1571
• e-ISSN: 2076-2607
• DOI: https://doi.org/10.3390/microorganisms11061571
• URN:NBN: urn:nbn:hr:105:219307
• Datum objave publikacije: 2023-06-13
• Projekt: Šifra: UIP-2019-04-7194; Naziv (hrvatski): Uloga imunih semaforina u nealkoholnoj masnoj bolesti jetre i sepsi; Naziv (engleski): The role of immune semaphorins in NAFLD and sepsis; Kratica: SepsisFAT; Voditelj: Neven Papić; Pravna nadležnost: Hrvatska; Financijer: HRZZ; Linija financiranja: UIP
• URL dokumenta: https://www.mdpi.com/2076-2607/11/6/1571
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2023-09-18 09:29:00