prikaz prve stranice dokumenta D‐galactose might mediate some of the skeletal muscle hypertrophy‐promoting effects of milk—A nutrient to consider for sarcopenia?
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D‐galactose might mediate some of the skeletal muscle hypertrophy‐promoting effects of milk—A nutrient to consider for sarcopenia?
BioEssays, 46 (2023), 2; e2300061. https://doi.org/10.1002/bies.202300061
Homolak, Jan; Babić Perhoč, Ana; Virag, Davor; Knezović, Ana; Osmanović Barilar, Jelena; Šalković‐Petrišić, Melita

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Homolak, J., Babić Perhoč, A., Virag, D., Knezović, A., Osmanović Barilar, J. i Šalković‐Petrišić, M. (2023). D‐galactose might mediate some of the skeletal muscle hypertrophy‐promoting effects of milk—A nutrient to consider for sarcopenia?. BioEssays, 46. (2). doi: 10.1002/bies.202300061

Homolak, Jan, et al. "D‐galactose might mediate some of the skeletal muscle hypertrophy‐promoting effects of milk—A nutrient to consider for sarcopenia?." BioEssays, vol. 46, br. 2, 2023. https://doi.org/10.1002/bies.202300061

Homolak, Jan, Ana Babić Perhoč, Davor Virag, Ana Knezović, Jelena Osmanović Barilar i Melita Šalković‐Petrišić. "D‐galactose might mediate some of the skeletal muscle hypertrophy‐promoting effects of milk—A nutrient to consider for sarcopenia?." BioEssays 46, br. 2 (2023). https://doi.org/10.1002/bies.202300061

Homolak, J., et al. (2023) 'D‐galactose might mediate some of the skeletal muscle hypertrophy‐promoting effects of milk—A nutrient to consider for sarcopenia?', BioEssays, 46(2). doi: 10.1002/bies.202300061

Homolak J, Babić Perhoč A, Virag D, Knezović A, Osmanović Barilar J, Šalković‐Petrišić M. D‐galactose might mediate some of the skeletal muscle hypertrophy‐promoting effects of milk—A nutrient to consider for sarcopenia?. BioEssays [Internet]. 06.12.2023. [pristupljeno 13.10.2024.];46(2). doi: 10.1002/bies.202300061

J. Homolak, A. Babić Perhoč, D. Virag, A. Knezović, J. Osmanović Barilar i M. Šalković‐Petrišić, "D‐galactose might mediate some of the skeletal muscle hypertrophy‐promoting effects of milk—A nutrient to consider for sarcopenia?", BioEssays, vol. 46, br. 2, Prosinac 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:763837. [Citirano: 13.10.2024.]

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Naslov (engleski)D‐galactose might mediate some of the skeletal muscle hypertrophy‐promoting effects of milk—A nutrient to consider for sarcopenia?
AutorJan Homolak
AutorAna Babić Perhoč
AutorDavor Virag
AutorAna Knezović
AutorJelena Osmanović Barilar
AutorMelita Šalković‐Petrišić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Sažetak (engleski)
Sarcopenia is a process of progressive aging‐associated loss of skeletal muscle mass (SMM) recognized as a serious global health issue contributing to frailty and increased all‐cause mortality. Exercise and nutritional interventions (particularly intake of dairy products and milk) demonstrate good efficacy, safety, and broad applicability. Here, we propose that at least some of the well‐documented favorable effects of milk and milk‐derived protein supplements on SMM might be mediated by D‐galactose, a monosaccharide present in large quantities in milk in the form of disaccharide lactose (milk sugar). We suggest that ingestion of dairy products results in exposure to D‐galactose in concentrations metabolized primarily via the Leloir pathway with the potential to (i) promote anabolic signaling via maintenance of growth factor (e.g., insulin‐like growth factor 1 [IGF‐1]) receptor mature glycosylation patterns; and (ii) provide extracellular (liver glycogen) and intracellular substrates for short (muscle glycolysis) and long‐term (muscle glycogen, intramyocellular lipids) energy availability. Additionally, D‐galactose might optimize the metabolic function of skeletal muscles by increasing mitochondrial content and stimulating glucose and fatty acid utilization. The proposed potential of D‐galactose to promote the accretion of SMM is discussed in the context of its therapeutic potential in sarcopenia.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBioEssays
Brojčani podacivol. 46, br. 2, e2300061
p-ISSN0265-9247
e-ISSN1521-1878
DOIhttps://doi.org/10.1002/bies.202300061
URN:NBNurn:nbn:hr:105:763837
Datum objave publikacije2023-12-06
ProjektŠifra: IP-2018-01-8938
Naziv (hrvatski): Mehanizmi nutrijentom posredovanih učinaka endogenog glukagonu sličnog peptida-1 na kognitivne i metaboličke poremećaje u eksperimentalnim modelima neurodegenerativnih bolesti
Kratica: NutrientGLP-1
Voditelj: Melita Šalković-Petrišić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
ProjektŠifra: KK.01.1.1.01.0007
Naziv (engleski): Eksperimentalna i klinička istraživanja hipoksijsko-ishemijskog oštećenja mozga u perinatalnoj i odrasloj dobi
Voditelj: Ivica Kostović
Pravna nadležnost: eu
Financijer: EK
URL dokumentahttps://onlinelibrary.wiley.com/doi/10.1002/bies.202300061
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2024-03-07 11:57:50