Health-related quality of life and fatigue in patients with adrenal incidentaloma

Znanstveni rad - Izvorni znanstveni rad

• Autor: Darko Kaštelan
• Autor: Fedja Džubur
• Autor: Tina Dušek
• Autor: Tamara Poljičanin
• Autor: Željka Crnčević-Orlić
• Autor: Ivana Kraljević
• Autor: Mirsala Solak
• Autor: Tanja Benčević
• Autor: Izet Aganović
• Autor: Nikola Knežević
• Autor: Željko Kaštelan
• Autor: Mirko Koršić
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti

Sažetak (engleski)

The objective of the present study was to examine several dimensions of quality of life (QoL) and fatigue in patients with adrenal incidentaloma. This was a case-control study designed to analyze patient outcomes using three validated generic QoL questionnaires, EQ-5D, SF-36, and MFI-20, the results of which were compared to those obtained for age- and sex-matched controls. The study population comprised 139 consecutive patients with nonfunctioning adrenal masses (104 females, 35 males; age 59.1 ± 10.8) and 139 age- and sex-matched controls. Reduced QoL was found in patients with adrenal incidentaloma as compared to controls. Dimensions of QoL that were notably affected included mobility (P = 0.03), performance of usual activities (P = 0.002), and anxiety/depression (P = 0.04) as evaluated using the EQ-5D; physical functioning (P < 0.001), physical role (P < 0.001), general health (P < 0.001), vitality (P = 0.001), social functioning (P = 0.001), and emotional role (P < 0.001) as evaluated using the SF-36; and physical fatigue (P = 0.04) as assessed using the MFI-20 questionnaire. In addition, perceived health on a visual analogue scale was also significantly lower in patients than in controls (64.8 ± 19.2 vs. 77.1 ± 15.1; P < 0.001). Patients with adrenal incidentaloma reported reduced QoL and a higher level of physical fatigue compared to age- and sex-matched controls. This subject will benefit from further studies comparing QoL outcomes of laparoscopic adrenalectomy versus no treatment in patients with adrenal incidentaloma.

• Ključne riječi (engleski): Activities of Daily Living/psychology; Adrenal Gland Neoplasms/complications; Adrenal Gland Neoplasms/physiopathology; Adrenal Gland Neoplasms/psychology; Aged; Case-Control Studies; Depression/epidemiology; Depression/etiology; Depression/physiopathology; Fatigue/epidemiology; Fatigue/etiology; Fatigue/physiopathology; Female; Humans; Male; Middle Aged; Prevalence; Quality of Life/psychology; Questionnaires
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Završna verzija rukopisa prihvaćena za objavljivanje (postprint)
• Naslov časopisa: Endocrine
• Brojčani podaci: vol. 40, br. 1, str. 84-89
• p-ISSN: 1355-008X
• DOI: https://doi.org/10.1007/s12020-011-9456-3
• URN:NBN: urn:nbn:hr:105:698786
• Datum objave publikacije: 2011-08
• URL dokumenta: https://doi.org/10.1007/s12020-011-9456-3
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2024-03-27 19:27:42