Relationship between adiponectin level, insulin sensitivity, and metabolic syndrome in type 1 diabetic patients

Znanstveni rad - Izvorni znanstveni rad

• Autor: Kristina Blaslov
• Autor: Tomislav Bulum
• Autor: Karin Zibar
• Autor: Lea Duvnjak
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti

Sažetak (engleski)

Objective. Adiponectin is known to be decreased in insulin resistance (IR) and metabolic syndrome (MS) which can be present
in patients with type 1 diabetes mellitus (T1DM). The aim of this study was to evaluate the relationship between adiponectin
level, MS, and insulin sensitivity in T1DM. ----- Research Design and Methods. The study included 77 T1DM patients divided into
two groups based on the total plasma adiponectin median value. Insulin sensitivity was calculated with the equation for eGDR,
and MS was defined according to International Diabetes Federation criteria. ----- Results. Patients with higher adiponectin
level (n = 39) had significantly lower waist circumference (P < 0.002), fasting venous glucose levels (P < 0.001),
higher HDL3-cholesterol (P = 0.011), and eGDR (P = 0.003) in comparison to the group with lower adiponectin who showed
higher prevalence of MS (P = 0.045). eGDR increased for 1.09 mg/kg(-1) min(-1) by each increase of 1  µ g/mL total fasting
plasma adiponectin (P = 0.003). In the logistic regression model, adiponectin was inversely associated with the presence
of MS (P = 0.014). ----- Conclusion. Higher adiponectin concentration is associated with lower prevalence of MS in T1DM. Whether
higher adiponectin concentration has a protective role in the development of the MS in T1DM needs to be clarified in future
follow-up studies.

• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: International Journal of Endocrinology
• Brojčani podaci: vol. 2013
• p-ISSN: 1687-8337
• DOI: https://doi.org/10.1155/2013/535906
• URN:NBN: urn:nbn:hr:105:769372
• Datum objave publikacije: 2013
• URL dokumenta: https://doi.org/10.1155/2013/535906
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2024-03-27 19:59:52