prikaz prve stranice dokumenta Oxidative stress impact on growth hormone secretion in the eye
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Oxidative stress impact on growth hormone secretion in the eye
Croatian Medical Journal, 56 (2015), 4; 326-333. https://doi.org/10.3325/cmj.2015.56.326
Šarić, Borna; Brzović Šarić, Vlatka; Barberić, Monika; Predović, Jurica; Rumenjak, Vlatko; Cerovski, Branimir

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Šarić, B., Brzović Šarić, V., Barberić, M., Predović, J., Rumenjak, V. i Cerovski, B. (2015). Oxidative stress impact on growth hormone secretion in the eye. Croatian Medical Journal, 56. (4), 326-333. doi: 10.3325/cmj.2015.56.326

Šarić, Borna, et al. "Oxidative stress impact on growth hormone secretion in the eye." Croatian Medical Journal, vol. 56, br. 4, 2015, str. 326-333. https://doi.org/10.3325/cmj.2015.56.326

Šarić, Borna, Vlatka Brzović Šarić, Monika Barberić, Jurica Predović, Vlatko Rumenjak i Branimir Cerovski. "Oxidative stress impact on growth hormone secretion in the eye." Croatian Medical Journal 56, br. 4 (2015): 326-333. https://doi.org/10.3325/cmj.2015.56.326

Šarić, B., et al. (2015) 'Oxidative stress impact on growth hormone secretion in the eye', Croatian Medical Journal, 56(4), str. 326-333. doi: 10.3325/cmj.2015.56.326

Šarić B, Brzović Šarić V, Barberić M, Predović J, Rumenjak V, Cerovski B. Oxidative stress impact on growth hormone secretion in the eye. Croatian Medical Journal [Internet]. 08.2015. [pristupljeno 12.07.2024.];56(4):326-333. doi: 10.3325/cmj.2015.56.326

B. Šarić, V. Brzović Šarić, M. Barberić, J. Predović, V. Rumenjak i B. Cerovski, "Oxidative stress impact on growth hormone secretion in the eye", Croatian Medical Journal, vol. 56, br. 4, str. 326-333, Kolovoz 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:725372. [Citirano: 12.07.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:725372
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Podaci o radu
Naslov (engleski)Oxidative stress impact on growth hormone secretion in the eye
AutorBorna Šarić
AutorVlatka Brzović Šarić
AutorMonika Barberić
AutorJurica Predović
AutorVlatko Rumenjak
AutorBranimir Cerovski
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
AIM: To evaluate the influence of oxidative stress on extrapituitary growth hormone (GH) secretion in the eye and to analyze the interdependence between eye and serum GH levels under normal and hypoxic conditions. ----- METHODS: Pars plana vitrectomy (PPV) was performed in 32 patients with developed proliferative diabetic retinopathy (PDR) and 49 non-diabetic controls, both of whom required this procedure as part of their regular treatment in the period from April 2013 to December 2014. During PPV, vitreous samples were taken and blood was simultaneously collected from the cubital vein. GH levels in serum and vitreous samples were measured by electrochemical luminescence assay. Oxidative stress was measured by enzyme-linked immunosorbent assay of advanced oxidation protein products (AOPP) and lipid hydroperoxide (LPO) in serum and vitreous. ----- RESULTS: Serum AOPP levels were significantly higher than vitreous levels in both groups (P<0.001 for each group) and LPO levels were significantly higher only in PDR group (P<0.001). There was a significant positive correlation between serum and vitreous LPO levels in PDR group (r=0.909; P<0.001). Serum GH levels were significantly higher than vitreous levels in both groups (P<0.001 for each group). Serum GH levels were significantly higher in PDR group than in controls (P=0.012). Vitreous GH values were slightly higher in PDR group, but the difference was not significant. ----- CONCLUSION: Our study confirms that GH production in the eye is autonomous and independent of oxidative stress or pituitary GH influence.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 56, br. 4, str. 326-333
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2015.56.326
URN:NBNurn:nbn:hr:105:725372
Datum objave publikacije2015-08
URL dokumentahttps://doi.org/10.3325/cmj.2015.56.326
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 08:27:22