Molecular mechanisms of Chlamydia trachomatis resistance to antimicrobial drugs

Znanstveni rad - Pregledni rad

• Autor: Tomislav Meštrović
• Autor: Sunčanica Ljubin-Sternak
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti

Sažetak (engleski)

Chlamydia trachomatis (C. trachomatis) is a leading cause of bacterial sexually transmitted infections in developed and undeveloped countries, and therefore a global public health issue. In an era of increasing bacterial resistance to antibiotics, resistance has been an exceedingly rare phenomenon in C. trachomatis; however, clinical treatment failures attributed to multidrug-resistant C. trachomatis strains have been described on several occasions. Cell culture systems using McCoy cells and subsequent immunofluorescent staining are still the most common methodology used for antimicrobial susceptibility testing, but the presence of resistance markers should be appraised by further genetic analysis. Azithromycin resistance of C. trachomatis is often a result of the mutations in the peptidyl transferase region of 23S rRNA genes, tetracycline resistance is usually linked to the presence of foreign genomic islands integrated in chlamydial chromosome, whereas a predominant mechanism of fluoroquinolone resistance is a point mutation in the gyrA quinolone-resistance-determining region. A nucleotide substitution in rpoB gene is responsible for rifampin resistance, and different mechanisms have been involved in the development of resistance to aminoglycosides, lincomycin and sulphonamide/trimethoprim combinations.

• Ključne riječi (engleski): Anti-Bacterial Agents/pharmacology; Chlamydia Infections/microbiology; Chlamydia trachomatis/drug effects; Chlamydia trachomatis/genetics; Drug Resistance, Bacterial/genetics; Genes, Bacterial/genetics; Humans; Microbial Sensitivity Tests; Mutation
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Pregledni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Završna verzija rukopisa prihvaćena za objavljivanje (postprint)
• Naslov časopisa: Frontiers in Bioscience
• Brojčani podaci: vol. 23, str. 656-670
• p-ISSN: 1093-4715
• DOI: https://doi.org/10.2741/4611
• URN:NBN: urn:nbn:hr:105:989188
• Datum objave publikacije: 2018-01-01
• URL dokumenta: https://doi.org/10.2741/4611
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2024-03-28 09:09:12