Hypopituitarism after gamma knife radiosurgery for pituitary adenoma

Znanstveni rad - Izvorni znanstveni rad

• Autor: Karin Zibar Tomšić
• Autor: Tina Dušek
• Autor: Ivana Kraljević
• Autor: Zdravko Heinrich
• Autor: Mirsala Solak
• Autor: Ana Vučinović
• Autor: David Ozretić
• Autor: Sergej Mihailović Marasanov
• Autor: Hrvoje Hršak
• Autor: Darko Kaštelan
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti

Sažetak (engleski)

PURPOSE:

The aim of the study was to investigate the incidence of and risk factors for hypopituitarism after gamma knife radiosurgery (GKRS) for pituitary adenoma. -----

MATERIALS AND METHODS:

We conducted a retrospective analysis of the pituitary function of 90 patients who underwent GKRS for pituitary adenoma at the University Hospital Centre Zagreb between 2003 and 2014. Twenty seven of them met the inclusion criteria and the others were excluded from the study due to pituitary insufficiency which was present before GKRS. Eighteen patients had non-functioning and 9 patients had secretory adenomas. Median patients' age was 56 years (24-82). GKRS was performed using the Leksell gamma knife Model C. The median prescription radiation dose was 20 Gy (15-25) and the median tumor volume size was 3.4 cm3 (0.06-16.81). New onset hypopituitarism was defined as a new deficit of one of the three hormonal axes (corticotroph, thyreotroph, or gonadotroph) ≥3 months following GKRS. SPSS was used for statistical analysis, with the significance level at P<0.05. -----

RESULTS:

During the median follow-up period of 72 months (range 6-144), 30% of patients developed new hypopituitarism after GKRS. This corresponds to incidence of one new case of hypopituitarism per 15 patient-years. Age, gender, tumor function, tumor volume, suprasellar extension, prescription dose of radiation, as well as dose-volume to the pituitary gland, stalk and hypothalamus were not predictive factors for the development of hypopituitarism. -----

CONCLUSIONS:

In our cohort of patients with pituitary tumors who underwent GKRS, 30% developed new hypopituitarism during the follow-up period.

• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Završna verzija rukopisa prihvaćena za objavljivanje (postprint)
• Naslov časopisa: Endocrine Research
• Brojčani podaci: vol. 42, br. 4, str. 318-324
• p-ISSN: 0743-5800
• DOI: https://doi.org/10.1080/07435800.2017.1323913
• URN:NBN: urn:nbn:hr:105:695091
• Datum objave publikacije: 2017-11
• URL dokumenta: http://doi.org/10.1080/07435800.2017.1323913
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2024-03-28 09:20:26