prikaz prve stranice dokumenta Modeling of inhomogeneous electromagnetic fields in the nervous system: a novel paradigm in understanding cell interactions, disease etiology and therapy
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Modeling of inhomogeneous electromagnetic fields in the nervous system: a novel paradigm in understanding cell interactions, disease etiology and therapy
Scientific Reports, 8 (2018), 1; 12909. https://doi.org/10.1038/s41598-018-31054-9
Isaković, Jasmina; Dobbs-Dixon, Ian; Chaudhury, Dipesh; Mitrečić, Dinko

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Isaković, J., Dobbs Dixon, I., Chaudhury, D. i Mitrečić, D. (2018). Modeling of inhomogeneous electromagnetic fields in the nervous system: a novel paradigm in understanding cell interactions, disease etiology and therapy. Scientific Reports, 8. (1), 12909. doi: 10.1038/s41598-018-31054-9

Isaković, Jasmina, et al. "Modeling of inhomogeneous electromagnetic fields in the nervous system: a novel paradigm in understanding cell interactions, disease etiology and therapy." Scientific Reports, vol. 8, br. 1, 2018, str. 12909. https://doi.org/10.1038/s41598-018-31054-9

Isaković, Jasmina, Ian Dobbs Dixon, Dipesh Chaudhury i Dinko Mitrečić. "Modeling of inhomogeneous electromagnetic fields in the nervous system: a novel paradigm in understanding cell interactions, disease etiology and therapy." Scientific Reports 8, br. 1 (2018): 12909. https://doi.org/10.1038/s41598-018-31054-9

Isaković, J., et al. (2018) 'Modeling of inhomogeneous electromagnetic fields in the nervous system: a novel paradigm in understanding cell interactions, disease etiology and therapy', Scientific Reports, 8(1), str. 12909. doi: 10.1038/s41598-018-31054-9

Isaković J, Dobbs Dixon I, Chaudhury D, Mitrečić D. Modeling of inhomogeneous electromagnetic fields in the nervous system: a novel paradigm in understanding cell interactions, disease etiology and therapy. Scientific Reports [Internet]. 27.08.2018. [pristupljeno 28.09.2024.];8(1):12909. doi: 10.1038/s41598-018-31054-9

J. Isaković, I. Dobbs Dixon, D. Chaudhury i D. Mitrečić, "Modeling of inhomogeneous electromagnetic fields in the nervous system: a novel paradigm in understanding cell interactions, disease etiology and therapy", Scientific Reports, vol. 8, br. 1, str. 12909, Kolovoz 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:694719. [Citirano: 28.09.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:694719
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Naslov (engleski)Modeling of inhomogeneous electromagnetic fields in the nervous system: a novel paradigm in understanding cell interactions, disease etiology and therapy
AutorJasmina Isaković
AutorIan Dobbs-Dixon
AutorDipesh Chaudhury
AutorDinko Mitrečić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
All major processes in the nervous system depend on interactions between cells and nerve fibers. In this work we present a novel model of inhomogeneous electromagnetic fields originating from nerve fibers and delineate their influence on cells. By expanding Hodgkin-Huxley's applied current into axial current, governed by by [Formula: see text], we reveal that cell-with-neuron interactions are regulated by the strength of the electromagnetic fields, which are homogeneous up to 2.066 μm or 6.606 μm away from neurilemma and axolemma, respectively. At the nodes of Ranvier, these fields reach strengths of 3.0 × 10-12T, while at the myelinated segments they only peak at 2.3 × 10-12T. These are the same fields which are, due to inhomogeneity, detected as 1,000 times weaker by magnetoencephalography. Considering the widespread occurrence of neurodegenerative disorders, our model reveals that a 50% demyelination increases the field strength by 0.35 × 10-12T, while a complete demyelination increases it by 0.7 × 10-12T. Since this suggests that the inhomogeneous electromagnetic fields around neurons play a role in physiological and pathological processes, including cell-to-neuron and cell-to-cell communication, their improved understanding opens up new therapeutic strategies based on electromagnetic field modulation or cell's surface charge alteration.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaScientific Reports
Brojčani podacivol. 8, br. 1, str. 12909
p-ISSN2045-2322
DOIhttps://doi.org/10.1038/s41598-018-31054-9
URN:NBNurn:nbn:hr:105:694719
Datum objave publikacije2018-08-27
URL dokumentahttps://doi.org/10.1038/s41598-018-31054-9
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 09:56:04