prikaz prve stranice dokumenta Association of MAPT haplotype-tagging polymorphisms with cerebrospinal fluid biomarkers of Alzheimer's disease: a preliminary study in a Croatian cohort
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Association of MAPT haplotype-tagging polymorphisms with cerebrospinal fluid biomarkers of Alzheimer's disease: a preliminary study in a Croatian cohort
Brain and Behavior, 8 (2018), 11; e01128. https://doi.org/10.1002/brb3.1128
Babić Leko, Mirjana; Willumsen, Nanet; Nikolac Perković, Matea; Klepac, Nataša; Borovečki, Fran; Hof, Patrick R.; Sonicki, Zdenko; Pivac, Nela; de Silva, Rohan; Šimić, Goran

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Babić Leko, M., Willumsen, N., Nikolac Perković, M., Klepac, N., Borovečki, F., Hof, P. R. ... Šimić, G. (2018). Association of MAPT haplotype-tagging polymorphisms with cerebrospinal fluid biomarkers of Alzheimer's disease: a preliminary study in a Croatian cohort. Brain and Behavior, 8. (11). doi: 10.1002/brb3.1128

Babić Leko, Mirjana, et al. "Association of MAPT haplotype-tagging polymorphisms with cerebrospinal fluid biomarkers of Alzheimer's disease: a preliminary study in a Croatian cohort." Brain and Behavior, vol. 8, br. 11, 2018. https://doi.org/10.1002/brb3.1128

Babić Leko, Mirjana, Nanet Willumsen, Matea Nikolac Perković, Nataša Klepac, Fran Borovečki, Patrick R. Hof, Zdenko Sonicki, Nela Pivac, Rohan de Silva i Goran Šimić. "Association of MAPT haplotype-tagging polymorphisms with cerebrospinal fluid biomarkers of Alzheimer's disease: a preliminary study in a Croatian cohort." Brain and Behavior 8, br. 11 (2018). https://doi.org/10.1002/brb3.1128

Babić Leko, M., et al. (2018) 'Association of MAPT haplotype-tagging polymorphisms with cerebrospinal fluid biomarkers of Alzheimer's disease: a preliminary study in a Croatian cohort', Brain and Behavior, 8(11). doi: 10.1002/brb3.1128

Babić Leko M, Willumsen N, Nikolac Perković M, Klepac N, Borovečki F, Hof PR, i sur.. Association of MAPT haplotype-tagging polymorphisms with cerebrospinal fluid biomarkers of Alzheimer's disease: a preliminary study in a Croatian cohort. Brain and Behavior [Internet]. 11.2018. [pristupljeno 27.10.2024.];8(11). doi: 10.1002/brb3.1128

M. Babić Leko, et al., "Association of MAPT haplotype-tagging polymorphisms with cerebrospinal fluid biomarkers of Alzheimer's disease: a preliminary study in a Croatian cohort", Brain and Behavior, vol. 8, br. 11, Studeni 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:531983. [Citirano: 27.10.2024.]

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Naslov (engleski)Association of MAPT haplotype-tagging polymorphisms with cerebrospinal fluid biomarkers of Alzheimer's disease: a preliminary study in a Croatian cohort
AutorMirjana Babić Leko
AutorNanet Willumsen
AutorMatea Nikolac Perković
AutorNataša Klepac
AutorFran Borovečki
AutorPatrick R. Hof
AutorZdenko Sonicki
AutorNela Pivac
AutorRohan de Silva
AutorGoran Šimić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
INTRODUCTION: Alzheimer's disease (AD) is the world leading cause of dementia. Early detection of AD is essential for faster and more efficacious usage of therapeutics and preventive measures. Even though it is well known that one ε4 allele of apolipoprotein E gene increases the risk for sporadic AD five times, and that two ε4 alleles increase the risk 20 times, reliable genetic markers for AD are not yet available. Previous studies have shown that microtubule-associated protein tau (MAPT) gene polymorphisms could be associated with increased risk for AD. ----- METHODS: The present study included 113 AD patients and 53 patients with mild cognitive impairment (MCI), as well as nine healthy controls (HC) and 53 patients with other primary causes of dementia. The study assessed whether six MAPT haplotype-tagging polymorphisms (rs1467967, rs242557, rs3785883, rs2471738, del-In9, and rs7521) and MAPT haplotypes are associated with AD pathology, as measured by cerebrospinal fluid (CSF) AD biomarkers amyloid β1-42 (Aβ1-42 ), total tau (t-tau), tau phosphorylated at epitopes 181 (p-tau181 ), 199 (p-tau199 ), and 231 (p-tau231 ), and visinin-like protein 1 (VILIP-1). ----- RESULTS: Significant increases in t-tau and p-tau CSF levels were found in patients with AG and AA MAPT rs1467967 genotype, CC MAPT rs2471738 genotype and in patients with H1H2 or H2H2 MAPT haplotype. ----- CONCLUSIONS: These results indicate that MAPT haplotype-tagging polymorphisms and MAPT haplotypes should be further tested as potential genetic biomarkers of AD.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBrain and Behavior
Brojčani podacivol. 8, br. 11, e01128
p-ISSN2162-3279
DOIhttps://doi.org/10.1002/brb3.1128
URN:NBNurn:nbn:hr:105:531983
Datum objave publikacije2018-11
URL dokumentahttps://doi.org/10.1002/brb3.1128
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 09:57:58