prikaz prve stranice dokumenta Platelet serotonin concentration and monoamine oxidase activity in hypothyroid patients
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Platelet serotonin concentration and monoamine oxidase activity in hypothyroid patients
Hormone Research, 71 (2009), 4; 207-212. https://doi.org/10.1159/000201109
Stipčević, Tamara; Kusačić-Kuna, Sanja; Deželjin, Martina; Dodig, Damir; Koršić, Mirko; Pivac, Nela; Mück-Šeler, Dorotea

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Stipčević, T., Kusačić Kuna, S., Deželjin, M., Dodig, D., Koršić, M., Pivac, N. i Mück Šeler, D. (2009). Platelet serotonin concentration and monoamine oxidase activity in hypothyroid patients. Hormone Research, 71. (4), 207-212. doi: 10.1159/000201109

Stipčević, Tamara, et al. "Platelet serotonin concentration and monoamine oxidase activity in hypothyroid patients." Hormone Research, vol. 71, br. 4, 2009, str. 207-212. https://doi.org/10.1159/000201109

Stipčević, Tamara, Sanja Kusačić Kuna, Martina Deželjin, Damir Dodig, Mirko Koršić, Nela Pivac i Dorotea Mück Šeler. "Platelet serotonin concentration and monoamine oxidase activity in hypothyroid patients." Hormone Research 71, br. 4 (2009): 207-212. https://doi.org/10.1159/000201109

Stipčević, T., et al. (2009) 'Platelet serotonin concentration and monoamine oxidase activity in hypothyroid patients', Hormone Research, 71(4), str. 207-212. doi: 10.1159/000201109

Stipčević T, Kusačić Kuna S, Deželjin M, Dodig D, Koršić M, Pivac N, i sur.. Platelet serotonin concentration and monoamine oxidase activity in hypothyroid patients. Hormone Research [Internet]. 04.03.2009. [pristupljeno 28.11.2024.];71(4):207-212. doi: 10.1159/000201109

T. Stipčević, et al., "Platelet serotonin concentration and monoamine oxidase activity in hypothyroid patients", Hormone Research, vol. 71, br. 4, str. 207-212, Ožujak 2009. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:598279. [Citirano: 28.11.2024.]

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Podaci o radu
Naslov (engleski)Platelet serotonin concentration and monoamine oxidase activity in hypothyroid patients
AutorTamara Stipčević
AutorSanja Kusačić-Kuna
AutorMartina Deželjin
AutorDamir Dodig
AutorMirko Koršić
AutorNela Pivac
AutorDorotea Mück-Šeler
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND/AIM: The relationship between the hypothalamic-pituitary-thyroid (HPT) axis and the serotonergic (5-hydroxytryptamine, 5-HT) system is not clear. The aim of the study was to determine platelet biochemical markers (5-HT concentration and monoamine oxidase B, MAO-B, activity) in hypothyroid patients. ----- METHODS: The study included 25 medication-free female hypothyroid patients in postoperative follow-up after total thyroidectomy due to papillary thyroid carcinoma, who had not been treated with synthetic thyroxine (T(4)) for 4 weeks, and 44 age-matched euthyroid healthy women. The platelet 5-HT concentration, platelet MAO-B activity, total T(4) and thyroid-stimulating hormone (TSH) levels were determined using spectrofluorimetric methods, radioimmunoassay and fluoroimmunoassay, respectively. ----- RESULTS: Hypothyroid patients had significantly higher TSH, significantly lower T(4) levels and platelet 5-HT concentrations, and unchanged platelet MAO-B activity than healthy subjects. A positive correlation was found between the 5-HT concentration and platelet MAO-B activity, and between the platelet MAO-B activity and T(4) in control subjects. ----- CONCLUSIONS: Reduced platelet 5-HT concentrations in hypothyroid patients suggests a complex interaction between the 5-HT system and HPT axis activity, which could be related to the frequent occurrence of depressive symptoms in hypothyroid patients. The determination of platelet 5-HT concentrations should be considered a diagnostic tool for the evaluation of depressive symptoms in hypothyroid patients during the hormone withdrawal procedure.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaHormone Research
Brojčani podacivol. 71, br. 4, str. 207-212
p-ISSN0301-0163
DOIhttps://doi.org/10.1159/000201109
URN:NBNurn:nbn:hr:105:598279
Datum objave publikacije2009-03-04
URL dokumentahttps://doi.org/10.1159/000201109
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 11:13:44