Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach

Znanstveni rad - Izvorni znanstveni rad

• Autor: Melita Šalković-Petrišić
• Autor: Siegfried Hoyer
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti

Sažetak (engleski)

A growing body of evidence implicates impairments in brain insulin signaling in early sporadic Alzheimer disease (sAD) pathology. However, the most widely accepted hypothesis for AD aetiology stipulates that pathological aggregations of the amyloid beta (Abeta) peptide are the cause of all forms of Alzheimer's disease. Streptozotocin-intracerebroventricularly (STZ-icv) treated rats are proposed as a probable experimental model of sAD. The current work reviews evidence obtained from this model indicating that central STZ administration induces brain pathology and behavioural alterations resembling those in sAD patients. Recently, alterations of the brain insulin system resembling those in sAD have been found in the STZ-icv rat model and are associated with tau protein hyperphosphorylation and Abeta-like aggregations in meningeal vessels. In line with these findings the hypothesis has been proposed that insulin resistance in the brain might be the primary event which precedes the Abeta pathology in sAD.

• Ključne riječi (engleski): Alzheimer Disease/chemically induced; Alzheimer Disease/pathology; Alzheimer Disease/physiopathology; Amyloid beta-Protein/metabolism; Amyloid beta-Protein Precursor/metabolism; Animals; Blood Glucose/metabolism; Brain/drug effects; Brain/pathology; Brain/physiopathology; Disease Models, Animal; Glucose Transporter Type 4/drug effects; Glucose Transporter Type 4/physiology; Humans; Injections, Intraventricular; Insulin/physiology; Insulin Resistance/physiology; Learning/drug effects; Learning/physiology; Memory/drug effects; Memory/physiology; Neurotoxins/pharmacology; Rats; Receptor, Insulin/drug effects; Receptor, Insulin/physiology; Receptors, Cell Surface/metabolism; Signal Transduction/drug effects; Signal Transduction/physiology; Streptozocin/pharmacology; tau Proteins/metabolism
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Završna verzija rukopisa prihvaćena za objavljivanje (postprint)
• Naslov časopisa: Journal of Neural Transmission. Supplementum
• Brojčani podaci: vol. 72, str. 217-33
• p-ISSN: 0303-6975
• DOI: https://doi.org/10.1007/978-3-211-73574-9_28
• URN:NBN: urn:nbn:hr:105:989050
• Datum objave publikacije: 2007-12-28
• URL dokumenta: https://doi.org/10.1007/978-3-211-73574-9_28
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2024-03-28 11:35:23